Entity Details

Primary name DNLI3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49916
EntryNameDNLI3_HUMAN
FullNameDNA ligase 3
TaxID9606
Evidenceevidence at protein level
Length1009
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesLIG3

GO terms

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GOName
GO:0000724 double-strand break repair via homologous recombination
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0006266 DNA ligation
GO:0006273 lagging strand elongation
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006287 base-excision repair, gap-filling
GO:0006288 base-excision repair, DNA ligation
GO:0006297 nucleotide-excision repair, DNA gap filling
GO:0006302 double-strand break repair
GO:0007005 mitochondrion organization
GO:0007049 cell cycle
GO:0008270 zinc ion binding
GO:0043504 mitochondrial DNA repair
GO:0051301 cell division
GO:0070421 DNA ligase III-XRCC1 complex
GO:0071897 DNA biosynthetic process
GO:0090298 negative regulation of mitochondrial DNA replication
GO:0097681 double-strand break repair via alternative nonhomologous end joining

Subcellular Location

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Subcellular Location
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR000977 DNA ligase, ATP-dependentFamilyFamily
IPR001357 BRCT domainDomainDomain
IPR001510 Zinc finger, PARP-typeDomainDomain
IPR012308 DNA ligase, ATP-dependent, N-terminalDomainDomain
IPR012309 DNA ligase, ATP-dependent, C-terminalDomainDomain
IPR012310 DNA ligase, ATP-dependent, centralDomainDomain
IPR012340 Nucleic acid-binding, OB-foldFamilyHomologous superfamily
IPR016059 DNA ligase, ATP-dependent, conserved siteSiteConserved site
IPR031916 DNA ligase 3, BRCT domainDomainDomain
IPR036420 BRCT domain superfamilyFamilyHomologous superfamily
IPR036599 DNA ligase, ATP-dependent, N-terminal domain superfamilyFamilyHomologous superfamily
IPR036957 Zinc finger, PARP-type superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00290 BleomycinDrugbanksmall molecule