Entity Details

Primary name GRM1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13255
EntryNameGRM1_HUMAN
FullNameMetabotropic glutamate receptor 1
TaxID9606
Evidenceevidence at protein level
Length1194
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesGRM1

GO terms

Show/Hide Table
GOName
GO:0000186 obsolete activation of MAPKK activity
GO:0000187 obsolete activation of MAPK activity
GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007216 G protein-coupled glutamate receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007626 locomotory behavior
GO:0008066 glutamate receptor activity
GO:0019233 sensory perception of pain
GO:0030425 dendrite
GO:0038037 G protein-coupled receptor dimeric complex
GO:0038038 G protein-coupled receptor homodimeric complex
GO:0042802 identical protein binding
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
GO:0051930 regulation of sensory perception of pain
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0071257 cellular response to electrical stimulus
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098712 L-glutamate import across plasma membrane
GO:0098839 postsynaptic density membrane
GO:0098872 G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GO:0098978 glutamatergic synapse
GO:0099530 G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential
GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000162 GPCR, family 3, metabotropic glutamate receptorFamilyFamily
IPR000337 GPCR, family 3FamilyFamily
IPR001256 GPCR, family 3, metabotropic glutamate receptor 1FamilyFamily
IPR001828 Receptor, ligand binding regionDomainDomain
IPR011500 GPCR, family 3, nine cysteines domainDomainDomain
IPR017978 GPCR family 3, C-terminalDomainDomain
IPR017979 GPCR, family 3, conserved siteSiteConserved site
IPR019588 Metabotropic glutamate receptor, Homer-binding domainDomainDomain
IPR028082 Periplasmic binding protein-like IFamilyHomologous superfamily
IPR038550 GPCR, family 3, nine cysteines domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00142 Glutamic acidDrugbanksmall molecule
DB04256 (S)-alpha-methyl-4-carboxyphenylglycineDrugbanksmall molecule

Interactions

44 interactions

InteractorPartnerSourcesPublicationsLink
GRM1_HUMANGRM1_HUMANBioGRID, DIP, UniProt10349865 10945991 16410359 24603153 details
GRM1_HUMANOPRM_HUMANBioGRID, MINT28298427 details
GRM1_HUMANOPTN_HUMANBioGRID16091361 details
GRM1_HUMANCCND2_HUMANBioGRID28205554 details
GRM1_HUMANCD44_HUMANBioGRID28205554 details
GRM1_HUMANCDN2B_HUMANBioGRID28205554 details
GRM1_HUMANEPHA2_HUMANBioGRID28205554 details
GRM1_HUMANFGFR4_HUMANBioGRID28205554 details
GRM1_HUMANERD22_HUMANBioGRID28205554 details
GRM1_HUMANMP2K5_HUMANBioGRID28205554 details
GRM1_HUMANTTYH2_HUMANBioGRID28205554 details
GRM1_HUMANBECN1_HUMANBioGRID28205554 details
GRM1_HUMANCCNE1_HUMANBioGRID28205554 details
GRM1_HUMANCDK4_HUMANBioGRID28205554 details
GRM1_HUMANCDK6_HUMANBioGRID28205554 details
GRM1_HUMANCDN2C_HUMANBioGRID28205554 details
GRM1_HUMANERBB2_HUMANBioGRID28205554 details
GRM1_HUMANIGF1R_HUMANBioGRID28205554 details
GRM1_HUMANKAT2A_HUMANBioGRID28205554 details
GRM1_HUMANLATS2_HUMANBioGRID28205554 details
GRM1_HUMANMYC_HUMANBioGRID28205554 details
GRM1_HUMANMERL_HUMANBioGRID28205554 details
GRM1_HUMANPGFRA_HUMANBioGRID28205554 details
GRM1_HUMANRAF1_HUMANBioGRID28205554 details
GRM1_HUMANSTK11_HUMANBioGRID28205554 details
GRM1_HUMANTERT_HUMANBioGRID28205554 details
GRM1_HUMANRASF1_HUMANBioGRID28205554 details
GRM1_HUMANCABIN_HUMANBioGRID19717561 details
GRM1_HUMANE41L2_HUMANBioGRID15372499 details
GRM1_HUMANCASR_HUMANBioGRID11489900 details
GRM1_HUMANIMA5_HUMANMINT19084525 details
GRM1_HUMANIMA4_HUMANMINT19084525 details
GRM1_HUMANTRPC1_HUMANBioGRID14614461 details
GRM1_HUMANAA1R_HUMANBioGRID11278325 details
GRM1_HUMANARBK1_HUMANBioGRID16091361 details
GRM1_HUMANHD_HUMANBioGRID16091361 details
GRM1_HUMANHOME1_HUMANBioGRID11418862 details
GRM1_HUMANGRASP_HUMANBioGRID15173175 details
GRM1_HUMANSRC_HUMANBioGRID15173175 details
GRM1_HUMANFYN_HUMANBioGRID15173175 details
GRM1_HUMANKSYK_HUMANBioGRID15173175 details
GRM1_HUMANFAK2_HUMANBioGRID20180987 details
GRM1_HUMANARRB1_HUMANBioGRID11723231 details
GRM1_HUMANARRB2_HUMANBioGRID11723231 details