Entity Details

Primary name NTF4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP34130
EntryNameNTF4_HUMAN
FullNameNeurotrophin-4
TaxID9606
Evidenceevidence at protein level
Length210
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesNTF4

GO terms

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GOName
GO:0005163 nerve growth factor receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007402 ganglion mother cell fate determination
GO:0007422 peripheral nervous system development
GO:0007613 memory
GO:0007616 long-term memory
GO:0008021 synaptic vesicle
GO:0008052 sensory organ boundary specification
GO:0008083 growth factor activity
GO:0008344 adult locomotory behavior
GO:0008544 epidermis development
GO:0021675 nerve development
GO:0030424 axon
GO:0030425 dendrite
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0038180 nerve growth factor signaling pathway
GO:0042490 mechanoreceptor differentiation
GO:0043524 negative regulation of neuron apoptotic process
GO:0045664 regulation of neuron differentiation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048812 neuron projection morphogenesis
GO:0050804 modulation of chemical synaptic transmission
GO:0060384 innervation
GO:0061193 taste bud development

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR002072 Nerve growth factor-relatedDomainDomain
IPR019846 Nerve growth factor conserved siteSiteConserved site
IPR020408 Nerve growth factor-likeFamilyFamily
IPR020432 Neurotrophin-4FamilyFamily
IPR029034 Cystine-knot cytokineFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
613100 OMIMGlaucoma 1, open angle, O (GLC1O)A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. Disease susceptibility may be associated with variants affecting the gene represented in this entry.