Entity Details

Primary name REST_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13127
EntryNameREST_HUMAN
FullNameRE1-silencing transcription factor
TaxID9606
Evidenceevidence at protein level
Length1097
SequenceStatuscomplete
DateCreated2006-12-12
DateModified2021-06-02

Ontological Relatives

GenesREST

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001666 response to hypoxia
GO:0002931 response to ischemia
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0008134 transcription factor binding
GO:0008285 negative regulation of cell population proliferation
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0017053 transcription repressor complex
GO:0032348 negative regulation of aldosterone biosynthetic process
GO:0035019 somatic stem cell population maintenance
GO:0035690 cellular response to drug
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043922 negative regulation by host of viral transcription
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045667 regulation of osteoblast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045955 negative regulation of calcium ion-dependent exocytosis
GO:0046676 negative regulation of insulin secretion
GO:0046872 metal ion binding
GO:0050768 negative regulation of neurogenesis
GO:0050885 neuromuscular process controlling balance
GO:0050910 detection of mechanical stimulus involved in sensory perception of sound
GO:0060088 auditory receptor cell stereocilium organization
GO:0060379 cardiac muscle cell myoblast differentiation
GO:0070933 histone H4 deacetylation
GO:0071257 cellular response to electrical stimulus
GO:0071385 cellular response to glucocorticoid stimulus
GO:0097150 neuronal stem cell population maintenance
GO:0099563 modification of synaptic structure
GO:1902459 positive regulation of stem cell population maintenance
GO:1903203 regulation of oxidative stress-induced neuron death
GO:1903204 negative regulation of oxidative stress-induced neuron death
GO:1903223 positive regulation of oxidative stress-induced neuron death
GO:2000065 negative regulation of cortisol biosynthetic process
GO:2000678 negative regulation of transcription regulatory region DNA binding
GO:2000706 negative regulation of dense core granule biogenesis
GO:2000740 negative regulation of mesenchymal stem cell differentiation
GO:2000798 negative regulation of amniotic stem cell differentiation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR013087 Zinc finger C2H2-typeDomainDomain
IPR027757 RE1-silencing transcription factorFamilyFamily
IPR036236 Zinc finger C2H2 superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
617626 OMIMFibromatosis, gingival, 5 (GINGF5)An autosomal dominant form of hereditary gingival fibromatosis, a rare condition characterized by a slow, progressive overgrowth of the gingiva. The excess gingival tissue can cover part of or the entire crown, and can result in diastemas, teeth displacement, or retention of primary or impacted teeth. The disease is caused by variants affecting the gene represented in this entry.
612431 OMIMDeafness, autosomal dominant, 27 (DFNA27)A form of non-syndromic deafness characterized by postlingual, progressive, moderate to profound sensorineural hearing loss. The disease may be caused by variants affecting the gene represented in this entry. An intronic variant that affects alternative splicing of REST and inactivation of REST repressor activity fully segregates with deafness in a 3-generation family.
616806 OMIMWilms tumor 6 (WT6)A pediatric malignancy of kidney, and the most common childhood abdominal malignancy. It is caused by the uncontrolled multiplication of renal stem, stromal, and epithelial cells. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

43 interactions

InteractorPartnerSourcesPublicationsLink
REST_HUMANRCOR1_HUMANBioGRID, DIP, HPRD10449787 15897453 17939992 25197063 details
REST_HUMANFBW1A_HUMANBioGRID, DIP18354482 18354483 24760862 25197063 25299066 25453754 25515538 33038663 details
REST_HUMANHDAC1_HUMANBioGRID10491605 18806873 details
REST_HUMANCDYL_HUMANBioGRID19061646 details
REST_HUMANTBP_HUMANBioGRID15197246 details
REST_HUMANTF2B_HUMANBioGRID15197246 details
REST_HUMANSIN3B_HUMANBioGRID, HPRD10570134 15197246 details
REST_HUMANTCP4_HUMANBioGRID20080105 details
REST_HUMANPLK1_HUMANBioGRID25453754 details
REST_HUMANMK01_HUMANBioGRID25197063 details
REST_HUMANAURKA_HUMANBioGRID28218735 details
REST_HUMANSMCE1_HUMANBioGRID, IntAct12192000 details
REST_HUMANSMCA4_HUMANBioGRID, IntAct12192000 17023429 details
REST_HUMANSMRC2_HUMANBioGRID, IntAct12192000 details
REST_HUMANKDM5C_HUMANBioGRID, DIP17468742 details
REST_HUMANEHMT2_HUMANBioGRID, DIP15200951 17468742 details
REST_HUMANFBW1B_HUMANBioGRID, DIP18354482 18354483 22017875 24500709 25332235 25515538 25900982 details
REST_HUMANHDAC5_HUMANBioGRID17011572 27976729 details
REST_HUMANHDAC4_HUMANBioGRID17011572 details
REST_HUMANSP1_HUMANBioGRID15528196 details
REST_HUMANSIN3A_HUMANBioGRID10491605 21693630 details
REST_HUMANGRIA2_HUMANBioGRID21948504 details
REST_HUMANTERF2_HUMANBioGRID18818083 details
REST_HUMANFBXW2_HUMANBioGRID18354482 details
REST_HUMANFBXW4_HUMANBioGRID18354482 details
REST_HUMANFBXW5_HUMANBioGRID18354482 details
REST_HUMANFBXW8_HUMANBioGRID18354482 details
REST_HUMANFBXW7_HUMANBioGRID18354482 details
REST_HUMANKC1E_HUMANBioGRID24760862 details
REST_HUMANUBC_HUMANBioGRID18818083 details
REST_HUMANTEX14_HUMANBioGRID25453754 details
REST_HUMANSCYL1_HUMANBioGRID25453754 details
REST_HUMANPIN1_HUMANBioGRID25197063 details
REST_HUMANCTDS1_HUMANBioGRID25197063 details
REST_HUMANFOXK2_HUMANBioGRID27773593 details
REST_HUMANMDM2_HUMANBioGRID27004407 details
REST_HUMANTHOC4_HUMANBioGRID27976729 details
REST_HUMANNUCL_HUMANBioGRID27976729 details
REST_HUMANHNRPQ_HUMANBioGRID27976729 details
REST_HUMANNPM_HUMANBioGRID27976729 details
REST_HUMANPARP1_HUMANBioGRID27976729 details
REST_HUMANTIF1B_HUMANBioGRID27976729 details
REST_HUMANHD_HUMANHPRD12881722 details