Entity Details

Primary name FOXA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP55317
EntryNameFOXA1_HUMAN
FullNameHepatocyte nuclear factor 3-alpha
TaxID9606
Evidenceevidence at protein level
Length472
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesFOXA1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001650 fibrillar center
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005902 microvillus
GO:0006338 chromatin remodeling
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007219 Notch signaling pathway
GO:0008134 transcription factor binding
GO:0009653 anatomical structure morphogenesis
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0019904 protein domain specific binding
GO:0021904 dorsal/ventral neural tube patterning
GO:0030154 cell differentiation
GO:0032355 response to estradiol
GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway
GO:0042445 hormone metabolic process
GO:0042593 glucose homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0045666 positive regulation of neuron differentiation
GO:0045880 positive regulation of smoothened signaling pathway
GO:0045931 positive regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048665 neuron fate specification
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060487 lung epithelial cell differentiation
GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:0060738 epithelial-mesenchymal signaling involved in prostate gland development
GO:0060740 prostate gland epithelium morphogenesis
GO:0060741 prostate gland stromal morphogenesis
GO:0060743 epithelial cell maturation involved in prostate gland development
GO:0061144 alveolar secondary septum development
GO:0071542 dopaminergic neuron differentiation
GO:1902691 respiratory basal cell differentiation
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001766 Fork head domainDomainDomain
IPR013638 Fork-head N-terminalDomainDomain
IPR018122 Fork head domain conserved site1SiteConserved site
IPR018533 Forkhead box protein, C-terminalDomainDomain
IPR030456 Fork head domain conserved site 2SiteConserved site
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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