Entity Details

Primary name GATA3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP23771
EntryNameGATA3_HUMAN
FullNameTrans-acting T-cell-specific transcription factor GATA-3
TaxID9606
Evidenceevidence at protein level
Length443
SequenceStatuscomplete
DateCreated1991-11-01
DateModified2021-06-02

Ontological Relatives

GenesGATA3

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001701 in utero embryonic development
GO:0001709 cell fate determination
GO:0001764 neuron migration
GO:0001806 type IV hypersensitivity
GO:0001817 regulation of cytokine production
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0002088 lens development in camera-type eye
GO:0002520 immune system development
GO:0002572 pro-T cell differentiation
GO:0003180 aortic valve morphogenesis
GO:0003215 cardiac right ventricle morphogenesis
GO:0003281 ventricular septum development
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005134 interleukin-2 receptor binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006338 chromatin remodeling
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006952 defense response
GO:0006959 humoral immune response
GO:0007165 signal transduction
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0008285 negative regulation of cell population proliferation
GO:0008584 male gonad development
GO:0009615 response to virus
GO:0009653 anatomical structure morphogenesis
GO:0009791 post-embryonic development
GO:0009967 positive regulation of signal transduction
GO:0010332 response to gamma radiation
GO:0010595 positive regulation of endothelial cell migration
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0010975 regulation of neuron projection development
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0016579 protein deubiquitination
GO:0019221 cytokine-mediated signaling pathway
GO:0030217 T cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030856 regulation of epithelial cell differentiation
GO:0031929 TOR signaling
GO:0032689 negative regulation of interferon-gamma production
GO:0032703 negative regulation of interleukin-2 production
GO:0032736 positive regulation of interleukin-13 production
GO:0032753 positive regulation of interleukin-4 production
GO:0032754 positive regulation of interleukin-5 production
GO:0033600 negative regulation of mammary gland epithelial cell proliferation
GO:0035162 embryonic hemopoiesis
GO:0035457 cellular response to interferon-alpha
GO:0035799 ureter maturation
GO:0035898 parathyroid hormone secretion
GO:0042421 norepinephrine biosynthetic process
GO:0042472 inner ear morphogenesis
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation
GO:0043523 regulation of neuron apoptotic process
GO:0043583 ear development
GO:0043627 response to estrogen
GO:0045061 thymic T cell selection
GO:0045064 T-helper 2 cell differentiation
GO:0045087 innate immune response
GO:0045165 cell fate commitment
GO:0045471 response to ethanol
GO:0045582 positive regulation of T cell differentiation
GO:0045599 negative regulation of fat cell differentiation
GO:0045786 negative regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048469 cell maturation
GO:0048485 sympathetic nervous system development
GO:0048538 thymus development
GO:0048568 embryonic organ development
GO:0048589 developmental growth
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0050728 negative regulation of inflammatory response
GO:0050852 T cell receptor signaling pathway
GO:0051569 regulation of histone H3-K4 methylation
GO:0051897 positive regulation of protein kinase B signaling
GO:0060017 parathyroid gland development
GO:0060037 pharyngeal system development
GO:0060065 uterus development
GO:0060231 mesenchymal to epithelial transition
GO:0060374 mast cell differentiation
GO:0060676 ureteric bud formation
GO:0061085 regulation of histone H3-K27 methylation
GO:0061290 canonical Wnt signaling pathway involved in metanephric kidney development
GO:0070888 E-box binding
GO:0071353 cellular response to interleukin-4
GO:0071356 cellular response to tumor necrosis factor
GO:0071442 positive regulation of histone H3-K14 acetylation
GO:0071599 otic vesicle development
GO:0071773 cellular response to BMP stimulus
GO:0071837 HMG box domain binding
GO:0072107 positive regulation of ureteric bud formation
GO:0072178 nephric duct morphogenesis
GO:0072179 nephric duct formation
GO:0072182 regulation of nephron tubule epithelial cell differentiation
GO:0072197 ureter morphogenesis
GO:0072676 lymphocyte migration
GO:0090102 cochlea development
GO:1901536 negative regulation of DNA demethylation
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000114 regulation of establishment of cell polarity
GO:2000146 negative regulation of cell motility
GO:2000352 negative regulation of endothelial cell apoptotic process
GO:2000553 positive regulation of T-helper 2 cell cytokine production
GO:2000607 negative regulation of cell proliferation involved in mesonephros development
GO:2000611 positive regulation of thyroid hormone generation
GO:2000617 positive regulation of histone H3-K9 acetylation
GO:2000679 positive regulation of transcription regulatory region DNA binding
GO:2000683 regulation of cellular response to X-ray
GO:2000703 negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation
GO:2000734 negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation

