Entity Details

Primary name NEK4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP51957
EntryNameNEK4_HUMAN
FullNameSerine/threonine-protein kinase Nek4
TaxID9606
Evidenceevidence at protein level
Length841
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesNEK4

GO terms

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GOName
GO:0000278 mitotic cell cycle
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0030145 manganese ion binding
GO:0035253 ciliary rootlet
GO:0035869 ciliary transition zone
GO:0036064 ciliary basal body
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051301 cell division
GO:0097014 ciliary plasm
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:2000772 regulation of cellular senescence
GO:2001020 regulation of response to DNA damage stimulus

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule