Entity Details

Primary name CUL3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13618
EntryNameCUL3_HUMAN
FullNameCullin-3
TaxID9606
Evidenceevidence at protein level
Length768
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesCUL3

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000165 MAPK cascade
GO:0000209 protein polyubiquitination
GO:0000922 spindle pole
GO:0001831 trophectodermal cellular morphogenesis
GO:0005112 Notch binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005827 polar microtubule
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006513 protein monoubiquitination
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0007080 mitotic metaphase plate congression
GO:0007229 integrin-mediated signaling pathway
GO:0007369 gastrulation
GO:0008284 positive regulation of cell population proliferation
GO:0016020 membrane
GO:0016055 Wnt signaling pathway
GO:0016477 cell migration
GO:0016567 protein ubiquitination
GO:0017145 stem cell division
GO:0030030 cell projection organization
GO:0030332 cyclin binding
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0031208 POZ domain binding
GO:0031398 positive regulation of protein ubiquitination
GO:0031461 cullin-RING ubiquitin ligase complex
GO:0031463 Cul3-RING ubiquitin ligase complex
GO:0031625 ubiquitin protein ligase binding
GO:0031648 protein destabilization
GO:0032467 positive regulation of cytokinesis
GO:0035024 negative regulation of Rho protein signal transduction
GO:0036126 sperm flagellum
GO:0040016 embryonic cleavage
GO:0043149 stress fiber assembly
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043687 post-translational protein modification
GO:0044346 fibroblast apoptotic process
GO:0045842 positive regulation of mitotic metaphase/anaphase transition
GO:0048208 COPII vesicle coating
GO:0051865 protein autoubiquitination
GO:0061630 ubiquitin protein ligase activity
GO:0070062 extracellular exosome
GO:0071630 nuclear protein quality control by the ubiquitin-proteasome system
GO:0072576 liver morphogenesis
GO:0072686 mitotic spindle
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097193 intrinsic apoptotic signaling pathway
GO:1901992 positive regulation of mitotic cell cycle phase transition

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm
Golgi apparatus
Nucleus

Domains

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DomainNameCategoryType
IPR001373 Cullin, N-terminalDomainDomain
IPR016157 Cullin, conserved siteSiteConserved site
IPR016158 Cullin homology domainDomainDomain
IPR016159 Cullin repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR019559 Cullin protein, neddylation domainDomainDomain
IPR036317 Cullin homology domain superfamilyFamilyHomologous superfamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

