Entity Details

Primary name FADD_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13158
EntryNameFADD_HUMAN
FullNameFAS-associated death domain protein
TaxID9606
Evidenceevidence at protein level
Length208
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesFADD

GO terms

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GOName
GO:0001822 kidney development
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0002020 protease binding
GO:0002821 positive regulation of adaptive immune response
GO:0005123 death receptor binding
GO:0005164 tumor necrosis factor receptor binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007166 cell surface receptor signaling pathway
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0016032 viral process
GO:0031264 death-inducing signaling complex
GO:0031265 CD95 death-inducing signaling complex
GO:0032729 positive regulation of interferon-gamma production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032813 tumor necrosis factor receptor superfamily binding
GO:0033077 T cell differentiation in thymus
GO:0033612 receptor serine/threonine kinase binding
GO:0034138 toll-like receptor 3 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0035877 death effector domain binding
GO:0036462 TRAIL-activated apoptotic signaling pathway
GO:0042104 positive regulation of activated T cell proliferation
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0043029 T cell homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043278 response to morphine
GO:0044297 cell body
GO:0044877 protein-containing complex binding
GO:0045087 innate immune response
GO:0045121 membrane raft
GO:0045651 positive regulation of macrophage differentiation
GO:0045862 positive regulation of proteolysis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048148 behavioral response to cocaine
GO:0048535 lymph node development
GO:0048536 spleen development
GO:0048538 thymus development
GO:0051607 defense response to virus
GO:0060340 positive regulation of type I interferon-mediated signaling pathway
GO:0060546 negative regulation of necroptotic process
GO:0070236 negative regulation of activation-induced cell death of T cells
GO:0071260 cellular response to mechanical stimulus
GO:0071550 death-inducing signaling complex assembly
GO:0089720 caspase binding
GO:0097049 motor neuron apoptotic process
GO:0097190 apoptotic signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097202 activation of cysteine-type endopeptidase activity
GO:0097342 ripoptosome
GO:0097527 necroptotic signaling pathway
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000454 positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000488 Death domainDomainDomain
IPR001875 Death effector domainDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR016729 FADDFamilyFamily

