Entity Details

Primary name CGL_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP32929
EntryNameCGL_HUMAN
FullNameCystathionine gamma-lyase
TaxID9606
Evidenceevidence at protein level
Length405
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesCTH

GO terms

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GOName
GO:0000098 sulfur amino acid catabolic process
GO:0004123 cystathionine gamma-lyase activity
GO:0005516 calmodulin binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006534 cysteine metabolic process
GO:0016846 carbon-sulfur lyase activity
GO:0018272 protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
GO:0019343 cysteine biosynthetic process via cystathionine
GO:0019344 cysteine biosynthetic process
GO:0019346 transsulfuration
GO:0030170 pyridoxal phosphate binding
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0042802 identical protein binding
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044524 protein sulfhydration
GO:0044540 L-cystine L-cysteine-lyase (deaminating)
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051289 protein homotetramerization
GO:0070062 extracellular exosome
GO:0070814 hydrogen sulfide biosynthetic process
GO:0080146 L-cysteine desulfhydrase activity
GO:1904831 positive regulation of aortic smooth muscle cell differentiation
GO:1990830 cellular response to leukemia inhibitory factor
GO:2001234 negative regulation of apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzymeFamilyFamily
IPR015421 Pyridoxal phosphate-dependent transferase, major domainFamilyHomologous superfamily
IPR015422 Pyridoxal phosphate-dependent transferase, small domainFamilyHomologous superfamily
IPR015424 Pyridoxal phosphate-dependent transferaseFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00114 Pyridoxal phosphateDrugbanksmall molecule
DB00151 CysteineDrugbanksmall molecule
DB02328 2-[(3-Hydroxy-2-Methyl-5-Phosphonooxymethyl-Pyridin-4-Ylmethyl)-Imino]-5-Phosphono-Pent-3-Enoic AcidDrugbanksmall molecule
DB03928 Carboxymethylthio-3-(3-Chlorophenyl)-1,2,4-OxadiazolDrugbanksmall molecule
DB04217 L-2-amino-3-butynoic acidDrugbanksmall molecule

Interactions

6 interactions