Entity Details

Primary name LGUL_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ04760
EntryNameLGUL_HUMAN
FullNameLactoylglutathione lyase
TaxID9606
Evidenceevidence at protein level
Length184
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesGLO1

GO terms

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GOName
GO:0004462 lactoylglutathione lyase activity
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005975 carbohydrate metabolic process
GO:0006090 pyruvate metabolic process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006749 glutathione metabolic process
GO:0008270 zinc ion binding
GO:0009438 methylglyoxal metabolic process
GO:0030316 osteoclast differentiation
GO:0043066 negative regulation of apoptotic process
GO:0070062 extracellular exosome

Subcellular Location

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Domains

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DomainNameCategoryType
IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domainDomainDomain
IPR004361 Glyoxalase IFamilyFamily
IPR018146 Glyoxalase I, conserved siteSiteConserved site
IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenaseFamilyHomologous superfamily
IPR037523 Vicinal oxygen chelate (VOC) domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00143 GlutathioneDrugbanksmall molecule
DB00328 IndomethacinDrugbanksmall molecule
DB03130 S-P-NitrobenzyloxycarbonylglutathioneDrugbanksmall molecule
DB03330 S-(N-hydroxy-N-iodophenylcarbamoyl)glutathioneDrugbanksmall molecule
DB03345 MercaptoethanolDrugbanksmall molecule
DB03602 S-benzylglutathioneDrugbanksmall molecule
DB04132 S-HexylglutathioneDrugbanksmall molecule
DB08179 methyl 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoateDrugbanksmall molecule