Entity Details

Primary name RFA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP27694
EntryNameRFA1_HUMAN
FullNameReplication protein A 70 kDa DNA-binding subunit
TaxID9606
Evidenceevidence at protein level
Length616
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesRPA1

GO terms

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GOName
GO:0000723 telomere maintenance
GO:0000724 double-strand break repair via homologous recombination
GO:0000781 chromosome, telomeric region
GO:0003684 damaged DNA binding
GO:0003697 single-stranded DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005662 DNA replication factor A complex
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006284 base-excision repair
GO:0006287 base-excision repair, gap-filling
GO:0006289 nucleotide-excision repair
GO:0006293 nucleotide-excision repair, preincision complex stabilization
GO:0006294 nucleotide-excision repair, preincision complex assembly
GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006297 nucleotide-excision repair, DNA gap filling
GO:0006298 mismatch repair
GO:0006310 DNA recombination
GO:0006974 cellular response to DNA damage stimulus
GO:0007004 telomere maintenance via telomerase
GO:0016605 PML body
GO:0019985 translesion synthesis
GO:0032201 telomere maintenance via semi-conservative replication
GO:0033683 nucleotide-excision repair, DNA incision
GO:0034502 protein localization to chromosome
GO:0036297 interstrand cross-link repair
GO:0042276 error-prone translesion synthesis
GO:0042769 DNA damage response, detection of DNA damage
GO:0043047 single-stranded telomeric DNA binding
GO:0046872 metal ion binding
GO:0051321 meiotic cell cycle
GO:0070987 error-free translesion synthesis
GO:0090734 site of DNA damage
GO:0098505 G-rich strand telomeric DNA binding
GO:1900034 regulation of cellular response to heat
GO:1901796 regulation of signal transduction by p53 class mediator

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-typeDomainDomain
IPR004591 Replication factor A protein 1FamilyFamily
IPR007199 Replication factor-A protein 1, N-terminalDomainDomain
IPR012340 Nucleic acid-binding, OB-foldFamilyHomologous superfamily
IPR013955 Replication factor A, C-terminalDomainDomain
IPR031657 Replication protein A, OB domainDomainDomain

