Entity Details

Primary name ABCG1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP45844
EntryNameABCG1_HUMAN
FullNameATP-binding cassette sub-family G member 1
TaxID9606
Evidenceevidence at protein level
Length678
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesABCG1

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0005524 ATP binding
GO:0005543 phospholipid binding
GO:0005739 mitochondrion
GO:0005768 endosome
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0006869 lipid transport
GO:0008203 cholesterol metabolic process
GO:0009897 external side of plasma membrane
GO:0010033 response to organic substance
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010872 regulation of cholesterol esterification
GO:0010887 negative regulation of cholesterol storage
GO:0015485 cholesterol binding
GO:0016021 integral component of membrane
GO:0019534 toxin transmembrane transporter activity
GO:0030522 intracellular receptor signaling pathway
GO:0032367 intracellular cholesterol transport
GO:0033344 cholesterol efflux
GO:0033700 phospholipid efflux
GO:0033993 response to lipid
GO:0034041 ABC-type sterol transporter activity
GO:0034374 low-density lipoprotein particle remodeling
GO:0034375 high-density lipoprotein particle remodeling
GO:0034436 glycoprotein transport
GO:0042632 cholesterol homeostasis
GO:0042803 protein homodimerization activity
GO:0042987 amyloid precursor protein catabolic process
GO:0043531 ADP binding
GO:0043691 reverse cholesterol transport
GO:0045542 positive regulation of cholesterol biosynthetic process
GO:0046982 protein heterodimerization activity
GO:0050714 positive regulation of protein secretion
GO:0055037 recycling endosome
GO:0055091 phospholipid homeostasis
GO:0090554 phosphatidylcholine floppase activity
GO:0120020 cholesterol transfer activity
GO:0140328 floppase activity
GO:1902004 positive regulation of amyloid-beta formation

Subcellular Location

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Subcellular Location
Cell membrane
Endoplasmic reticulum membrane
Golgi apparatus membrane

Domains

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DomainNameCategoryType
IPR003439 ABC transporter-like, ATP-binding domainDomainDomain
IPR003593 AAA+ ATPase domainDomainDomain
IPR005284 Pigment precursor permease/Protein ATP-binding cassette sub-family GFamilyFamily
IPR013525 ABC-2 type transporterDomainDomain
IPR017871 ABC transporter-like, conserved siteSiteConserved site
IPR020064 ABC transporter, G1FamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR043926 ABC transporter family G domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00163 Vitamin EDrugbanksmall molecule
DB00171 ATPDrugbanksmall molecule