Entity Details

Primary name ACHA4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP43681
EntryNameACHA4_HUMAN
FullNameNeuronal acetylcholine receptor subunit alpha-4
TaxID9606
Evidenceevidence at protein level
Length627
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesCHRNA4

GO terms

Show/Hide Table
GOName
GO:0001508 action potential
GO:0001666 response to hypoxia
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005892 acetylcholine-gated channel complex
GO:0006281 DNA repair
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0006979 response to oxidative stress
GO:0007165 signal transduction
GO:0007268 chemical synaptic transmission
GO:0007271 synaptic transmission, cholinergic
GO:0009897 external side of plasma membrane
GO:0014059 regulation of dopamine secretion
GO:0015276 ligand-gated ion channel activity
GO:0015464 acetylcholine receptor activity
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0019233 sensory perception of pain
GO:0022848 acetylcholine-gated cation-selective channel activity
GO:0030425 dendrite
GO:0030594 neurotransmitter receptor activity
GO:0034220 ion transmembrane transport
GO:0035094 response to nicotine
GO:0035095 behavioral response to nicotine
GO:0042113 B cell activation
GO:0042166 acetylcholine binding
GO:0042391 regulation of membrane potential
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0050877 nervous system process
GO:0050890 cognition
GO:0051899 membrane depolarization
GO:0060080 inhibitory postsynaptic potential

Subcellular Location

Show/Hide Table
Subcellular Location
Cell junction
Cell membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR002394 Nicotinic acetylcholine receptorFamilyFamily
IPR006029 Neurotransmitter-gated ion-channel transmembrane domainDomainDomain
IPR006201 Neurotransmitter-gated ion-channelFamilyFamily
IPR006202 Neurotransmitter-gated ion-channel ligand-binding domainDomainDomain
IPR018000 Neurotransmitter-gated ion-channel, conserved siteSiteConserved site
IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamilyFamilyHomologous superfamily
IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00184 NicotineDrugbanksmall molecule
DB00237 ButabarbitalDrugbanksmall molecule
DB00241 ButalbitalDrugbanksmall molecule
DB00306 TalbutalDrugbanksmall molecule
DB00312 PentobarbitalDrugbanksmall molecule
DB00333 MethadoneDrugbanksmall molecule
DB00418 SecobarbitalDrugbanksmall molecule
DB00463 MetharbitalDrugbanksmall molecule
DB00514 DextromethorphanDrugbanksmall molecule
DB00564 CarbamazepineDrugbanksmall molecule
DB00572 AtropineDrugbanksmall molecule
DB00599 ThiopentalDrugbanksmall molecule
DB00657 MecamylamineDrugbanksmall molecule
DB00747 ScopolamineDrugbanksmall molecule
DB00753 IsofluraneDrugbanksmall molecule
DB00783 EstradiolDrugbanksmall molecule
DB00794 PrimidoneDrugbanksmall molecule
DB00849 MethylphenobarbitalDrugbanksmall molecule
DB00898 EthanolDrugbanksmall molecule
DB00915 AmantadineDrugbanksmall molecule
DB00981 PhysostigmineDrugbanksmall molecule
DB01174 PhenobarbitalDrugbanksmall molecule
DB01245 DecamethoniumDrugbanksmall molecule
DB01273 VareniclineDrugbanksmall molecule
DB01351 AmobarbitalDrugbanksmall molecule
DB01352 AprobarbitalDrugbanksmall molecule
DB01353 ButobarbitalDrugbanksmall molecule
DB01354 HeptabarbitalDrugbanksmall molecule
DB01355 HexobarbitalDrugbanksmall molecule
DB01483 BarbitalDrugbanksmall molecule
DB01496 Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedioneDrugbanksmall molecule
DB05458 PozaniclineDrugbanksmall molecule
DB05740 RPI-78MDrugbanksmall molecule
DB07720 EpibatidineDrugbanksmall molecule
DB09028 CytisineDrugbanksmall molecule
DB13952 Estradiol acetateDrugbanksmall molecule
DB13953 Estradiol benzoateDrugbanksmall molecule
DB13954 Estradiol cypionateDrugbanksmall molecule
DB13955 Estradiol dienanthateDrugbanksmall molecule
DB13956 Estradiol valerateDrugbanksmall molecule