Diseases

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Interactions

129 interactions

InteractorPartnerSourcesPublicationsLink
RFA1_HUMANRFA2_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt10064605 11927569 12527904 12754299 15965237 20679368 20811460 21504906 2159011 22863883 22939629 24126761 24981860 25499885 26186194 26344197 26474068 26496610 27723720 28514442 28575657 30279242 32296183 7760808 8663296 9461578 details
RFA1_HUMANRFA3_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt11927569 12527904 19338310 20811460 21504906 2159011 22939629 24126761 24981860 26344197 26474068 26496610 27723720 7760808 9461578 details
RFA1_HUMANPRI2_HUMANMINT17673209 details
RFA1_HUMANRFWD3_HUMANBioGRID, MINT21504906 21558276 24126761 24332808 26474068 28575657 28575658 28666352 29576527 30530694 details
RFA1_HUMANORC6_HUMANBioGRID12614612 details
RFA1_HUMANHGH1_HUMANBioGRID, HPRD16169070 details
RFA1_HUMANMUTYH_HUMANBioGRID, HPRD11092888 details
RFA1_HUMANFANCJ_HUMANBioGRID17596542 20159562 details
RFA1_HUMANBID_HUMANBioGRID21859891 details
RFA1_HUMANPRP19_HUMANBioGRID24332808 26474068 28666352 details
RFA1_HUMANP53_HUMANBioGRID, HPRD, IntAct11751427 15489903 15735006 23267009 32807901 8361542 8663296 9121469 details
RFA1_HUMANRAD51_HUMANBioGRID, HPRD, IntAct12077133 19338310 9826763 details
RFA1_HUMANPRIPO_HUMANBioGRID, MINT24126761 details
RFA1_HUMANWRN_HUMANBioGRID, HPRD, IntAct, MINT10373438 15735006 15965237 24126761 24332808 26474068 27723720 30279242 details
RFA1_HUMANBLM_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10825162 11950880 12181313 12724401 15775963 15965237 24126761 24239288 24332808 25135477 26474068 30279242 details
RFA1_HUMANHAX1_HUMANBioGRID, IntAct21988832 details
RFA1_HUMANMTUS2_HUMANBioGRID, IntAct25416956 32296183 details
RFA1_HUMANATR_HUMANBioGRID10608806 18162465 24332808 details
RFA1_HUMANRAD9A_HUMANBioGRID, HPRD15897895 18936170 details
RFA1_HUMANHNRL1_HUMANBioGRID18480432 24332808 details
RFA1_HUMANCCNA1_HUMANBioGRID8397206 details
RFA1_HUMANEHMT2_HUMANBioGRID28698370 details
RFA1_HUMANTCEA2_HUMANBioGRID, HPRD, IntAct16169070 details
RFA1_HUMANXPA_HUMANBioGRID, DIP, HPRD, IntAct12527904 19446504 20304803 7565690 details
RFA1_HUMANSMAD3_HUMANBioGRID, IntAct21988832 details
RFA1_HUMANATRIP_HUMANBioGRID, HPRD12791985 18936170 21859891 22258451 23723247 24332808 25916848 31757956 details
RFA1_HUMANXPC_HUMANBioGRID15914671 24981860 details
RFA1_HUMANCBPE_HUMANBioGRID, HPRD, IntAct16169070 details
RFA1_HUMANKS6A5_HUMANBioGRID, IntAct21988832 details
RFA1_HUMANANXA1_HUMANBioGRID, MINT21900206 details
RFA1_HUMANRFA4_HUMANBioGRID, HPRD, IntAct, UniProt25499885 26186194 28514442 7760808 details
RFA1_HUMANPAXI1_HUMANBioGRID22990118 details
RFA1_HUMANCDC5L_HUMANBioGRID20467437 24332808 details
RFA1_HUMANCSK2B_HUMANBioGRID, MINT21900206 details
RFA1_HUMANRAD52_HUMANBioGRID, HPRD, MINT12077133 12139939 24126761 28551686 details
RFA1_HUMANCCNB1_HUMANBioGRID8397206 details
RFA1_HUMANAKTIP_HUMANBioGRID, HPRD, IntAct16169070 details
RFA1_HUMANGNB5_HUMANBioGRID, IntAct21988832 details
RFA1_HUMANPRKDC_HUMANBioGRID, HPRD10064605 21504906 24332808 details
RFA1_HUMANANXA7_HUMANBioGRID, MINT21900206 details
RFA1_HUMANCDK1_HUMANBioGRID20679368 8397206 8397207 details
RFA1_HUMANASCC2_HUMANBioGRID, HPRD, IntAct16169070 details
RFA1_HUMANKITH_HUMANBioGRID, MINT21900206 details
RFA1_HUMANMCM7_HUMANBioGRID, HPRD12614612 details
RFA1_HUMANSBP1_HUMANBioGRID, HPRD, IntAct16169070 details
RFA1_HUMANRCC1_HUMANBioGRID, MINT21900206 details
RFA1_HUMANHSP76_HUMANBioGRID, IntAct32296183 details
RFA1_HUMANMCM2_HUMANBioGRID, HPRD12614612 25963833 details
RFA1_HUMANMCM4_HUMANBioGRID12614612 details
RFA1_HUMANCCNA2_HUMANBioGRID8798463 details
RFA1_HUMANMMS22_HUMANBioGRID27797818 details
RFA1_HUMANMCM6_HUMANBioGRID12614612 details
RFA1_HUMANCDK2_HUMANBioGRID20679368 8397206 details
RFA1_HUMANRBM23_HUMANBioGRID, HPRD16169070 details
RFA1_HUMANXPF_HUMANBioGRID21875596 9013642 details
