Entity Details

Primary name RORA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35398
EntryNameRORA_HUMAN
FullNameNuclear receptor ROR-alpha
TaxID9606
Evidenceevidence at protein level
Length523
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesRORA

GO terms

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GOName
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001222 transcription corepressor binding
GO:0001223 transcription coactivator binding
GO:0001525 angiogenesis
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006805 xenobiotic metabolic process
GO:0006809 nitric oxide biosynthetic process
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0008142 oxysterol binding
GO:0008270 zinc ion binding
GO:0008589 regulation of smoothened signaling pathway
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010906 regulation of glucose metabolic process
GO:0019218 regulation of steroid metabolic process
GO:0019221 cytokine-mediated signaling pathway
GO:0021702 cerebellar Purkinje cell differentiation
GO:0021930 cerebellar granule cell precursor proliferation
GO:0030522 intracellular receptor signaling pathway
GO:0032922 circadian regulation of gene expression
GO:0036315 cellular response to sterol
GO:0042632 cholesterol homeostasis
GO:0042692 muscle cell differentiation
GO:0042753 positive regulation of circadian rhythm
GO:0043030 regulation of macrophage activation
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043565 sequence-specific DNA binding
GO:0045599 negative regulation of fat cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046068 cGMP metabolic process
GO:0050728 negative regulation of inflammatory response
GO:0070328 triglyceride homeostasis
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071456 cellular response to hypoxia
GO:0072539 T-helper 17 cell differentiation
GO:0098531 ligand-activated transcription factor activity

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR003079 Nuclear receptor RORFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily
IPR044101 Retinoid-related orphan receptors, DNA-binding domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB01990 Cholesterol sulfateDrugbanksmall molecule
DB04540 CholesterolDrugbanksmall molecule

Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
RORA_HUMANPRS8_HUMANBioGRID, HPRD, IntAct15604093 16189514 16713569 details
RORA_HUMANLMO3_HUMANBioGRID, HPRD, IntAct16713569 details
RORA_HUMANNR0B1_HUMANBioGRID, HPRD, IntAct16713569 details
RORA_HUMANNCOA1_HUMANBioGRID, IntAct15604093 20203100 23975195 details
RORA_HUMANGFAP_HUMANBioGRID, IntAct25416956 details
RORA_HUMANFOXP3_HUMANIntAct18354202 details
RORA_HUMANEP300_HUMANBioGRID, HPRD9862959 details
RORA_HUMANMYOD1_HUMANBioGRID, HPRD9862959 details
RORA_HUMANLRIF1_HUMANBioGRID17455211 details
RORA_HUMANZXDC_HUMANBioGRID, HPRD15604093 details
RORA_HUMANPROX1_HUMANBioGRID, HPRD15604093 details
RORA_HUMANPNRC1_HUMANBioGRID, HPRD15604093 details
RORA_HUMANCSN5_HUMANBioGRID, HPRD15604093 details
RORA_HUMANPNRC2_HUMANBioGRID, HPRD15604093 details
RORA_HUMANSMRD3_HUMANBioGRID, HPRD14701856 details
RORA_HUMANNSD1_HUMANBioGRID23975195 details
RORA_HUMANKC1E_HUMANBioGRID23555304 details
RORA_HUMANBHE41_HUMANBioGRID23555304 details
RORA_HUMANHIF1A_HUMANBioGRID14742449 details
RORA_HUMANSP1_HUMANBioGRID14742449 details
RORA_HUMANMED1_HUMANHPRD10478845 details
RORA_HUMANNCOA2_HUMANHPRD10478845 details
RORA_HUMANNDKA_HUMANHPRD8858107 details
RORA_HUMANNDKB_HUMANHPRD8858107 details
RORA_HUMANRUVB1_HUMANBioGRID, DIP18087039 details
RORA_HUMANCEBPB_HUMANBioGRID19324970 details
RORA_HUMANEZH2_HUMANBioGRID23063525 details
RORA_HUMANDCAF1_HUMANBioGRID23063525 details
RORA_HUMANDDB1_HUMANBioGRID23063525 details
RORA_HUMANPTBP1_HUMANBioGRID23208419 details
RORA_HUMANRORA_HUMANHPRD7935491 details