Entity Details

Primary name AL1A3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP47895
EntryNameAL1A3_HUMAN
FullNameAldehyde dehydrogenase family 1 member A3
TaxID9606
Evidenceevidence at protein level
Length512
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesALDH1A3

GO terms

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GOName
GO:0001758 retinal dehydrogenase activity
GO:0002072 optic cup morphogenesis involved in camera-type eye development
GO:0002138 retinoic acid biosynthetic process
GO:0004029 aldehyde dehydrogenase (NAD+) activity
GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0007626 locomotory behavior
GO:0021768 nucleus accumbens development
GO:0031076 embryonic camera-type eye development
GO:0042472 inner ear morphogenesis
GO:0042572 retinol metabolic process
GO:0042573 retinoic acid metabolic process
GO:0042574 retinal metabolic process
GO:0042803 protein homodimerization activity
GO:0043065 positive regulation of apoptotic process
GO:0048048 embryonic eye morphogenesis
GO:0050885 neuromuscular process controlling balance
GO:0051289 protein homotetramerization
GO:0060013 righting reflex
GO:0060166 olfactory pit development
GO:0060324 face development
GO:0070062 extracellular exosome
GO:0070324 thyroid hormone binding
GO:0070384 Harderian gland development
GO:0070403 NAD+ binding

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR015590 Aldehyde dehydrogenase domainDomainDomain
IPR016160 Aldehyde dehydrogenase, cysteine active siteSiteConserved site
IPR016161 Aldehyde/histidinol dehydrogenaseFamilyHomologous superfamily
IPR016162 Aldehyde dehydrogenase, N-terminalFamilyHomologous superfamily
IPR016163 Aldehyde dehydrogenase, C-terminalFamilyHomologous superfamily
IPR029510 Aldehyde dehydrogenase, glutamic acid active siteSiteConserved site

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB00162 Vitamin ADrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
AL1A3_HUMANUSP9X_HUMANBioGRID30958800 details