210 interactions

InteractorPartnerSourcesPublicationsLink
CUL3_HUMANCSN5_HUMANBioGRID, IntAct18850735 19295130 19615732 21145461 22013077 28514442 29897280 32047038 details
CUL3_HUMANGBRL1_HUMANBioGRID, IntAct20562859 25684205 details
CUL3_HUMANDMB_HUMANBioGRID, IntAct21988832 details
CUL3_HUMANELOC_HUMANBioGRID, IntAct21145461 21988832 details
CUL3_HUMANDCNL1_HUMANBioGRID, DIP, IntAct18826954 19617556 21145461 23201271 24192928 25349211 26344197 26906416 28514442 30587576 details
CUL3_HUMANRHBT1_HUMANBioGRID, IntAct18835386 21145461 23040068 26100637 30896450 31431478 details
CUL3_HUMANABTB1_HUMANBioGRID, IntAct21145461 25416956 31515488 details
CUL3_HUMANBTBD1_HUMANBioGRID, IntAct17543862 19295130 19995937 21145461 25011449 28514442 32296183 details
CUL3_HUMANCSN2_HUMANBioGRID, IntAct16045761 19295130 21145461 26976604 28514442 32047038 details
CUL3_HUMANBTBD2_HUMANBioGRID, IntAct17543862 19295130 19995937 21145461 32296183 details
CUL3_HUMANKBTB8_HUMANBioGRID, IntAct21145461 26399832 29999490 30190310 details
CUL3_HUMANKCD17_HUMANBioGRID, IntAct21145461 25270598 26334369 28963344 33130828 details
CUL3_HUMANKLHL3_HUMANBioGRID, IntAct, MINT23387299 23453970 23573258 23576762 23665031 23838290 25250572 25416956 25502805 26100637 26286618 30819806 31515488 32296183 details
CUL3_HUMANMTR1B_HUMANBioGRID, IntAct26514267 details
CUL3_HUMANDCNL3_HUMANBioGRID, DIP19617556 23201271 25349211 26906416 details
CUL3_HUMANRBX1_HUMANBioGRID, DIP, HPRD11311237 11861641 12481031 12684064 15448697 15601839 19250909 19256485 19617556 19818716 20027226 22405651 24145166 25270598 25278611 26100637 26286618 29958295 30349055 details
CUL3_HUMANCUL3_HUMANBioGRID, DIP17192413 17254749 19617556 21145461 22709582 22911784 26100637 26286618 details
CUL3_HUMANHSF2_HUMANBioGRID19768582 details
CUL3_HUMANUBC_HUMANBioGRID17550899 19295130 21145461 27001857 details
CUL3_HUMANNEDD8_HUMANBioGRID, HPRD, IntAct, MINT10500095 16503656 16620772 17192413 18274552 21145461 details
CUL3_HUMANOLIG2_HUMANBioGRID, IntAct21988832 details
CUL3_HUMANSPOP_HUMANBioGRID, I2D, IntAct16524876 19256485 19261606 21577200 21988832 22013077 22632832 22911784 25011449 25278611 28216678 29160310 30244836 31559706 details
CUL3_HUMANBTBDA_HUMANBioGRID, IntAct21145461 21988832 28514442 details
CUL3_HUMANSHKB1_HUMANBioGRID, IntAct21145461 21988832 28963344 32296183 details
CUL3_HUMANKEAP1_HUMANBioGRID, IntAct15282312 15367669 15572695 15601839 15983046 16449638 16790436 17439941 17822677 18251510 18417180 19818716 20027226 20421418 20534351 20599909 21145461 21357422 22245129 22558124 22911784 23727018 24322982 24896564 25628777 25742418 26219975 26757824 28186440 30273379 30383469 30765703 32296183 32341456 32854194 33130828 details
CUL3_HUMANKCTD7_HUMANBioGRID, IntAct21145461 22748208 30295347 32296183 details
CUL3_HUMANKCTD6_HUMANBioGRID, IntAct, MINT21145461 22573887 25416956 25974686 26334369 27152988 27621083 28514442 32296183 details
CUL3_HUMANBACD2_HUMANBioGRID, IntAct19782033 21145461 22810651 25416956 28514442 33130828 details
CUL3_HUMANBACD3_HUMANBioGRID, IntAct19295130 21145461 25401743 28499918 28514442 28963344 30404837 32296183 details
CUL3_HUMANACLY_HUMANBioGRID, IntAct21145461 27664236 details
CUL3_HUMANRBX2_HUMANBioGRID19250909 details
CUL3_HUMANEFNB1_HUMANBioGRID, IntAct21988832 details
CUL3_HUMANKLHL5_HUMANBioGRID, IntAct21145461 21988832 31652307 details
CUL3_HUMANKLH12_HUMANBioGRID, HPRD, IntAct16547521 17543862 18303015 19295130 21145461 25416956 27716508 29999490 30190310 32296183 details
CUL3_HUMANKLHL2_HUMANBioGRID, IntAct21145461 23838290 25416956 28514442 31515488 details
CUL3_HUMANKCTD2_HUMANBioGRID, IntAct21145461 28060381 28514442 details
CUL3_HUMANRHBT3_HUMANBioGRID, IntAct18835386 21145461 24145166 28514442 details
CUL3_HUMANBTBD6_HUMANBioGRID, IntAct32296183 details
CUL3_HUMANCCNE1_HUMANBioGRID, HPRD10500095 17192413 27477274 31636116 details
CUL3_HUMANUBC12_HUMANBioGRID21247897 26286618 28475037 28581483 details
CUL3_HUMANCAND1_HUMANBioGRID, HPRD, IntAct12609982 16449638 21145461 21249194 22013077 22405651 26286618 details
CUL3_HUMANWNT7B_HUMANBioGRID, IntAct21988832 details
CUL3_HUMANKCTD9_HUMANBioGRID, IntAct21145461 25416956 26334369 28514442 32296183 33130828 details
CUL3_HUMANPEF1_HUMANBioGRID, IntAct21145461 27716508 details
