Entity Details

Primary name NMDE1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ12879
EntryNameNMDE1_HUMAN
FullNameGlutamate receptor ionotropic, NMDA 2A
TaxID9606
Evidenceevidence at protein level
Length1464
SequenceStatuscomplete
DateCreated2001-06-01
DateModified2021-06-02

Ontological Relatives

GenesGRIN2A

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0001964 startle response
GO:0001975 response to amphetamine
GO:0004972 NMDA glutamate receptor activity
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007215 glutamate receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007420 brain development
GO:0007611 learning or memory
GO:0007613 memory
GO:0008021 synaptic vesicle
GO:0008270 zinc ion binding
GO:0008542 visual learning
GO:0009611 response to wounding
GO:0009986 cell surface
GO:0014069 postsynaptic density
GO:0015276 ligand-gated ion channel activity
GO:0017146 NMDA selective glutamate receptor complex
GO:0019233 sensory perception of pain
GO:0022008 neurogenesis
GO:0022849 glutamate-gated calcium ion channel activity
GO:0030431 sleep
GO:0030659 cytoplasmic vesicle membrane
GO:0033058 directional locomotion
GO:0038023 signaling receptor activity
GO:0042177 negative regulation of protein catabolic process
GO:0042417 dopamine metabolic process
GO:0042428 serotonin metabolic process
GO:0042493 response to drug
GO:0042734 presynaptic membrane
GO:0043065 positive regulation of apoptotic process
GO:0043197 dendritic spine
GO:0045471 response to ethanol
GO:0048167 regulation of synaptic plasticity
GO:0060079 excitatory postsynaptic potential
GO:0060291 long-term synaptic potentiation
GO:0097060 synaptic membrane
GO:0097202 activation of cysteine-type endopeptidase activity
GO:0097553 calcium ion transmembrane import into cytosol
GO:0098839 postsynaptic density membrane
GO:0098976 excitatory chemical synaptic transmission
GO:0098978 glutamatergic synapse
GO:0099061 integral component of postsynaptic density membrane
GO:1903539 protein localization to postsynaptic membrane
GO:2000310 regulation of NMDA receptor activity

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasmic vesicle membrane

Domains

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DomainNameCategoryType
IPR001320 Ionotropic glutamate receptorDomainDomain
IPR001508 Ionotropic glutamate receptor, metazoaFamilyFamily
IPR001828 Receptor, ligand binding regionDomainDomain
IPR018884 Glutamate [NMDA] receptor, epsilon subunit, C-terminalDomainDomain
IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domainDomainDomain
IPR028082 Periplasmic binding protein-like IFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00142 Glutamic acidDrugbanksmall molecule
DB00145 GlycineDrugbanksmall molecule
DB00193 TramadolDrugbanksmall molecule
DB00228 EnfluraneDrugbanksmall molecule
DB00289 AtomoxetineDrugbanksmall molecule
DB00312 PentobarbitalDrugbanksmall molecule
DB00333 MethadoneDrugbanksmall molecule
DB00418 SecobarbitalDrugbanksmall molecule
DB00454 MeperidineDrugbanksmall molecule
DB00659 AcamprosateDrugbanksmall molecule
DB00843 DonepezilDrugbanksmall molecule
DB00874 GuaifenesinDrugbanksmall molecule
DB00949 FelbamateDrugbanksmall molecule
DB01043 MemantineDrugbanksmall molecule
DB01159 HalothaneDrugbanksmall molecule
DB01174 PhenobarbitalDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01520 TenocyclidineDrugbanksmall molecule
DB01708 PrasteroneDrugbanksmall molecule
DB04896 MilnacipranDrugbanksmall molecule
DB06151 AcetylcysteineDrugbanksmall molecule
DB06738 KetobemidoneDrugbanksmall molecule
DB06741 GavestinelDrugbanksmall molecule
DB09409 Magnesium acetate tetrahydrateDrugbanksmall molecule
DB09481 Magnesium carbonateDrugbanksmall molecule
DB11823 EsketamineDrugbanksmall molecule
DB13146 Fluciclovine (18F)Drugbanksmall molecule

Interactions

39 interactions

InteractorPartnerSourcesPublicationsLink
NMDE1_HUMANDLG4_HUMANBioGRID, DIP, HPRD, MINT10336672 10648730 11222640 11937501 12419528 14732708 16332682 16990796 17360663 17459877 18400955 20869595 21653829 22375001 23183381 7569905 8601796 9278515 9286858 details
NMDE1_HUMANAKT1_HUMANBioGRID, MINT25640309 details
NMDE1_HUMANDLG1_HUMANBioGRID, HPRD10336672 12933808 8601796 details
NMDE1_HUMANSRC_HUMANBioGRID, HPRD10195142 10458595 10846184 10884433 12932824 details
NMDE1_HUMANFYN_HUMANBioGRID, HPRD10458595 12419528 12932824 9892651 details
NMDE1_HUMANDLG3_HUMANBioGRID, HPRD11937501 12070168 9278515 details
NMDE1_HUMANDLG2_HUMANBioGRID, HPRD10648730 12890763 9278515 details
NMDE1_HUMANNMDZ1_HUMANBioGRID, HPRD10862698 11803122 12068077 12191494 12391275 12893641 14602821 14732708 15888440 17459877 18233995 19811606 22375001 23621516 8139656 9721050 details
NMDE1_HUMANSPTN1_HUMANBioGRID9670010 details
NMDE1_HUMANNEDD4_HUMANBioGRID23639431 details
NMDE1_HUMANNMDE1_HUMANBioGRID, HPRD11222640 15888440 details
NMDE1_HUMANNMDE2_HUMANBioGRID15888440 details
NMDE1_HUMANCSK22_HUMANBioGRID20869595 details
NMDE1_HUMANCSK21_HUMANBioGRID20869595 details
NMDE1_HUMANCSK2B_HUMANBioGRID20869595 details
NMDE1_HUMANAP1M1_HUMANBioGRID, HPRD15254094 details
NMDE1_HUMANAP2M1_HUMANBioGRID15254094 details
NMDE1_HUMANAP4M1_HUMANHPRD15254094 details
NMDE1_HUMANIL16_HUMANHPRD10479680 details
NMDE1_HUMANLRP1_HUMANDIP17360663 details
NMDE1_HUMANNOS1_HUMANDIP17360663 details
NMDE1_HUMANFAK2_HUMANBioGRID, HPRD11478920 12576483 details
NMDE1_HUMANNMD3B_HUMANBioGRID12008020 14602821 details
NMDE1_HUMANPTN4_HUMANBioGRID, HPRD10748123 22000519 details
NMDE1_HUMANDLGP1_HUMANBioGRID, HPRD9286858 details
NMDE1_HUMANAPLP1_HUMANBioGRID25683482 details
NMDE1_HUMANAPLP2_HUMANBioGRID25683482 details
NMDE1_HUMANA4_HUMANBioGRID19811606 23621516 details
NMDE1_HUMANNETO1_HUMANBioGRID23621516 details
NMDE1_HUMANEAA3_HUMANBioGRID17459877 details
NMDE1_HUMANACTN1_HUMANHPRD11854440 details
NMDE1_HUMANCDK5_HUMANHPRD11675505 details
NMDE1_HUMANRGS3_HUMANHPRD16637659 details
NMDE1_HUMANCSKP_HUMANHPRD16637659 details
NMDE1_HUMANKPCA_HUMANHPRD11104776 details
NMDE1_HUMANNMD3A_HUMANHPRD12391275 details
NMDE1_HUMANKCC2B_HUMANHPRD12147342 details
NMDE1_HUMANRHG32_HUMANHPRD12531901 details
NMDE1_HUMANPLCG1_HUMANHPRD9231720 details