Entity Details

Primary name TRI32_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13049
EntryNameTRI32_HUMAN
FullNameE3 ubiquitin-protein ligase TRIM32
TaxID9606
Evidenceevidence at protein level
Length653
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesTRIM32

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0001894 tissue homeostasis
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005863 striated muscle myosin thick filament
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007014 actin ubiquitination
GO:0008270 zinc ion binding
GO:0009411 response to UV
GO:0016567 protein ubiquitination
GO:0017022 myosin binding
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030957 Tat protein binding
GO:0031369 translation initiation factor binding
GO:0032479 regulation of type I interferon production
GO:0032897 negative regulation of viral transcription
GO:0034612 response to tumor necrosis factor
GO:0042802 identical protein binding
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043130 ubiquitin binding
GO:0043621 protein self-association
GO:0045087 innate immune response
GO:0045444 fat cell differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045732 positive regulation of protein catabolic process
GO:0045787 positive regulation of cell cycle
GO:0045862 positive regulation of proteolysis
GO:0046716 muscle cell cellular homeostasis
GO:0048147 negative regulation of fibroblast proliferation
GO:0050769 positive regulation of neurogenesis
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051155 positive regulation of striated muscle cell differentiation
GO:0061564 axon development
GO:0061630 ubiquitin protein ligase activity
GO:0070936 protein K48-linked ubiquitination
GO:1902187 negative regulation of viral release from host cell
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway
GO:1903883 positive regulation of interleukin-17-mediated signaling pathway
GO:1903886 positive regulation of chemokine (C-C motif) ligand 20 production
GO:2000147 positive regulation of cell motility

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000315 B-box-type zinc fingerDomainDomain
IPR001258 NHL repeatRepeatRepeat
IPR001841 Zinc finger, RING-typeDomainDomain
IPR011042 Six-bladed beta-propeller, TolB-likeFamilyHomologous superfamily
IPR013017 NHL repeat, subgroupRepeatRepeat
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site
IPR027370 RING-type zinc-finger, LisH dimerisation motifDomainDomain

Diseases

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Disease IDSourceNameDescription
615988 OMIMBardet-Biedl syndrome 11 (BBS11)A syndrome characterized by usually severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Bardet-Biedl syndrome inheritance is autosomal recessive, but three mutated alleles (two at one locus, and a third at a second locus) may be required for clinical manifestation of some forms of the disease. The disease is caused by variants affecting the gene represented in this entry. It has been suggested that TRIM32 might be the E3 ubiquitin ligase for BBS2, a component of the BBSome complex involved in ciliogenesis, that is ubiquitinated and degraded by the proteasome (PubMed:22500027).
254110 OMIMMuscular dystrophy, limb-girdle, autosomal recessive 8 (LGMDR8)An autosomal recessive degenerative myopathy characterized by pelvic girdle, shoulder girdle and quadriceps muscle weakness. Clinical phenotype and severity are highly variable. Disease progression is slow and most patients remain ambulatory into the sixth decade of life. The disease is caused by variants affecting the gene represented in this entry.

