Entity Details

Primary name ARP2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP61160
EntryNameARP2_HUMAN
FullNameActin-related protein 2
TaxID9606
Evidenceevidence at protein level
Length394
SequenceStatuscomplete
DateCreated2004-05-10
DateModified2021-06-02

Ontological Relatives

GenesACTR2

GO terms

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GOName
GO:0003779 actin binding
GO:0005200 structural constituent of cytoskeleton
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005885 Arp2/3 protein complex
GO:0005925 focal adhesion
GO:0007163 establishment or maintenance of cell polarity
GO:0008306 associative learning
GO:0008356 asymmetric cell division
GO:0010592 positive regulation of lamellipodium assembly
GO:0014069 postsynaptic density
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0016344 meiotic chromosome movement towards spindle pole
GO:0016482 cytosolic transport
GO:0030027 lamellipodium
GO:0030478 actin cap
GO:0033206 meiotic cytokinesis
GO:0034314 Arp2/3 complex-mediated actin nucleation
GO:0035578 azurophil granule lumen
GO:0035861 site of double-strand break
GO:0035902 response to immobilization stress
GO:0035984 cellular response to trichostatin A
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043312 neutrophil degranulation
GO:0045471 response to ethanol
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048013 ephrin receptor signaling pathway
GO:0051653 spindle localization
GO:0060271 cilium assembly
GO:0061003 positive regulation of dendritic spine morphogenesis
GO:0061024 membrane organization
GO:0061825 podosome core
GO:0070062 extracellular exosome
GO:0071346 cellular response to interferon-gamma
GO:1904813 ficolin-1-rich granule lumen
GO:1905168 positive regulation of double-strand break repair via homologous recombination

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR004000 Actin familyFamilyFamily
IPR020902 Actin/actin-like conserved siteSiteConserved site
IPR043129 ATPase, nucleotide binding domainFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB08235 N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamideDrugbanksmall molecule
DB08236 (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-oneDrugbanksmall molecule

Interactions

24 interactions

InteractorPartnerSourcesPublicationsLink
ARP2_HUMANBMP2_HUMANBioGRID10880444 details
ARP2_HUMANELF5_HUMANBioGRID, IntAct21988832 details
ARP2_HUMANSRC8_HUMANBioGRID, IntAct11018051 12732638 26496610 details
ARP2_HUMANERCC6_HUMANBioGRID31722399 details
ARP2_HUMANWASL_HUMANBioGRID, MINT12732638 15834156 details
ARP2_HUMANERPG3_HUMANBioGRID31722399 details
ARP2_HUMANSHRPN_HUMANBioGRID28775156 details
ARP2_HUMANARC1B_HUMANBioGRID, DIP, HPRD, IntAct11721045 11741539 20404198 22863883 22939629 24981860 26186194 26344197 26496610 26655834 28514442 29568061 details
ARP2_HUMANARPC4_HUMANBioGRID, HPRD, IntAct, MINT11721045 11741539 22863883 22939629 24981860 26344197 26496610 29568061 details
ARP2_HUMANHCLS1_HUMANHPRD12534372 details
ARP2_HUMANARPC5_HUMANBioGRID, DIP, HPRD, IntAct, MINT11721045 11741539 22939629 24981860 26344197 26496610 26655834 29568061 details
ARP2_HUMANIQGA2_HUMANHPRD12515716 details
ARP2_HUMANARP3_HUMANBioGRID, HPRD, IntAct11721045 11741539 22863883 22939629 24981860 26344197 26496610 28514442 29568061 34079125 details
ARP2_HUMANTNIK_HUMANIntAct17353931 details
ARP2_HUMANESR1_HUMANBioGRID, IntAct20308691 21182205 details
ARP2_HUMANPOTEF_HUMANBioGRID28775156 details
ARP2_HUMANBCAR3_HUMANIntAct17353931 details
ARP2_HUMANACTB_HUMANBioGRID20308691 details
ARP2_HUMANWASF2_HUMANHPRD9889097 details
ARP2_HUMANHLAB_HUMANIntAct17353931 details
ARP2_HUMANWASF1_HUMANHPRD15834156 details
ARP2_HUMANACTC_HUMANHPRD12019562 details
ARP2_HUMANTRAF6_HUMANIntAct17353931 details
ARP2_HUMANEIF1B_HUMANIntAct17353931 details