Entity Details

Primary name ADCY1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ08828
EntryNameADCY1_HUMAN
FullNameAdenylate cyclase type 1
TaxID9606
Evidenceevidence at protein level
Length1119
SequenceStatuscomplete
DateCreated1994-10-01
DateModified2021-06-02

Ontological Relatives

GenesADCY1

GO terms

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GOName
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0003091 renal water homeostasis
GO:0004016 adenylate cyclase activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006171 cAMP biosynthetic process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007409 axonogenesis
GO:0007420 brain development
GO:0007616 long-term memory
GO:0007623 circadian rhythm
GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity
GO:0010226 response to lithium ion
GO:0019933 cAMP-mediated signaling
GO:0032793 positive regulation of CREB transcription factor activity
GO:0034199 activation of protein kinase A activity
GO:0042493 response to drug
GO:0042752 regulation of circadian rhythm
GO:0045121 membrane raft
GO:0046872 metal ion binding
GO:0070062 extracellular exosome
GO:0071277 cellular response to calcium ion
GO:0071377 cellular response to glucagon stimulus
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098686 hippocampal mossy fiber to CA3 synapse
GO:0098978 glutamatergic synapse
GO:0099061 integral component of postsynaptic density membrane
GO:0150076 neuroinflammatory response
GO:1900273 positive regulation of long-term synaptic potentiation
GO:1904322 cellular response to forskolin
GO:2000300 regulation of synaptic vesicle exocytosis

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Membrane
Membrane raft

Domains

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DomainNameCategoryType
IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclaseDomainDomain
IPR018297 Adenylyl cyclase class-4/guanylyl cyclase, conserved siteSiteConserved site
IPR029787 Nucleotide cyclaseFamilyHomologous superfamily
IPR030672 Adenylate cyclaseFamilyFamily
IPR032628 Adenylate cyclase, N-terminalDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00131 Adenosine phosphateDrugbanksmall molecule
DB00171 ATPDrugbanksmall molecule
DB09121 AurothioglucoseDrugbanksmall molecule
DB13749 Magnesium gluconateSwissprotsmall molecule

Interactions

4 interactions