Subcellular Location

Show/Hide Table
Subcellular Location
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000679 Zinc finger, GATA-typeDomainDomain
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR016374 Transcription factor, GATA-2/3FamilyFamily
IPR029521 Transcription factor GATA-3FamilyFamily
IPR039355 Transcription factor GATAFamilyFamily

Diseases

Show/Hide Table

Interactions

48 interactions

InteractorPartnerSourcesPublicationsLink
GATA3_HUMANPSA3_HUMANBioGRID, IntAct25416956 details
GATA3_HUMANHDAC2_HUMANBioGRID, IntAct26028330 29453984 31409898 details
GATA3_HUMANHDAC1_HUMANBioGRID, IntAct26028330 29453984 31409898 details
GATA3_HUMANMTA3_HUMANIntAct26028330 details
GATA3_HUMANEHMT2_HUMANIntAct26028330 details
GATA3_HUMANKDM1A_HUMANBioGRID, IntAct26028330 31409898 details
GATA3_HUMANLCK_HUMANBioGRID, IntAct26871637 details
GATA3_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
GATA3_HUMANKR132_HUMANBioGRID, IntAct32296183 details
GATA3_HUMANPKHG4_HUMANBioGRID, IntAct32296183 details
GATA3_HUMANKRA62_HUMANBioGRID, IntAct32296183 details
GATA3_HUMANKR121_HUMANBioGRID, IntAct32296183 details
GATA3_HUMANACTN2_HUMANBioGRID, IntAct25910212 details
GATA3_HUMANHDAC3_HUMANBioGRID, DIP17075044 29453984 details
GATA3_HUMANTRI55_HUMANBioGRID, IntAct31391242 details
GATA3_HUMANHIF1A_HUMANBioGRID, MINT28263977 details
GATA3_HUMANCLAT_HUMANIntAct32814053 details
GATA3_HUMANFGFR3_HUMANIntAct32814053 details
GATA3_HUMANRARB_HUMANBioGRID, IntAct20211142 details
GATA3_HUMANRBTN1_HUMANBioGRID, HPRD9020185 9819382 details
GATA3_HUMANSP1_HUMANBioGRID18338249 details
GATA3_HUMANREPI1_HUMANBioGRID18338249 details
GATA3_HUMANSPI1_HUMANBioGRID10364157 details
GATA3_HUMANCDK2_HUMANBioGRID24820417 details
GATA3_HUMANFBXW7_HUMANBioGRID24820417 details
GATA3_HUMANMK14_HUMANBioGRID24820417 details
GATA3_HUMANCBP_HUMANBioGRID29453984 details
GATA3_HUMANTRI63_HUMANBioGRID31391242 details
GATA3_HUMANFOG2_HUMANHPRD14985365 details
GATA3_HUMANTAL1_HUMANBioGRID, HPRD, MINT21179004 9819382 details
GATA3_HUMANSOX4_HUMANInnateDB22751141 details
GATA3_HUMANMDM2_HUMANBioGRID, IntAct15975924 26028330 details
GATA3_HUMANHDAC5_HUMANBioGRID, DIP17075044 details
GATA3_HUMANTBX21_HUMANBioGRID, DIP17075044 details
GATA3_HUMANGCM1_HUMANIntAct26899996 details
GATA3_HUMANRBTN2_HUMANBioGRID, HPRD9819382 details
GATA3_HUMANBMI1_HUMANBioGRID17114435 details
GATA3_HUMANHDAC4_HUMANBioGRID16922677 details
GATA3_HUMANMYB_HUMANBioGRID22039304 details
GATA3_HUMANBRCA1_HUMANBioGRID22120723 details
GATA3_HUMANUBP21_HUMANBioGRID23395819 details
GATA3_HUMANFOXP3_HUMANBioGRID23395819 details
GATA3_HUMANTF7L2_HUMANBioGRID22951069 details
GATA3_HUMANRCOR1_HUMANBioGRID31409898 details
GATA3_HUMANSATB1_HUMANHPRD17057718 details
GATA3_HUMANETS1_HUMANHPRD10212281 details
GATA3_HUMANETS2_HUMANHPRD10212281 details
GATA3_HUMANMED1_HUMANHPRD11724781 details