Diseases

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Interactions

83 interactions

InteractorPartnerSourcesPublicationsLink
FADD_HUMANCASPA_HUMANBioGRID, HPRD, MINT, UniProt11717445 15069192 15659383 20829884 9045686 9228018 details
FADD_HUMANTNR6_HUMANBioGRID, DIP, HPRD, IntAct, MINT10545115 11035039 11717445 12107169 15659383 16498403 16554480 17159907 18328427 19118384 19483105 20876301 20935634 21382479 21625644 21713032 21803845 22864571 25241761 26186194 26942442 27321185 28514442 29795330 7536190 7538907 8967952 9082980 9325248 9990010 details
FADD_HUMANCASP8_HUMANBioGRID, DIP, HPIDb, HPRD, IntAct, MINT11717445 12107169 12702723 12887920 12911633 14612908 15280356 15659383 17047155 17159907 17290218 18485876 19060883 19176810 19524512 20103630 20448643 20829884 21458669 21525013 21620750 21737329 21737330 21785459 21988832 22173242 22179575 22274400 22864571 23142077 23429285 23955153 23972990 24098568 25043603 25911380 25939870 26437781 26972597 27321185 27552911 27560715 29497034 29795330 30561431 31046799 8681376 9228018 9343261 details
FADD_HUMANFADD_HUMANBioGRID, IntAct25502805 27321185 30561431 31515488 32296183 7536190 8681376 details
FADD_HUMANXPO5_HUMANHPRD, IntAct12702765 details
FADD_HUMANMBD4_HUMANBioGRID, HPRD, IntAct12702765 details
FADD_HUMANMYD88_HUMANBioGRID, HPRD, IntAct10880445 11828002 21988832 details
FADD_HUMANPHOCN_HUMANBioGRID, HPRD, IntAct16169070 details
FADD_HUMANDDX24_HUMANHPRD, IntAct16169070 details
FADD_HUMANLRCC1_HUMANHPRD, IntAct16169070 details
FADD_HUMANTRADD_HUMANBioGRID, DIP, HPRD, IntAct10911999 11112409 12107169 12796506 12911633 16919273 21724995 23955153 24686082 30561431 32296183 8565075 8681376 details
FADD_HUMANRIPK1_HUMANBioGRID, HPRD, IntAct11002422 11854271 19373245 19524513 21052097 21183682 21458669 21525013 21620750 21737329 22848449 22864571 23744296 23972990 24098568 24577083 26186194 26733177 26865630 26972597 27560715 29497034 30561431 32024820 32296183 details
FADD_HUMANPLK1_HUMANI2D20890306 details
FADD_HUMANSPOP_HUMANBioGRID, IntAct21988832 30190126 details
FADD_HUMANPARK7_HUMANBioGRID, IntAct21785459 details
FADD_HUMANCFLAR_HUMANBioGRID, HPRD, IntAct17047155 20829884 21737330 22322857 26972597 27321185 29497034 9208847 9228018 9326610 details
FADD_HUMANTAB1_HUMANBioGRID, MINT21900206 details
FADD_HUMANTCEA2_HUMANBioGRID, IntAct32296183 details
FADD_HUMANRNF4_HUMANBioGRID, IntAct32296183 details
FADD_HUMANZMYM5_HUMANBioGRID, IntAct32296183 details
FADD_HUMANZCH12_HUMANBioGRID, IntAct32296183 details
FADD_HUMANBTG1_HUMANBioGRID, IntAct32296183 details
FADD_HUMANSDCB1_HUMANBioGRID, IntAct32296183 details
FADD_HUMANDDT4L_HUMANBioGRID, IntAct32296183 details
FADD_HUMANABCA1_HUMANBioGRID, HPRD12235128 details
FADD_HUMANNACA_HUMANBioGRID, HPRD12684039 24901053 details
FADD_HUMANNACAM_HUMANBioGRID12684039 24901053 details
FADD_HUMANRT29_HUMANBioGRID, HPRD11376335 11753396 details
FADD_HUMANPEA15_HUMANBioGRID, HPRD10442631 10493725 details
FADD_HUMANDEDD_HUMANBioGRID, HPRD11741985 9774341 details
FADD_HUMANRO52_HUMANBioGRID21183682 details
FADD_HUMANFAF1_HUMANBioGRID, HPRD12702723 details
FADD_HUMANMKRN1_HUMANBioGRID22864571 details
FADD_HUMANATG5_HUMANBioGRID15778222 details
FADD_HUMANRAP1A_HUMANBioGRID, HPRD15207703 details
FADD_HUMANPIN1_HUMANBioGRID23606538 details
FADD_HUMANCHIP_HUMANBioGRID29795330 details
FADD_HUMANUBC9_HUMANBioGRID32296183 details
FADD_HUMANNTM2F_HUMANBioGRID32296183 details
FADD_HUMANC8AP2_HUMANBioGRID, HPRD, MINT10235259 details
FADD_HUMANTNF10_HUMANBioGRID, DIP, IntAct, MINT10894160 12198154 16554480 16801533 19427028 19432816 20097879 21459798 21525171 21822306 22266862 22585859 23678861 25551360 details
FADD_HUMANTNFL6_HUMANBioGRID, DIP, HPRD, IntAct, MINT12753742 12887920 15659383 16498403 21803845 24025841 25241761 details
FADD_HUMANTNR27_HUMANHPRD, IntAct15280356 details
FADD_HUMANTR10A_HUMANBioGRID, HPRD, IntAct15280356 15388581 19427028 21785459 23142077 27321185 28514442 29274253 29795330 9430227 details
FADD_HUMANRIPK3_HUMANBioGRID, IntAct19524513 21052097 22864571 26786097 27560715 30420664 details
FADD_HUMANNEMO_HUMANBioGRID, HPRD, IntAct16227629 21458669 30561431 details
FADD_HUMANTNR1A_HUMANBioGRID, IntAct11035039 15659383 16611992 8565075 details
FADD_HUMANLRRK2_HUMANBioGRID, IntAct19176810 details
FADD_HUMANRHOA_HUMANBioGRID, IntAct15659383 25241761 details
FADD_HUMANDAPK1_HUMANBioGRID, HPRD, IntAct12911633 15048887 25241761 details
FADD_HUMANBID_HUMANBioGRID, IntAct15659383 25241761 details
FADD_HUMANEZRI_HUMANBioGRID, IntAct15659383 21183682 25241761 details
FADD_HUMANTR10B_HUMANBioGRID, HPRD, IntAct11940602 15388581 15659383 23142077 25043603 26186194 28514442 28972304 31443721 32313199 9430227 details
FADD_HUMANTNAP3_HUMANBioGRID, IntAct20448643 26437781 30561431 details
FADD_HUMANKC1A_HUMANBioGRID, HPRD, IntAct16061179 30561431 details
FADD_HUMANGDIR1_HUMANBioGRID15659383 details
FADD_HUMANMK08_HUMANBioGRID15659383 details
FADD_HUMANMOES_HUMANBioGRID15659383 details
FADD_HUMANRYBP_HUMANBioGRID, HPRD11395500 details
FADD_HUMANHIPK3_HUMANBioGRID, HPRD10640736 11034606 details
FADD_HUMANPIDD1_HUMANBioGRID, HPRD10825539 16360037 details
FADD_HUMANKPCZ_HUMANBioGRID, HPRD11739185 details
FADD_HUMANGNDS_HUMANBioGRID21525013 details
FADD_HUMANIRF7_HUMANBioGRID21183682 details
FADD_HUMANMAVS_HUMANBioGRID16127453 details
FADD_HUMANKHDR1_HUMANBioGRID21620750 details
FADD_HUMANDAXX_HUMANBioGRID17360386 details
FADD_HUMANCLIP3_HUMANBioGRID22297296 details
FADD_HUMANEDAR_HUMANBioGRID11035039 details
FADD_HUMANTRAF2_HUMANBioGRID, HPRD16227629 23142077 details
FADD_HUMANCUL3_HUMANBioGRID23142077 details
FADD_HUMANTNFA_HUMANBioGRID24980434 details
FADD_HUMANATG12_HUMANBioGRID15778222 details
FADD_HUMANTLR3_HUMANBioGRID27810922 details
FADD_HUMANNLRC4_HUMANBioGRID27974463 details
FADD_HUMANSQSTM_HUMANBioGRID26416459 details
FADD_HUMANSKP2_HUMANBioGRID32313199 details
FADD_HUMANIRAK1_HUMANHPRD11828002 details
FADD_HUMANNOL3_HUMANHPRD15383280 details
FADD_HUMANSTAT1_HUMANHPRD10848577 details
FADD_HUMANRBP1_HUMANHPRD16227629 details
FADD_HUMANANK3_HUMANHPRD14694156 details
FADD_HUMANPTN13_HUMANHPRD16498403 details