Entity Details

Primary name EDNRB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP24530
EntryNameEDNRB_HUMAN
FullNameEndothelin receptor type B
TaxID9606
Evidenceevidence at protein level
Length442
SequenceStatuscomplete
DateCreated1992-03-01
DateModified2021-06-02

Ontological Relatives

GenesEDNRB

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001755 neural crest cell migration
GO:0001934 positive regulation of protein phosphorylation
GO:0004962 endothelin receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006885 regulation of pH
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007399 nervous system development
GO:0007422 peripheral nervous system development
GO:0007497 posterior midgut development
GO:0007568 aging
GO:0008217 regulation of blood pressure
GO:0008284 positive regulation of cell population proliferation
GO:0014043 negative regulation of neuron maturation
GO:0014070 response to organic cyclic compound
GO:0014826 vein smooth muscle contraction
GO:0017046 peptide hormone binding
GO:0019233 sensory perception of pain
GO:0019722 calcium-mediated signaling
GO:0019934 cGMP-mediated signaling
GO:0030318 melanocyte differentiation
GO:0031620 regulation of fever generation
GO:0031702 type 1 angiotensin receptor binding
GO:0031965 nuclear membrane
GO:0032269 negative regulation of cellular protein metabolic process
GO:0035645 enteric smooth muscle cell differentiation
GO:0035810 positive regulation of urine volume
GO:0035815 positive regulation of renal sodium excretion
GO:0042045 epithelial fluid transport
GO:0042310 vasoconstriction
GO:0042311 vasodilation
GO:0043066 negative regulation of apoptotic process
GO:0045121 membrane raft
GO:0048246 macrophage chemotaxis
GO:0048265 response to pain
GO:0048484 enteric nervous system development
GO:0050678 regulation of epithelial cell proliferation
GO:0051930 regulation of sensory perception of pain
GO:0060406 positive regulation of penile erection
GO:0071222 cellular response to lipopolysaccharide
GO:0086100 endothelin receptor signaling pathway
GO:1990839 response to endothelin

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000499 Endothelin receptor familyFamilyFamily
IPR001112 Endothelin receptor BFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00559 BosentanDrugbanksmall molecule
DB06138 IRL-1620Drugbanksmall molecule
DB06268 SitaxentanDrugbanksmall molecule
DB06403 AmbrisentanDrugbanksmall molecule
DB06460 EnrasentanDrugbanksmall molecule
DB06558 TezosentanDrugbanksmall molecule
DB08932 MacitentanDrugbanksmall molecule