Entity Details

Primary name PLCD1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP51178
EntryNamePLCD1_HUMAN
FullName1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
TaxID9606
Evidenceevidence at protein level
Length756
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesPLCD1

GO terms

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GOName
GO:0001786 phosphatidylserine binding
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0005509 calcium ion binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0006644 phospholipid metabolic process
GO:0016042 lipid catabolic process
GO:0032794 GTPase activating protein binding
GO:0043647 inositol phosphate metabolic process
GO:0046488 phosphatidylinositol metabolic process
GO:0048015 phosphatidylinositol-mediated signaling
GO:0070062 extracellular exosome
GO:0070300 phosphatidic acid binding

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000909 Phosphatidylinositol-specific phospholipase C, X domainDomainDomain
IPR001192 Phosphoinositide phospholipase C familyFamilyFamily
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR002048 EF-hand domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR015359 Phosphoinositide-specific phospholipase C, EF-hand-like domainDomainDomain
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamilyFamilyHomologous superfamily
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR028391 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1FamilyFamily
IPR035892 C2 domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
151600 OMIMNail disorder, non-syndromic congenital, 3 (NDNC3)A nail disorder characterized by a white appearance of the nail plate (true leukonychia), the nail bed (pseudoleukonychia), or neither (apparent leukonychia). Leukonychia may involve all of the nail (leukonychia totalis) or only part of the nail (leukonychia partialis), or can appear as one or more transverse bands (leukonychia striata) or white spots (leukonychia punctata). The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB03401 1D-myo-inositol 1,4,5-trisphosphateDrugbanksmall molecule
DB03956 Inositol 2,4,5-trisphosphateDrugbanksmall molecule