RFA1_HUMANZBT14_HUMANBioGRID31757956 details
RFA1_HUMANBRCA2_HUMANBioGRID, HPRD, IntAct12527904 details
RFA1_HUMANEXO5_HUMANBioGRID23095756 details
RFA1_HUMANSEM1_HUMANBioGRID26145171 details
RFA1_HUMANACTB_HUMANBioGRID, IntAct19338310 24332808 details
RFA1_HUMANVIME_HUMANBioGRID, IntAct21988832 details
RFA1_HUMANORC2_HUMANBioGRID, HPRD12614612 details
RFA1_HUMANRD23B_HUMANBioGRID15914671 details
RFA1_HUMANATM_HUMANBioGRID10713094 details
RFA1_HUMANERCC1_HUMANBioGRID24036546 details
RFA1_HUMANSEML_HUMANBioGRID26145171 details
RFA1_HUMANTIPIN_HUMANBioGRID, MINT17296725 20679368 24126761 details
RFA1_HUMANHERC2_HUMANBioGRID22261722 26474068 30279242 31582797 details
RFA1_HUMANHLTF_HUMANBioGRID24332808 24981860 26474068 27723720 details
RFA1_HUMANBRCA1_HUMANBioGRID, DIP, MINT, UniProt19369211 19766185 21240188 23901102 29656893 details
RFA1_HUMANSMAL1_HUMANBioGRID, MINT21504906 24126761 24332808 24981860 26474068 27723720 29576527 details
RFA1_HUMANPCNA_HUMANBioGRID, HPRD11254741 12171929 15831485 20227374 21504906 24958773 details
RFA1_HUMANPRI1_HUMANBioGRID17035231 details
RFA1_HUMANSH3K1_HUMANBioGRID19531213 details
RFA1_HUMANRFC4_HUMANBioGRID24332808 26474068 details
RFA1_HUMANRFA1_HUMANBioGRID, HPRD11927569 24126761 details
RFA1_HUMANFANCM_HUMANBioGRID20347428 details
RFA1_HUMANDNLI3_HUMANBioGRID24332808 26474068 details
RFA1_HUMANRFC2_HUMANBioGRID24332808 24981860 26474068 details
RFA1_HUMANSLX4_HUMANBioGRID25533185 details
RFA1_HUMANMO4L1_HUMANBioGRID21466675 details
RFA1_HUMANDPOLL_HUMANBioGRID, HPRD, IntAct17507928 27173435 unassigned1312 details
RFA1_HUMANTF2H1_HUMANBioGRID11259578 details
RFA1_HUMANFBH1_HUMANBioGRID23319600 24332808 details
RFA1_HUMANXRCC1_HUMANBioGRID24332808 26474068 details
RFA1_HUMANMRE11_HUMANBioGRID18936170 24332808 30179224 details
RFA1_HUMANTOP3A_HUMANBioGRID, MINT12724401 24126761 24332808 details
RFA1_HUMANHELB_HUMANBioGRID, HPRD, MINT12181327 24126761 27723720 details
RFA1_HUMANKIN17_HUMANBioGRID12754299 15831485 details
RFA1_HUMANHUS1_HUMANBioGRID, HPRD15897895 details
RFA1_HUMANRPB1_HUMANBioGRID16916636 details
RFA1_HUMANPARP1_HUMANBioGRID24332808 27723720 details
RFA1_HUMANSETD2_HUMANBioGRID24931610 details
RFA1_HUMANDTX2_HUMANBioGRID32937373 details
RFA1_HUMANRAD1_HUMANBioGRID15897895 details
RFA1_HUMANRNF4_HUMANBioGRID22661229 details
RFA1_HUMANERPG3_HUMANBioGRID16916636 details
RFA1_HUMANCTF18_HUMANBioGRID24332808 27723720 details
RFA1_HUMANDERL1_HUMANBioGRID28137758 details
RFA1_HUMANCLSPN_HUMANBioGRID, MINT20679368 24126761 details
RFA1_HUMANTOPB1_HUMANBioGRID20159562 details
RFA1_HUMANMCMBP_HUMANBioGRID20679368 details
RFA1_HUMANRFC1_HUMANBioGRID24332808 26474068 details
RFA1_HUMANPOLK_HUMANBioGRID20227374 details
RFA1_HUMANDMC1_HUMANHPRD9826763 details
RFA1_HUMANDPOLA_HUMANBioGRID, MINT17666013 24332808 details
RFA1_HUMANMSH4_HUMANBioGRID, HPRD11950880 details
RFA1_HUMANRFC5_HUMANBioGRID, MINT24332808 24981860 26474068 details
RFA1_HUMANSPRTN_HUMANBioGRID22894931 details
RFA1_HUMANFANCG_HUMANBioGRID12724401 details
RFA1_HUMANFANCA_HUMANBioGRID12724401 12973351 22705371 details
RFA1_HUMANAICDA_HUMANBioGRID, HPRD16251902 23277564 details
RFA1_HUMANPSMD4_HUMANBioGRID22661229 details
RFA1_HUMANZUP1_HUMANBioGRID29476094 29563501 29576527 29576528 details
RFA1_HUMANPSF1_HUMANBioGRID20679368 details
RFA1_HUMANMCM5_HUMANBioGRID20679368 details
RFA1_HUMANERCC6_HUMANBioGRID16916636 details
RFA1_HUMANCENPX_HUMANBioGRID20347428 details
RFA1_HUMANCHD1L_HUMANBioGRID19661379 details
RFA1_HUMANCENPS_HUMANBioGRID20347428 details
RFA1_HUMANCDK4_HUMANBioGRID20679368 details
RFA1_HUMANTP53B_HUMANBioGRID, UniProt15856006 29656893 details
RFA1_HUMANCAF1A_HUMANBioGRID19059499 details
RFA1_HUMANFACD2_HUMANBioGRID24794430 details
RFA1_HUMANSPTA1_HUMANBioGRID16889989 details
RFA1_HUMANMCPH1_HUMANBioGRID16872911 details
RFA1_HUMANRAD17_HUMANBioGRID20679368 details
RFA1_HUMANRECQ1_HUMANHPRD15096578 details
RFA1_HUMANETAA1_HUMANBioGRID27723720 details