Entity Details

Primary name DSRAD_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP55265
EntryNameDSRAD_HUMAN
FullNameDouble-stranded RNA-specific adenosine deaminase
TaxID9606
Evidenceevidence at protein level
Length1226
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesADAR

GO terms

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GOName
GO:0001649 osteoblast differentiation
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002566 somatic diversification of immune receptors via somatic mutation
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0003726 double-stranded RNA adenosine deaminase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0006382 adenosine to inosine editing
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0006606 protein import into nucleus
GO:0006611 protein export from nucleus
GO:0008251 tRNA-specific adenosine deaminase activity
GO:0009615 response to virus
GO:0016020 membrane
GO:0016553 base conversion or substitution editing
GO:0030218 erythrocyte differentiation
GO:0031054 pre-miRNA processing
GO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA
GO:0035455 response to interferon-alpha
GO:0043066 negative regulation of apoptotic process
GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0044530 supraspliceosomal complex
GO:0045070 positive regulation of viral genome replication
GO:0045087 innate immune response
GO:0046872 metal ion binding
GO:0051607 defense response to virus
GO:0060216 definitive hemopoiesis
GO:0060337 type I interferon signaling pathway
GO:0060339 negative regulation of type I interferon-mediated signaling pathway
GO:0061484 hematopoietic stem cell homeostasis
GO:0098586 cellular response to virus
GO:1900369 negative regulation of RNA interference

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR002466 Adenosine deaminase/editaseDomainDomain
IPR014720 Double-stranded RNA-binding domainDomainDomain
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily
IPR042371 Z-binding domainDomainDomain
IPR044456 ADAR1, first double-stranded RNA binding domainDomainDomain
IPR044457 ADAR1, third double-stranded RNA binding domainDomainDomain

Diseases

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