Entity Details

Primary name HXK4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35557
EntryNameHXK4_HUMAN
FullNameHexokinase-4
TaxID9606
Evidenceevidence at protein level
Length465
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesGCK

GO terms

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GOName
GO:0001678 cellular glucose homeostasis
GO:0004340 glucokinase activity
GO:0005524 ATP binding
GO:0005536 glucose binding
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006096 glycolytic process
GO:0006110 regulation of glycolytic process
GO:0008865 fructokinase activity
GO:0019158 mannokinase activity
GO:0032024 positive regulation of insulin secretion
GO:0032869 cellular response to insulin stimulus
GO:0042593 glucose homeostasis
GO:0044320 cellular response to leptin stimulus
GO:0045721 negative regulation of gluconeogenesis
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0050796 regulation of insulin secretion
GO:0051156 glucose 6-phosphate metabolic process
GO:0051594 detection of glucose
GO:0061621 canonical glycolysis

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR001312 HexokinaseFamilyFamily
IPR019807 Hexokinase, binding siteSiteBinding site
IPR022672 Hexokinase, N-terminalDomainDomain
IPR022673 Hexokinase, C-terminalDomainDomain
IPR039073 Hexokinase-4, chordateFamilyFamily
IPR043129 ATPase, nucleotide binding domainFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01914 D-glucoseSwissprotsmall molecule
DB02379 Beta-D-GlucoseDrugbanksmall molecule
DB07358 2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamideDrugbanksmall molecule
DB07359 3-[(4-fluorophenyl)sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridine-2-carboxamideDrugbanksmall molecule
DB08118 2-(methylamino)-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamideDrugbanksmall molecule
DB08210 2-AMINO-4-FLUORO-5-[(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]-N-(1,3-THIAZOL-2-YL)BENZAMIDEDrugbanksmall molecule
DB09341 Dextrose, unspecified formSwissprotsmall molecule
DB09344 Invert sugarSwissprotsmall molecule