Entity Details

Primary name VAV2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP52735
EntryNameVAV2_HUMAN
FullNameGuanine nucleotide exchange factor VAV2
TaxID9606
Evidenceevidence at protein level
Length878
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesVAV2

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001784 phosphotyrosine residue binding
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005154 epidermal growth factor receptor binding
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0008361 regulation of cell size
GO:0016477 cell migration
GO:0030032 lamellipodium assembly
GO:0030168 platelet activation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043065 positive regulation of apoptotic process
GO:0043087 regulation of GTPase activity
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0046872 metal ion binding
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0051056 regulation of small GTPase mediated signal transduction

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000219 Dbl homology (DH) domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved siteSiteConserved site
IPR001452 SH3 domainDomainDomain
IPR001715 Calponin homology domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domainDomainDomain
IPR035732 VAV2 protein, second SH3 domainDomainDomain
IPR035733 VAV2 protein, first SH3 domainDomainDomain
IPR035880 VAV2, SH2 domainDomainDomain
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR036872 CH domain superfamilyFamilyHomologous superfamily
IPR037832 Vav, PH domainDomainDomain

Diseases

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Interactions

76 interactions

InteractorPartnerSourcesPublicationsLink
VAV2_HUMANNEK3_HUMANHPRD, UniProt15618286 details
VAV2_HUMANERBB2_HUMANBioGRID, MINT16273093 22973453 details
VAV2_HUMANERBB3_HUMANBioGRID, MINT16273093 22973453 details
VAV2_HUMAN3BP2_HUMANHPRD, MINT11390470 15345594 details
VAV2_HUMANCBL_HUMANBioGRID, HPRD, MINT11262396 11313921 15345594 20940296 details
VAV2_HUMANKSYK_HUMANBioGRID, HPRD, MINT11262396 15345594 details
VAV2_HUMANCCNO_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANIF4G3_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANBRDT_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANF10A1_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANRBBP6_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANVCIP1_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANTM1L1_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANBD1L1_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANPNMA1_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANFNTA_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANSRRT_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANTCP11_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANMARH7_HUMANBioGRID, IntAct18654987 30008934 details
VAV2_HUMANHS105_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANUBP38_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANBZW1_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANPAIRB_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANUBE4B_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANGAPD1_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANPOGZ_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANMRGBP_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANSF3A3_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANTRBP2_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANSNW1_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANIPO4_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANFUCO_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANCHMP3_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANNCKP5_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANMED21_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANCE170_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANRD23A_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANDJC21_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANHNRPF_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANTITIN_HUMANBioGRID, IntAct18654987 23414517 details
VAV2_HUMANDCNL4_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANTCPG_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANSTK24_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANPPM1B_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANPHF10_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANARI1_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANSRPK2_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANBIRC6_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANRPC9_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANTCPB_HUMANBioGRID, IntAct18654987 details
VAV2_HUMANABI1_HUMANMINT20598684 details
VAV2_HUMANEGFR_HUMANBioGRID, HPRD, MINT10618391 10938113 11516622 12454019 18271526 19531499 20940296 22973453 24797263 details
VAV2_HUMANANDR_HUMANBioGRID, IntAct24728074 details
VAV2_HUMANGAB1_HUMANBioGRID, IntAct24728074 details
VAV2_HUMANMET_HUMANBioGRID, IntAct24728074 details
VAV2_HUMANTXNIP_HUMANMINT26919541 details
VAV2_HUMANCAV1_HUMANBioGRID, DIP20808760 details
VAV2_HUMANCD19_HUMANBioGRID, HPRD11080163 details
VAV2_HUMANFYN_HUMANBioGRID11262396 details
VAV2_HUMANCBLB_HUMANBioGRID9399639 details
VAV2_HUMANS12A6_HUMANBioGRID23724134 details
VAV2_HUMANERBB4_HUMANBioGRID22973453 details
VAV2_HUMANTMG4_HUMANBioGRID23873930 details
VAV2_HUMANGRB2_HUMANBioGRID, HPRD, IntAct11606575 12577067 details
VAV2_HUMANPRLR_HUMANHPRD, UniProt15618286 details
VAV2_HUMANSF01_HUMANIntAct26420826 details
VAV2_HUMANEPHA4_HUMANIntAct31413325 details
VAV2_HUMANSOCS1_HUMANBioGRID, HPRD10022833 29991678 details
VAV2_HUMANPGFRB_HUMANBioGRID10938113 details
VAV2_HUMANCD44_HUMANBioGRID, HPRD11606575 details
VAV2_HUMANCTND1_HUMANBioGRID25657827 details
VAV2_HUMANRHOA_HUMANHPRD11909943 details
VAV2_HUMANRHOG_HUMANHPRD11909943 12376551 details
VAV2_HUMANVAV2_HUMANHPRD12376551 details
VAV2_HUMANEPHB2_HUMANHPRD15848800 details
VAV2_HUMANRAC1_HUMANHPRD16397238 details