Entity Details

Primary name HMCS2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP54868
EntryNameHMCS2_HUMAN
FullNameHydroxymethylglutaryl-CoA synthase, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length508
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesHMGCS2

GO terms

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GOName
GO:0004421 hydroxymethylglutaryl-CoA synthase activity
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0006084 acetyl-CoA metabolic process
GO:0006695 cholesterol biosynthetic process
GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway
GO:0019222 regulation of metabolic process
GO:0042802 identical protein binding
GO:0046951 ketone body biosynthetic process

Subcellular Location

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Subcellular Location
Mitochondrion

Domains

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DomainNameCategoryType
IPR000590 Hydroxymethylglutaryl-coenzyme A synthase, active siteSiteActive site
IPR010122 Hydroxymethylglutaryl-CoA synthase, eukaryoticFamilyFamily
IPR013528 Hydroxymethylglutaryl-coenzyme A synthase, N-terminalDomainDomain
IPR013746 Hydroxymethylglutaryl-coenzyme A synthase, C-terminal domainDomainDomain
IPR016039 Thiolase-likeFamilyHomologous superfamily

Diseases

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Interactions

4 interactions