Entity Details

Primary name ACV1B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP36896
EntryNameACV1B_HUMAN
FullNameActivin receptor type-1B
TaxID9606
Evidenceevidence at protein level
Length505
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesACVR1B

GO terms

Show/Hide Table
GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001701 in utero embryonic development
GO:0001942 hair follicle development
GO:0004674 protein serine/threonine kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007399 nervous system development
GO:0007417 central nervous system development
GO:0009986 cell surface
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016361 activin receptor activity, type I
GO:0018107 peptidyl-threonine phosphorylation
GO:0030308 negative regulation of cell growth
GO:0031625 ubiquitin protein ligase binding
GO:0032924 activin receptor signaling pathway
GO:0032927 positive regulation of activin receptor signaling pathway
GO:0034711 inhibin binding
GO:0038092 nodal signaling pathway
GO:0043235 receptor complex
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046332 SMAD binding
GO:0046545 development of primary female sexual characteristics
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0048179 activin receptor complex
GO:0048185 activin binding
GO:0071363 cellular response to growth factor stimulus
GO:0097191 extrinsic apoptotic signaling pathway
GO:1901165 positive regulation of trophoblast cell migration

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000333 Ser/Thr protein kinase, TGFB receptorFamilyFamily
IPR000472 Activin types I and II receptor domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR003605 GS domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00171 ATPDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
ACV1B_HUMANKAPCB_HUMANBioGRID, IntAct21988832 details
ACV1B_HUMANOS9_HUMANBioGRID, IntAct21988832 details
ACV1B_HUMANRXRA_HUMANBioGRID, IntAct21988832 details
ACV1B_HUMANBAG6_HUMANBioGRID, IntAct21988832 details
ACV1B_HUMANFKB1A_HUMANbhf-ucl, BioGRID15908921 16720724 details
ACV1B_HUMANBMPR2_HUMANBioGRID7791754 details
ACV1B_HUMANTDGF1_HUMANBioGRID, HPRD11909953 28126904 details
ACV1B_HUMANNED4L_HUMANBioGRID19953087 details
ACV1B_HUMANBAMBI_HUMANBioGRID19758997 details
ACV1B_HUMANOTUB1_HUMANBioGRID25872870 details
ACV1B_HUMANNODAL_HUMANBioGRID28126904 details
ACV1B_HUMANHS90B_HUMANIntAct22939624 details
ACV1B_HUMANSMAD7_HUMANbhf-ucl, BioGRID, HPRD12023024 16720724 20663871 details
ACV1B_HUMANAVR2B_HUMANBioGRID, HPRD8612709 8622651 details
ACV1B_HUMANINHBB_HUMANBioGRID, HPRD11266516 12032389 15196700 9202237 details
ACV1B_HUMANINHBA_HUMANBioGRID, HPRD8397373 9202237 details
ACV1B_HUMANSMAD2_HUMANBioGRID, HPRD9892009 details
ACV1B_HUMANSMAD3_HUMANBioGRID9892009 details
ACV1B_HUMANAVR2A_HUMANBioGRID11927552 8612709 9892009 details
ACV1B_HUMANACVR1_HUMANBioGRID26186194 8612709 details
ACV1B_HUMANSNX2_HUMANBioGRID, HPRD11279102 details
ACV1B_HUMANSNX1_HUMANBioGRID, HPRD11279102 details
ACV1B_HUMANSMUF1_HUMANBioGRID12857866 16720724 details
ACV1B_HUMANT22D1_HUMANBioGRID21791611 details
ACV1B_HUMANIGSF1_HUMANBioGRID, HPRD11266516 details
ACV1B_HUMANSMAD6_HUMANBioGRID20663871 details
ACV1B_HUMANHS90A_HUMANBioGRID22939624 details
ACV1B_HUMANPEG10_HUMANBioGRID15611116 details
ACV1B_HUMANSMAD4_HUMANHPRD9892009 details
ACV1B_HUMANINHBC_HUMANHPRD12651901 details
ACV1B_HUMANACV1B_HUMANHPRD15196700 details
ACV1B_HUMANTGFA1_HUMANHPRD11278302 details