Entity Details

Primary name BRCA2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP51587
EntryNameBRCA2_HUMAN
FullNameBreast cancer type 2 susceptibility protein
TaxID9606
Evidenceevidence at protein level
Length3418
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesBRCA2

GO terms

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GOName
GO:0000722 telomere maintenance via recombination
GO:0000724 double-strand break repair via homologous recombination
GO:0000781 chromosome, telomeric region
GO:0000800 lateral element
GO:0001556 oocyte maturation
GO:0001833 inner cell mass cell proliferation
GO:0002020 protease binding
GO:0003697 single-stranded DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0006289 nucleotide-excision repair
GO:0006302 double-strand break repair
GO:0006355 regulation of transcription, DNA-templated
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007141 male meiosis I
GO:0007283 spermatogenesis
GO:0007420 brain development
GO:0007569 cell aging
GO:0008022 protein C-terminus binding
GO:0008585 female gonad development
GO:0010165 response to X-ray
GO:0010225 response to UV-C
GO:0010332 response to gamma radiation
GO:0010484 H3 histone acetyltransferase activity
GO:0010485 H4 histone acetyltransferase activity
GO:0030097 hemopoiesis
GO:0030141 secretory granule
GO:0032465 regulation of cytokinesis
GO:0032991 protein-containing complex
GO:0033593 BRCA2-MAGE-D1 complex
GO:0033600 negative regulation of mammary gland epithelial cell proliferation
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042802 identical protein binding
GO:0043015 gamma-tubulin binding
GO:0043966 histone H3 acetylation
GO:0043967 histone H4 acetylation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045931 positive regulation of mitotic cell cycle
GO:0048478 replication fork protection
GO:0051298 centrosome duplication
GO:0070200 establishment of protein localization to telomere
GO:1990426 mitotic recombination-dependent replication fork processing

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR002093 BRCA2 repeatRepeatRepeat
IPR012340 Nucleic acid-binding, OB-foldFamilyHomologous superfamily
IPR015187 BRCA2, OB1DomainDomain
IPR015188 BRCA2, OB3DomainDomain
IPR015205 Tower domainDomainDomain
IPR015252 Breast cancer type 2 susceptibility protein, helical domainDomainDomain
IPR015525 Breast cancer type 2 susceptibility proteinFamilyFamily
IPR036315 BRCA2 helical domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

