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Entity Details
Primary name
SHC2_HUMAN
Entity type
UniProt
Source
Source Link
Details
Accession
P98077
EntryName
SHC2_HUMAN
FullName
SHC-transforming protein 2
TaxID
9606
Evidence
evidence at protein level
Length
582
SequenceStatus
complete
DateCreated
1996-02-01
DateModified
2021-06-02
Ontological Relatives
Genes
SHC2
GO terms
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GO
Name
GO:0000165
MAPK cascade
GO:0000187
obsolete activation of MAPK activity
GO:0005829
cytosol
GO:0005886
plasma membrane
GO:0007169
transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007265
Ras protein signal transduction
GO:0019901
protein kinase binding
GO:0030971
receptor tyrosine kinase binding
GO:0048010
vascular endothelial growth factor receptor signaling pathway
Subcellular Location
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Domains
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Domain
Name
Category
Type
IPR000980
SH2 domain
Domain
Domain
IPR006019
Phosphotyrosine interaction domain, Shc-like
Domain
Domain
IPR006020
PTB/PI domain
Domain
Domain
IPR011993
PH-like domain superfamily
Family
Homologous superfamily
IPR029591
SHC-transforming protein 2
Family
Family
IPR035676
SH2 adaptor protein C, SH2 domain
Domain
Domain
IPR036860
SH2 domain superfamily
Family
Homologous superfamily
Diseases
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Drugs
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Interactions
13 interactions
Interactor
Partner
Sources
Publications
Link
SHC2_HUMAN
ERBB2_HUMAN
BioGRID, MINT
16273093
22973453
details
SHC2_HUMAN
EGFR_HUMAN
BioGRID, MINT
16273093
22973453
24430869
8610109
details
SHC2_HUMAN
KIT_HUMAN
BioGRID, IntAct
24728074
details
SHC2_HUMAN
MET_HUMAN
BioGRID, IntAct
24728074
details
SHC2_HUMAN
VGFR2_HUMAN
BioGRID, HPRD
10749680
12214271
9790910
details
SHC2_HUMAN
VGFR1_HUMAN
BioGRID
10749680
9790910
details
SHC2_HUMAN
ERBB3_HUMAN
BioGRID
22973453
details
SHC2_HUMAN
ERBB4_HUMAN
BioGRID
22973453
details
SHC2_HUMAN
NTRK3_HUMAN
HPRD
12006576
details
SHC2_HUMAN
NTRK1_HUMAN
HPRD
12006576
9507002
details
SHC2_HUMAN
RHG32_HUMAN
BioGRID
12446789
details
SHC2_HUMAN
GRB2_HUMAN
BioGRID, HPRD
12006576
24430869
details
SHC2_HUMAN
NTRK2_HUMAN
HPRD
12006576
9507002
details
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