Entity Details

Primary name C2TA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP33076
EntryNameC2TA_HUMAN
FullNameMHC class II transactivator
TaxID9606
Evidenceevidence at protein level
Length1130
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesCIITA

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000976 transcription cis-regulatory region binding
GO:0003713 transcription coactivator activity
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0008022 protein C-terminus binding
GO:0016605 PML body
GO:0016746 acyltransferase activity
GO:0032966 negative regulation of collagen biosynthetic process
GO:0034341 response to interferon-gamma
GO:0044877 protein-containing complex binding
GO:0045345 positive regulation of MHC class I biosynthetic process
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046597 negative regulation of viral entry into host cell
GO:0046677 response to antibiotic
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001611 Leucine-rich repeatRepeatRepeat
IPR007111 NACHT nucleoside triphosphataseDomainDomain
IPR008095 MHC class II transactivatorFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
C2TA_HUMANZXDC_HUMANHPRD, UniProt16600381 17493635 details
C2TA_HUMANZXDA_HUMANUniProt17493635 details
C2TA_HUMANRFX5_HUMANBioGRID, HPRD, IntAct10938133 11003667 12697811 26871568 9177217 details
C2TA_HUMANNCOA1_HUMANBioGRID, HPRD12933903 details
C2TA_HUMANRFXK_HUMANBioGRID, HPRD11003667 11463838 details
C2TA_HUMANXPO1_HUMANBioGRID, HPRD12517958 18245089 details
C2TA_HUMANMK01_HUMANBioGRID18245089 details
C2TA_HUMANCDK1_HUMANBioGRID18245089 details
C2TA_HUMANHDAC2_HUMANBioGRID12697811 17991736 19041327 details
C2TA_HUMANHDAC1_HUMANBioGRID12697811 details
C2TA_HUMANSMCA4_HUMANBioGRID12077331 details
C2TA_HUMANGSK3B_HUMANBioGRID17991736 details
C2TA_HUMANPRS8_HUMANBioGRID18215421 20351748 26871568 details
C2TA_HUMANTF2B_HUMANBioGRID9177216 details
C2TA_HUMANTAF9_HUMANBioGRID9177216 details
C2TA_HUMANKAT2B_HUMANBioGRID, HPRD11046145 28286521 details
C2TA_HUMANSIR1_HUMANUniProt21890893 details
C2TA_HUMANMK03_HUMANBioGRID18245089 details
C2TA_HUMANHDAC4_HUMANBioGRID, HPRD15964851 details
C2TA_HUMANHDAC5_HUMANBioGRID, HPRD15964851 details
C2TA_HUMANSIN3B_HUMANBioGRID17991736 details
C2TA_HUMANPRS7_HUMANBioGRID20351748 details
C2TA_HUMANPRS6A_HUMANBioGRID20351748 details
C2TA_HUMANPPARG_HUMANBioGRID17611194 details
C2TA_HUMANEP300_HUMANBioGRID26871568 details
C2TA_HUMANEP400_HUMANBioGRID26871568 details
C2TA_HUMANTBP_HUMANBioGRID26871568 details
C2TA_HUMANTRI22_HUMANBioGRID28555140 details
C2TA_HUMANPML_HUMANBioGRID28555140 details
C2TA_HUMANCCNT1_HUMANBioGRID28555140 details
C2TA_HUMANNFYB_HUMANHPRD11003667 details
C2TA_HUMANKAPCA_HUMANHPRD11416140 details
C2TA_HUMANTAF6_HUMANHPRD9177216 details