Entity Details

Primary name PRS4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP62191
EntryNamePRS4_HUMAN
FullName26S proteasome regulatory subunit 4
TaxID9606
Evidenceevidence at protein level
Length440
SequenceStatuscomplete
DateCreated2004-06-21
DateModified2021-06-02

Ontological Relatives

GenesPSMC1

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000209 protein polyubiquitination
GO:0000502 proteasome complex
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0003723 RNA binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006457 protein folding
GO:0006521 regulation of cellular amino acid metabolic process
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
GO:0016020 membrane
GO:0016579 protein deubiquitination
GO:0016887 ATP hydrolysis activity
GO:0017025 TBP-class protein binding
GO:0022624 proteasome accessory complex
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0036388 pre-replicative complex assembly
GO:0036402 proteasome-activating activity
GO:0038061 NIK/NF-kappaB signaling
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043488 regulation of mRNA stability
GO:0043687 post-translational protein modification
GO:0050852 T cell receptor signaling pathway
GO:0055085 transmembrane transport
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070498 interleukin-1-mediated signaling pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1901215 negative regulation of neuron death
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1902036 regulation of hematopoietic stem cell differentiation

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR003593 AAA+ ATPase domainDomainDomain
IPR003959 ATPase, AAA-type, coreDomainDomain
IPR003960 ATPase, AAA-type, conserved siteSiteConserved site
IPR005937 26S proteasome regulatory subunit P45-likeFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR032501 Proteasomal ATPase OB C-terminal domainDomainDomain
IPR035244 26S Proteasome regulatory subunit 4FamilyFamily
IPR041569 AAA ATPase, AAA+ lid domainDomainDomain

