Entity Details

Primary name DNAS1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP24855
EntryNameDNAS1_HUMAN
FullNameDeoxyribonuclease-1
TaxID9606
Evidenceevidence at protein level
Length282
SequenceStatuscomplete
DateCreated1992-03-01
DateModified2021-06-02

Ontological Relatives

GenesDNASE1

GO terms

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GOName
GO:0000737 DNA catabolic process, endonucleolytic
GO:0002283 neutrophil activation involved in immune response
GO:0002673 regulation of acute inflammatory response
GO:0003677 DNA binding
GO:0003779 actin binding
GO:0004530 deoxyribonuclease I activity
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0006308 DNA catabolic process
GO:0006915 apoptotic process
GO:0070062 extracellular exosome
GO:0070948 regulation of neutrophil mediated cytotoxicity

Subcellular Location

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Subcellular Location
Nucleus envelope
Secreted
Zymogen granule

Domains

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DomainNameCategoryType
IPR005135 Endonuclease/exonuclease/phosphataseDomainDomain
IPR016202 Deoxyribonuclease IFamilyFamily
IPR018057 Deoxyribonuclease I, active siteSiteActive site
IPR033125 Deoxyribonuclease I, conservied siteSiteConserved site
IPR036691 Endonuclease/exonuclease/phosphatase superfamilyFamilyHomologous superfamily

Diseases

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Interactions

4 interactions