Entity Details

Primary name CACB2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ08289
EntryNameCACB2_HUMAN
FullNameVoltage-dependent L-type calcium channel subunit beta-2
TaxID9606
Evidenceevidence at protein level
Length660
SequenceStatuscomplete
DateCreated1994-10-01
DateModified2021-06-02

Ontological Relatives

GenesCACNB2

GO terms

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GOName
GO:0005245 voltage-gated calcium channel activity
GO:0005262 calcium channel activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0007268 chemical synaptic transmission
GO:0007528 neuromuscular junction development
GO:0007601 visual perception
GO:0051015 actin filament binding
GO:0051928 positive regulation of calcium ion transport
GO:0061337 cardiac conduction
GO:0070509 calcium ion import
GO:0072659 protein localization to plasma membrane
GO:0086045 membrane depolarization during AV node cell action potential
GO:0086091 regulation of heart rate by cardiac conduction
GO:0098684 photoreceptor ribbon synapse
GO:0098793 presynapse
GO:0098912 membrane depolarization during atrial cardiac muscle cell action potential
GO:0099635 voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels
GO:1901385 regulation of voltage-gated calcium channel activity
GO:1901843 positive regulation of high voltage-gated calcium channel activity
GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
GO:1990454 L-type voltage-gated calcium channel complex

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000584 Voltage-dependent calcium channel, L-type, beta subunitFamilyFamily
IPR001452 SH3 domainDomainDomain
IPR005444 Voltage-dependent calcium channel, L-type, beta-2 subunitFamilyFamily
IPR008145 Guanylate kinase/L-type calcium channel beta subunitDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR035605 CACNB2, SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00153 ErgocalciferolDrugbanksmall molecule
DB00228 EnfluraneDrugbanksmall molecule
DB00243 RanolazineDrugbanksmall molecule
DB00252 PhenytoinDrugbanksmall molecule
DB00270 IsradipineDrugbanksmall molecule
DB00273 TopiramateDrugbanksmall molecule
DB00393 NimodipineDrugbanksmall molecule
DB00401 NisoldipineDrugbanksmall molecule
DB00421 SpironolactoneDrugbanksmall molecule
DB00622 NicardipineDrugbanksmall molecule
DB00653 Magnesium sulfateDrugbanksmall molecule
DB00825 LevomentholDrugbanksmall molecule
DB01023 FelodipineDrugbanksmall molecule
DB01054 NitrendipineDrugbanksmall molecule
DB01110 MiconazoleDrugbanksmall molecule
DB01115 NifedipineDrugbanksmall molecule
DB01118 AmiodaroneDrugbanksmall molecule
DB01388 MibefradilDrugbanksmall molecule
DB04855 DronedaroneDrugbanksmall molecule
DB06712 NilvadipineDrugbanksmall molecule
DB09089 TrimebutineDrugbanksmall molecule
DB09231 BenidipineDrugbanksmall molecule
DB09232 CilnidipineDrugbanksmall molecule
DB09236 LacidipineDrugbanksmall molecule
DB09238 ManidipineDrugbanksmall molecule
DB11093 Calcium citrateDrugbanksmall molecule
DB11148 ButambenDrugbanksmall molecule
DB11348 Calcium PhosphateDrugbanksmall molecule
DB13746 BioallethrinDrugbanksmall molecule
DB13961 Fish oilDrugbankbiotech
DB14481 Calcium phosphate dihydrateDrugbanksmall molecule