Diseases

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Interactions

72 interactions

InteractorPartnerSourcesPublicationsLink
PRS4_HUMANPSMD2_HUMANBioGRID, HPRD, IntAct10625621 16189514 19060904 19490896 22863883 22901813 22939629 25416956 26344197 26496610 28292943 28514442 30217970 32296183 details
PRS4_HUMANPRS6B_HUMANBioGRID, IntAct17353931 19490896 20810900 21628461 22275368 22863883 22939629 26344197 26496610 28292943 28514442 details
PRS4_HUMANPSMD5_HUMANBioGRID, HPRD, IntAct10625621 19490896 22901813 22939629 25416956 26344197 26496610 28514442 30217970 31515488 32296183 details
PRS4_HUMANPRS7_HUMANBioGRID, HPRD, IntAct10625621 11361004 19490896 21628461 22863883 22901813 22921402 22939629 26186194 26344197 26496610 28292943 28514442 30217970 details
PRS4_HUMANSODC_HUMANBioGRID, IntAct29128334 32814053 details
PRS4_HUMANTERA_HUMANBioGRID, HPRD, IntAct32814053 9452483 details
PRS4_HUMANSUMO2_HUMANBioGRID32786267 details
PRS4_HUMANCC85B_HUMANBioGRID, HPRD, IntAct16189514 details
PRS4_HUMANPSMD1_HUMANBioGRID, IntAct19490896 19589775 22863883 22939629 26344197 26496610 28292943 28514442 details
PRS4_HUMANKDM1A_HUMANBioGRID, MINT23455924 details
PRS4_HUMANJHD2C_HUMANBioGRID, MINT23455924 details
PRS4_HUMANUBQL2_HUMANBioGRID25666615 30442662 details
PRS4_HUMANATX7_HUMANBioGRID, HPRD11734547 details
PRS4_HUMANPSA7_HUMANBioGRID, HPRD11361004 22939629 26344197 28292943 details
PRS4_HUMANPRS8_HUMANBioGRID, IntAct11361004 19490896 21628461 22275368 22939629 26186194 26344197 26496610 28292943 28514442 details
PRS4_HUMANZBT8A_HUMANBioGRID, IntAct25416956 details
PRS4_HUMANPRKN_HUMANBioGRID23503661 25666615 details
PRS4_HUMANCNOT7_HUMANBioGRID30217970 details
PRS4_HUMANUBS3A_HUMANBioGRID31659016 details
PRS4_HUMANMEOX2_HUMANBioGRID, IntAct25416956 details
PRS4_HUMANMAGA2_HUMANBioGRID, IntAct32296183 details
PRS4_HUMANUBCP1_HUMANBioGRID27880917 28539385 details
PRS4_HUMANPIAS3_HUMANBioGRID, MINT21900206 details
PRS4_HUMANHSPB1_HUMANBioGRID, IntAct25277244 details
PRS4_HUMANSYUA_HUMANIntAct32814053 details
PRS4_HUMANPSA4_HUMANBioGRID22939629 26344197 28292943 details
PRS4_HUMANSUV91_HUMANBioGRID, MINT23455924 details
PRS4_HUMANFKBP8_HUMANBioGRID17573772 19546213 details
PRS4_HUMANOGT1_HUMANBioGRID32994395 details
PRS4_HUMANJMJD6_HUMANBioGRID, MINT23455924 details
PRS4_HUMANSTMN2_HUMANBioGRID30217970 details
PRS4_HUMANLNX1_HUMANBioGRID, IntAct32296183 details
PRS4_HUMANPRS4_HUMANBioGRID28292943 details
PRS4_HUMANA4_HUMANBioGRID21832049 details
PRS4_HUMANPE2R4_HUMANBioGRID, MINT28298427 details
PRS4_HUMANUBC_HUMANBioGRID16196087 28190767 details
PRS4_HUMANMO4L1_HUMANBioGRID30217970 details
PRS4_HUMANCCND3_HUMANBioGRID30217970 details
PRS4_HUMANCRK_HUMANBioGRID, IntAct25814554 details
PRS4_HUMANTOPRS_HUMANBioGRID26872363 details
PRS4_HUMANPAAF1_HUMANBioGRID, HPRD, IntAct15831487 17353931 26496610 details
PRS4_HUMANPSMD4_HUMANBioGRID, DIP, IntAct, MINT16990800 22863883 22939629 23209776 24121268 26344197 26496610 30479383 details
PRS4_HUMANPRS10_HUMANBioGRID, DIP, IntAct19490896 22863883 22939629 26186194 26344197 26496610 27342858 28514442 29636472 details
PRS4_HUMANPSMD7_HUMANBioGRID, HPRD, IntAct19615732 22863883 22939629 26186194 26344197 26496610 28514442 6188845 details
PRS4_HUMANPMS2_HUMANBioGRID17148452 details
PRS4_HUMANFGF11_HUMANBioGRID28027390 details
PRS4_HUMANTRM7_HUMANIntAct17353931 details
PRS4_HUMANPSDE_HUMANBioGRID, IntAct17323924 19615732 22863883 22939629 26344197 26496610 27428775 28821611 30745168 details
PRS4_HUMANPSMD8_HUMANBioGRID, IntAct21628461 22275368 22863883 22939629 26344197 26496610 details
PRS4_HUMANSEM1_HUMANBioGRID15610744 16239144 18775730 details
PRS4_HUMANPSA6_HUMANBioGRID16045761 22939629 26344197 details
PRS4_HUMANCSN2_HUMANBioGRID19535905 details
PRS4_HUMANPRS6A_HUMANBioGRID, IntAct21628461 22275368 22863883 22939629 26186194 26344197 26496610 28514442 details
PRS4_HUMANPSME1_HUMANBioGRID12419264 details
PRS4_HUMANPSMD6_HUMANBioGRID, IntAct17353931 22275368 22939629 26344197 26496610 details
PRS4_HUMANTRAF6_HUMANBioGRID, HPRD, IntAct14743216 17353931 details
PRS4_HUMANUBE3A_HUMANBioGRID, IntAct22645313 26496610 29426014 29511261 30257870 details
PRS4_HUMANSRRM2_HUMANBioGRID16159877 details
PRS4_HUMANEF1D_HUMANIntAct20195357 details
PRS4_HUMANPSA3_HUMANBioGRID15837734 22939629 26344197 details
PRS4_HUMANPSA2_HUMANBioGRID15837734 19193609 24121268 26344197 details
PRS4_HUMANPSB5_HUMANBioGRID21628461 22939629 26344197 details
PRS4_HUMANSEML_HUMANBioGRID15610744 16239144 18775730 details
PRS4_HUMANHLAB_HUMANIntAct17353931 details
PRS4_HUMANPMS1_HUMANBioGRID17148452 details
PRS4_HUMANTNIK_HUMANIntAct17353931 details
PRS4_HUMANTRI18_HUMANBioGRID26748699 details
PRS4_HUMANATG5_HUMANIntAct17353931 details
PRS4_HUMANRD23A_HUMANBioGRID19013454 26344197 details
PRS4_HUMANM3K5_HUMANBioGRID20843792 details
PRS4_HUMANTR10D_HUMANIntAct17353931 details
PRS4_HUMANMDM2_HUMANBioGRID20479273 details