Interactions

92 interactions

InteractorPartnerSourcesPublicationsLink
TRI32_HUMANPDE9A_HUMANBioGRID, HPRD, IntAct16189514 19060904 25416956 25910212 26871637 31515488 32296183 details
TRI32_HUMANUBQL1_HUMANBioGRID, HPRD, IntAct16189514 25416956 32296183 details
TRI32_HUMANUBQL4_HUMANBioGRID, HPRD, IntAct16713569 details
TRI32_HUMANATX1_HUMANBioGRID, HPRD, IntAct16713569 32814053 details
TRI32_HUMANUBE2N_HUMANBioGRID, IntAct17994549 19549727 19690564 21143188 27173435 31123703 unassigned1312 details
TRI32_HUMANUB2V1_HUMANBioGRID, IntAct19549727 21143188 32296183 details
TRI32_HUMANUBE2U_HUMANBioGRID, IntAct19549727 25416956 details
TRI32_HUMANUTER_HUMANBioGRID, IntAct, MINT21516116 25416956 31515488 32296183 details
TRI32_HUMANTRI32_HUMANBioGRID, HPRD, IntAct11331580 16816390 17994549 19349376 21628460 22493164 23444366 25416956 30884854 32296183 details
TRI32_HUMANTRI27_HUMANBioGRID, IntAct11331580 22493164 details
TRI32_HUMANVPS11_HUMANBioGRID, IntAct22493164 details
TRI32_HUMANRNF41_HUMANBioGRID, IntAct22493164 details
TRI32_HUMANRN208_HUMANBioGRID, IntAct22493164 details
TRI32_HUMANTRIM5_HUMANBioGRID, IntAct22493164 details
TRI32_HUMANAKTIP_HUMANBioGRID, IntAct23414517 26186194 28514442 details
TRI32_HUMANSDCB1_HUMANBioGRID, IntAct25416956 31515488 32296183 details
TRI32_HUMANPTN11_HUMANBioGRID, IntAct25416956 27229929 31515488 details
TRI32_HUMANABI2_HUMANBioGRID, HPRD, IntAct18632609 25416956 25910212 28514442 29892012 31515488 32296183 details
TRI32_HUMANPRAF1_HUMANBioGRID, IntAct25416956 25910212 32296183 details
TRI32_HUMANSYT6_HUMANBioGRID, IntAct25416956 32296183 details
TRI32_HUMANKCTD9_HUMANBioGRID, IntAct25416956 32296183 details
TRI32_HUMANCLIP4_HUMANBioGRID, IntAct25416956 32296183 details
TRI32_HUMANIQCB1_HUMANBioGRID, UniProt25552655 28498859 details
TRI32_HUMANICMT_HUMANBioGRID, IntAct32296183 details
TRI32_HUMANUBQL2_HUMANBioGRID, IntAct32296183 details
TRI32_HUMANTEANC_HUMANBioGRID, IntAct32296183 details
TRI32_HUMANPTCD2_HUMANBioGRID, IntAct25416956 32296183 details
TRI32_HUMANPELI2_HUMANBioGRID, IntAct32296183 details
TRI32_HUMANNTAQ1_HUMANBioGRID, IntAct32296183 details
TRI32_HUMANGEM_HUMANBioGRID, IntAct32296183 details
TRI32_HUMANFADS6_HUMANBioGRID, IntAct32296183 details
TRI32_HUMANERGI3_HUMANBioGRID, IntAct32296183 details
TRI32_HUMANG137B_HUMANBioGRID, IntAct32296183 details
TRI32_HUMANDERL1_HUMANBioGRID, IntAct32296183 details
TRI32_HUMANNGAL_HUMANBioGRID, IntAct32296183 details
TRI32_HUMANMOB1A_HUMANBioGRID, IntAct32296183 details
TRI32_HUMANRAB7L_HUMANBioGRID, IntAct32296183 details
TRI32_HUMANTTC23_HUMANBioGRID, IntAct32296183 details
TRI32_HUMANDTBP1_HUMANBioGRID, IntAct19349376 26186194 28514442 details
TRI32_HUMANTRIM1_HUMANBioGRID11331580 details
TRI32_HUMANTRI23_HUMANBioGRID11331580 details
TRI32_HUMANPIAS3_HUMANBioGRID17987106 details
TRI32_HUMANPIAS4_HUMANBioGRID16816390 details
TRI32_HUMANIRAK1_HUMANBioGRID21903422 details
TRI32_HUMANXIAP_HUMANBioGRID21628460 details
TRI32_HUMANUB2E2_HUMANBioGRID21143188 31028095 details
TRI32_HUMANUB2E1_HUMANBioGRID16816390 19349376 21143188 31028095 details
TRI32_HUMANUB2E3_HUMANBioGRID21143188 details
TRI32_HUMANUB2V2_HUMANBioGRID21143188 details
TRI32_HUMANUB2D1_HUMANBioGRID16816390 21143188 22745133 23408431 25701873 details
TRI32_HUMANUB2D2_HUMANBioGRID21143188 23408431 25701873 details
TRI32_HUMANUB2D3_HUMANBioGRID21143188 22745133 23408431 25701873 details
TRI32_HUMANSTING_HUMANBioGRID22745133 details
TRI32_HUMANTOP1_HUMANBioGRID12549820 details
TRI32_HUMANUBC_HUMANBioGRID23408431 28190767 details
TRI32_HUMANGLIS2_HUMANBioGRID24500717 details
TRI32_HUMANMYCN_HUMANBioGRID25100564 details
TRI32_HUMANNDRG2_HUMANBioGRID25701873 details
TRI32_HUMANTRI72_HUMANBioGRID25701873 details
TRI32_HUMANHSP74_HUMANBioGRID28052117 details
TRI32_HUMANMLP3A_HUMANBioGRID31685529 details
TRI32_HUMANMLP3C_HUMANBioGRID31685529 details
TRI32_HUMANGBRAP_HUMANBioGRID31685529 details
TRI32_HUMANGBRL1_HUMANBioGRID31685529 details
TRI32_HUMANMLP3B_HUMANBioGRID31685529 details
TRI32_HUMANGBRL2_HUMANBioGRID31685529 details
TRI32_HUMANSQSTM_HUMANBioGRID31685529 details
TRI32_HUMAN1433S_HUMANBioGRID, MINT15778465 23444366 details
TRI32_HUMANHS90B_HUMANIntAct22939624 details
TRI32_HUMAN1433B_HUMANBioGRID, IntAct23444366 24255178 details
TRI32_HUMANEXOC1_HUMANBioGRID, IntAct27173435 28514442 unassigned1312 details
TRI32_HUMANS23IP_HUMANBioGRID, IntAct27173435 28514442 unassigned1312 details
TRI32_HUMANTP4AP_HUMANBioGRID, IntAct27173435 unassigned1312 details
TRI32_HUMANEXOC3_HUMANBioGRID, IntAct27173435 unassigned1312 details
TRI32_HUMANCASS4_HUMANIntAct31413325 details
TRI32_HUMANBIRC2_HUMANBioGRID21628460 details
TRI32_HUMANBIRC3_HUMANBioGRID21628460 details
TRI32_HUMANRARA_HUMANBioGRID21984809 details
TRI32_HUMANRXRA_HUMANBioGRID21984809 details
TRI32_HUMANDDX58_HUMANBioGRID22745133 details
TRI32_HUMANHS90A_HUMANBioGRID22939624 details
TRI32_HUMAN1433T_HUMANBioGRID23444366 details
TRI32_HUMAN1433F_HUMANBioGRID23444366 28052117 details
TRI32_HUMAN1433G_HUMANBioGRID23444366 details
TRI32_HUMAN1433E_HUMANBioGRID23444366 details
TRI32_HUMAN1433Z_HUMANBioGRID23444366 details
TRI32_HUMANP73_HUMANBioGRID23828567 details
TRI32_HUMANP53_HUMANBioGRID25146927 details
TRI32_HUMANAMRA1_HUMANBioGRID31123703 details
TRI32_HUMANULK1_HUMANBioGRID31123703 details
TRI32_HUMANOTUL_HUMANBioGRID31504727 details
TRI32_HUMANTRAF2_HUMANBioGRID32145086 details