Entity Details

Primary name IL13_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35225
EntryNameIL13_HUMAN
FullNameInterleukin-13
TaxID9606
Evidenceevidence at protein level
Length146
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesIL13

GO terms

Show/Hide Table
GOName
GO:0001774 microglial cell activation
GO:0002639 positive regulation of immunoglobulin production
GO:0005125 cytokine activity
GO:0005144 interleukin-13 receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0009897 external side of plasma membrane
GO:0010155 regulation of proton transport
GO:0010628 positive regulation of gene expression
GO:0019221 cytokine-mediated signaling pathway
GO:0030890 positive regulation of B cell proliferation
GO:0032496 response to lipopolysaccharide
GO:0032723 positive regulation of connective tissue growth factor production
GO:0032733 positive regulation of interleukin-10 production
GO:0033861 negative regulation of NAD(P)H oxidase activity
GO:0035094 response to nicotine
GO:0042116 macrophage activation
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0043032 positive regulation of macrophage activation
GO:0043306 positive regulation of mast cell degranulation
GO:0045471 response to ethanol
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050714 positive regulation of protein secretion
GO:0050728 negative regulation of inflammatory response
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0071260 cellular response to mechanical stimulus
GO:0071635 negative regulation of transforming growth factor beta production
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1901215 negative regulation of neuron death
GO:1901247 negative regulation of lung ciliated cell differentiation
GO:1901251 positive regulation of lung goblet cell differentiation
GO:1903660 negative regulation of complement-dependent cytotoxicity
GO:2000231 positive regulation of pancreatic stellate cell proliferation
GO:2000352 negative regulation of endothelial cell apoptotic process

Subcellular Location

Show/Hide Table
Subcellular Location
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR001325 Interleukin-4/interleukin-13FamilyFamily
IPR009079 Four-helical cytokine-like, coreFamilyHomologous superfamily
IPR018096 Interleukin-4/interleukin-13, conserved siteSiteConserved site
IPR020470 Interleukin-13FamilyFamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
607154 OMIMAllergic rhinitis (ALRH)A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Drugs

Show/Hide Table
DrugNameSourceType
DB05305 Cintredekin BesudotoxDrugbankbiotech
DB11914 LebrikizumabDrugbankbiotech