87 interactions

InteractorPartnerSourcesPublicationsLink
BRCA2_HUMANSEM1_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt10373512 12228710 16205630 16239144 22293751 24013206 26145171 26833090 28976962 32609828 details
BRCA2_HUMANRAD51_HUMANBioGRID, DIP, HPRD, I2D, IntAct, MINT10551859 11239456 11313963 11477095 12442171 12606939 12619154 12815053 12941707 14580352 14636569 15065660 15671039 15713648 15800615 15800651 15897881 15937124 16513631 16793542 16914443 17515903 17515904 17541404 18264088 18317453 18429819 19303847 19628690 19875419 20729832 20729859 20871615 21076401 21399666 21601571 21670257 21789034 22116401 22293751 23935068 24013206 24835992 24981860 25282148 25585578 26145171 26387543 26833090 27941124 28168276 28757209 28765325 31113933 9126738 9405383 9523196 9560268 9774970 9811893 details
BRCA2_HUMANFACD2_HUMANBioGRID, HPRD, IntAct15115758 15199141 18212739 18263878 19861535 20450923 28684355 31180492 details
BRCA2_HUMANRFA1_HUMANBioGRID, HPRD, IntAct12527904 details
BRCA2_HUMANDMC1_HUMANBioGRID, DIP, MINT17541404 20729832 26976601 details
BRCA2_HUMANABL1_HUMANIntAct17474147 details
BRCA2_HUMANFYN_HUMANIntAct17474147 details
BRCA2_HUMANGRB2_HUMANIntAct17474147 details
BRCA2_HUMANPALB2_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt16793542 17200672 17420451 19268590 19369211 19553677 19584259 19609323 20332121 20871615 21466675 22193777 22293751 22331464 23038782 23585894 24141787 24485656 24835992 25016020 26649820 26833090 26990772 28240985 28319063 28398198 28765325 30410870 details
BRCA2_HUMANBRCA2_HUMANBioGRID, DIP, MINT21601571 25282148 27433848 28168276 32609828 details
BRCA2_HUMANHM20B_HUMANBioGRID, HPRD, I2D11207365 12032298 21399666 25486196 details
BRCA2_HUMANBRCA1_HUMANBioGRID, DIP, HPRD, MINT, UniProt11477095 14499622 14636569 17664283 19369211 21135251 22193777 24085845 25184681 25652403 29656893 9774970 details
BRCA2_HUMANPDS5B_HUMANBioGRID, MINT22293751 27924011 details
BRCA2_HUMANPOLH_HUMANBioGRID, UniProt24485656 details
BRCA2_HUMANP53_HUMANBioGRID, DIP, HPRD14636569 20421506 32807901 9811893 details
BRCA2_HUMANXPO1_HUMANBioGRID, DIP24013206 details
BRCA2_HUMANUBP11_HUMANBioGRID, DIP15314155 26649820 details
BRCA2_HUMANTP53B_HUMANBioGRID, UniProt20010693 29656893 details
BRCA2_HUMANEMSY_HUMANBioGRID, HPRD14651845 details
BRCA2_HUMANFANCG_HUMANBioGRID, HPRD12915460 16621732 18212739 20450923 details
BRCA2_HUMANSEML_HUMANBioGRID10373512 12228710 16205630 16239144 26145171 26833090 28976962 32609828 details
BRCA2_HUMANBARD1_HUMANBioGRID14636569 16391231 17664283 19176389 details
BRCA2_HUMANBCCIP_HUMANBioGRID, HPRD11313963 15713648 details
BRCA2_HUMANKAT2B_HUMANBioGRID, HPRD12815053 28985013 9824164 details
BRCA2_HUMANSMAD3_HUMANBioGRID, HPRD12165866 details
BRCA2_HUMANPLK1_HUMANBioGRID, HPRD12815053 14647413 24448238 24835992 28985013 details
BRCA2_HUMANBUB1B_HUMANBioGRID, HPRD10749118 28985013 details
BRCA2_HUMANFLNA_HUMANBioGRID, HPRD11602572 details
BRCA2_HUMANATR_HUMANBioGRID10608806 details
BRCA2_HUMANATM_HUMANBioGRID15199141 details
BRCA2_HUMANCHK2_HUMANBioGRID14623252 17525332 18317453 details
BRCA2_HUMANSERPH_HUMANBioGRID19578754 details
BRCA2_HUMANUQCC1_HUMANBioGRID19578754 details
BRCA2_HUMANH2AX_HUMANBioGRID18406329 20936109 details
BRCA2_HUMANMAGD1_HUMANBioGRID15930293 details
BRCA2_HUMANNEDD4_HUMANBioGRID15001356 details
BRCA2_HUMANCDK2_HUMANBioGRID, HPRD15800615 15800651 24835992 26387543 details
BRCA2_HUMANCCNA2_HUMANBioGRID, HPRD15800615 15800651 details
BRCA2_HUMANERCC5_HUMANBioGRID26833090 details
BRCA2_HUMANFANCI_HUMANBioGRID28684355 details
BRCA2_HUMANUBP21_HUMANBioGRID28743957 details
BRCA2_HUMANDC1L2_HUMANBioGRID27433848 details
BRCA2_HUMANDC1L1_HUMANBioGRID27433848 details
BRCA2_HUMANPLEC_HUMANBioGRID19709076 details
BRCA2_HUMANLIMD1_HUMANBioGRID27656835 details
BRCA2_HUMANCCND1_HUMANBioGRID21654808 26387543 details
BRCA2_HUMANRNH2A_HUMANBioGRID30560944 details
BRCA2_HUMANWTIP_HUMANBioGRID27535760 details
BRCA2_HUMANCCNA1_HUMANBioGRID26387543 details
BRCA2_HUMANCHK1_HUMANBioGRID18317453 details
BRCA2_HUMANRD23A_HUMANBioGRID, MINT16712842 details
BRCA2_HUMANRFA2_HUMANBioGRID, IntAct12527904 25113031 details
BRCA2_HUMANSYCP3_HUMANMINT22116401 details
BRCA2_HUMANXRCC3_HUMANBioGRID, IntAct, UniProt16621732 18212739 20450923 24141787 26496610 details
BRCA2_HUMANBABA2_HUMANBioGRID14636569 details
BRCA2_HUMANBRCC3_HUMANBioGRID14636569 17664283 details
BRCA2_HUMANSMAD2_HUMANBioGRID12165866 details
BRCA2_HUMANFANCE_HUMANBioGRID, HPRD15199141 details
BRCA2_HUMANSTA5A_HUMANBioGRID, HPRD12459499 details
BRCA2_HUMANAURKB_HUMANBioGRID19176389 details
BRCA2_HUMANPMS2_HUMANBioGRID17148452 details
BRCA2_HUMANPMS1_HUMANBioGRID17148452 details
BRCA2_HUMANMCPH1_HUMANBioGRID19549900 20107607 details
BRCA2_HUMANSP1_HUMANBioGRID18769160 details
BRCA2_HUMANKIF4A_HUMANBioGRID18604178 details
BRCA2_HUMANMO4L1_HUMANBioGRID20332121 26186194 details
BRCA2_HUMANMGMT_HUMANBioGRID19047179 details
BRCA2_HUMANPSMD3_HUMANBioGRID17563742 details
BRCA2_HUMANPSMD6_HUMANBioGRID17563742 details
BRCA2_HUMANCFA52_HUMANBioGRID, HPRD15967112 details
BRCA2_HUMANKEAP1_HUMANBioGRID22331464 28416489 details
BRCA2_HUMANDPOLN_HUMANBioGRID26269593 details
BRCA2_HUMANRN168_HUMANBioGRID28240985 details
BRCA2_HUMANPP2AA_HUMANBioGRID28985013 details
BRCA2_HUMANUIMC1_HUMANBioGRID29499138 details
BRCA2_HUMANRPB1_HUMANBioGRID29386125 details
BRCA2_HUMANMYH14_HUMANBioGRID24448238 details
BRCA2_HUMANFANCJ_HUMANBioGRID17664283 details
BRCA2_HUMANNPM_HUMANBioGRID21084279 details
BRCA2_HUMANROCK2_HUMANBioGRID21084279 details
BRCA2_HUMANETAA1_HUMANBioGRID27723720 details
BRCA2_HUMANTRI29_HUMANBioGRID26095369 details
BRCA2_HUMANCT55_HUMANBioGRID18307534 details
BRCA2_HUMANCCNB1_HUMANBioGRID26387543 details
BRCA2_HUMANRAD50_HUMANBioGRID20010693 details
BRCA2_HUMANCCNE1_HUMANHPRD15800651 details
BRCA2_HUMANCDK1_HUMANHPRD15800651 details