Entity Details

Primary name CPSM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP31327
EntryNameCPSM_HUMAN
FullNameCarbamoyl-phosphate synthase [ammonia], mitochondrial
TaxID9606
Evidenceevidence at protein level
Length1500
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesCPS1

GO terms

Show/Hide Table
GOName
GO:0000050 urea cycle
GO:0004087 carbamoyl-phosphate synthase (ammonia) activity
GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GO:0004175 endopeptidase activity
GO:0005509 calcium ion binding
GO:0005524 ATP binding
GO:0005543 phospholipid binding
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006541 glutamine metabolic process
GO:0006807 nitrogen compound metabolic process
GO:0007494 midgut development
GO:0009636 response to toxic substance
GO:0010043 response to zinc ion
GO:0014075 response to amine
GO:0016595 glutamate binding
GO:0019240 citrulline biosynthetic process
GO:0019433 triglyceride catabolic process
GO:0032094 response to food
GO:0032496 response to lipopolysaccharide
GO:0032991 protein-containing complex
GO:0042311 vasodilation
GO:0042493 response to drug
GO:0042594 response to starvation
GO:0042645 mitochondrial nucleoid
GO:0043200 response to amino acid
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0044877 protein-containing complex binding
GO:0046209 nitric oxide metabolic process
GO:0050667 homocysteine metabolic process
GO:0055081 anion homeostasis
GO:0060416 response to growth hormone
GO:0070365 hepatocyte differentiation
GO:0070409 carbamoyl phosphate biosynthetic process
GO:0071242 cellular response to ammonium ion
GO:0071320 cellular response to cAMP
GO:0071377 cellular response to glucagon stimulus
GO:0071400 cellular response to oleic acid
GO:0071548 response to dexamethasone
GO:0072341 modified amino acid binding

Subcellular Location

Show/Hide Table
Subcellular Location
Mitochondrion
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR002474 Carbamoyl-phosphate synthase small subunit, N-terminal domainDomainDomain
IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domainDomainDomain
IPR005480 Carbamoyl-phosphate synthetase, large subunit oligomerisation domainDomainDomain
IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domainDomainDomain
IPR006274 Carbamoyl-phosphate synthase, small subunitFamilyFamily
IPR006275 Carbamoyl-phosphate synthase, large subunitFamilyFamily
IPR011607 Methylglyoxal synthase-like domainDomainDomain
IPR011761 ATP-grasp foldDomainDomain
IPR013815 ATP-grasp fold, subdomain 1FamilyHomologous superfamily
IPR016185 Pre-ATP-grasp domain superfamilyFamilyHomologous superfamily
IPR017926 Glutamine amidotransferaseDomainDomain
IPR029062 Class I glutamine amidotransferase-likeFamilyHomologous superfamily
IPR035686 Carbamoyl-phosphate synthase small subunit, GATase1 domainDomainDomain
IPR036480 Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamilyFamilyHomologous superfamily
IPR036897 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamilyFamilyHomologous superfamily
IPR036914 Methylglyoxal synthase-like domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB06775 Carglumic acidDrugbanksmall molecule
DB11118 AmmoniaSwissprotsmall molecule