CUL3_HUMANKCTD5_HUMANBioGRID, IntAct18573101 21145461 24747150 26334369 28963344 33130828 details
CUL3_HUMANKCD11_HUMANBioGRID20081843 21237243 25974686 details
CUL3_HUMANDCNL5_HUMANBioGRID23201271 24192928 26906416 details
CUL3_HUMANBACD1_HUMANBioGRID, IntAct19782033 21145461 25416956 26100637 28514442 28963344 32296183 details
CUL3_HUMANMLP3B_HUMANBioGRID25684205 details
CUL3_HUMANGBRAP_HUMANBioGRID, IntAct20562859 25684205 details
CUL3_HUMANKCC1D_HUMANBioGRID, IntAct21988832 details
CUL3_HUMANKLH42_HUMANBioGRID, IntAct19256485 19261606 19295130 21145461 25011449 28514442 33130828 details
CUL3_HUMANZMAT4_HUMANBioGRID, IntAct25416956 32296183 details
CUL3_HUMANABTB2_HUMANBioGRID, HPRD18429817 18459963 details
CUL3_HUMANMTR1A_HUMANBioGRID, IntAct26514267 details
CUL3_HUMANBTBD3_HUMANBioGRID, IntAct32296183 details
CUL3_HUMANDCNL2_HUMANBioGRID, DIP19617556 23201271 26906416 details
CUL3_HUMANRHBT2_HUMANBioGRID, IntAct, MINT15107402 18835386 21145461 29276004 details
CUL3_HUMANGMCL1_HUMANBioGRID, IntAct21145461 25416956 31515488 32296183 details
CUL3_HUMANUB2R1_HUMANBioGRID19256485 details
CUL3_HUMANA4_HUMANBioGRID21244100 21832049 details
CUL3_HUMANKLH20_HUMANBioGRID, IntAct, MINT20389280 21145461 24768539 25619834 28514442 details
CUL3_HUMANUB2E1_HUMANBioGRID19256485 details
CUL3_HUMANDYRK4_HUMANBioGRID, IntAct21988832 details
CUL3_HUMANMLP3C_HUMANBioGRID25684205 details
CUL3_HUMANMETK2_HUMANBioGRID, IntAct21145461 27213918 details
CUL3_HUMANUB2E2_HUMANBioGRID19256485 details
CUL3_HUMANRCBT2_HUMANBioGRID19256485 details
CUL3_HUMANCOMD1_HUMANBioGRID21778237 details
CUL3_HUMANDCNL4_HUMANBioGRID23201271 26906416 details
CUL3_HUMANFOLR1_HUMANBioGRID, IntAct21988832 details
CUL3_HUMANARHGC_HUMANBioGRID21670212 details
CUL3_HUMANCTIP_HUMANBioGRID27561354 details
CUL3_HUMANGBRL2_HUMANBioGRID, IntAct20562859 25684205 details
CUL3_HUMANUB2D1_HUMANBioGRID17543862 details
CUL3_HUMANMPIP1_HUMANBioGRID, IntAct21988832 details
CUL3_HUMANRCBT1_HUMANBioGRID, IntAct19256485 21145461 details
CUL3_HUMANHD_HUMANIntAct32814053 details
CUL3_HUMANUB2E3_HUMANBioGRID19256485 details
CUL3_HUMANPDCD6_HUMANBioGRID27716508 details
CUL3_HUMANCLK1_HUMANBioGRID26167880 details
CUL3_HUMANUBS3B_HUMANBioGRID26766443 details
CUL3_HUMANPDIA2_HUMANBioGRID19261606 details
CUL3_HUMANUB2D2_HUMANBioGRID19256485 details
CUL3_HUMANCASP8_HUMANBioGRID, IntAct19427028 23142077 25551360 28574503 details
CUL3_HUMANKLH25_HUMANBioGRID, IntAct21145461 22578813 27664236 28514442 33130828 details
CUL3_HUMANKLHL8_HUMANBioGRID, IntAct19158078 21145461 28514442 33130828 details
CUL3_HUMANKLHL9_HUMANBioGRID, IntAct17543862 19295130 19995937 21145461 31515271 33130828 details
CUL3_HUMANKLH21_HUMANBioGRID, IntAct19995937 21145461 27387502 28514442 33130828 details
CUL3_HUMANIBTK_HUMANBioGRID, IntAct21145461 25882842 28514442 29395067 29695787 33130828 details
CUL3_HUMANMCM7_HUMANBioGRID, IntAct21145461 26188516 details
CUL3_HUMANTERA_HUMANBioGRID, IntAct21145461 22466964 details
CUL3_HUMANATF2_HUMANBioGRID18397884 details
CUL3_HUMANTULP3_HUMANBioGRID33187986 details
CUL3_HUMANKBTB7_HUMANBioGRID, IntAct20562859 21145461 25684205 28514442 33130828 details
CUL3_HUMANCUL5_HUMANBioGRID, IntAct21145461 22709582 details
CUL3_HUMANSC31A_HUMANBioGRID, IntAct21145461 27716508 details
CUL3_HUMANCSN8_HUMANBioGRID, IntAct21145461 26286618 details
CUL3_HUMANKLH13_HUMANBioGRID, IntAct17543862 19295130 19995937 21145461 30190310 31515271 33130828 details
CUL3_HUMANGAN_HUMANBioGRID, IntAct15983046 21145461 31944090 details
CUL3_HUMANELOA1_HUMANBioGRID, IntAct27173435 unassigned1312 details
CUL3_HUMANBRMS1_HUMANBioGRID22085717 details
CUL3_HUMANZN711_HUMANBioGRID26188516 details
CUL3_HUMANDVL2_HUMANBioGRID27477274 details
CUL3_HUMANTNF10_HUMANBioGRID, IntAct19427028 25551360 details
CUL3_HUMANDAPK1_HUMANBioGRID, MINT20389280 details
CUL3_HUMANCSN7A_HUMANBioGRID, IntAct19295130 21145461 27833851 28514442 details
CUL3_HUMANSF3B3_HUMANBioGRID, IntAct21145461 23951410 details
CUL3_HUMANENC1_HUMANBioGRID, IntAct15983046 21145461 28514442 details
CUL3_HUMANCSN7B_HUMANBioGRID, IntAct21145461 27833851 28514442 details
CUL3_HUMANKLH22_HUMANBioGRID, IntAct17543862 19295130 19995937 21145461 27561354 28514442 33130828 details
CUL3_HUMANCSN3_HUMANBioGRID, IntAct16036220 19295130 21145461 28514442 details
CUL3_HUMANCSN4_HUMANBioGRID, IntAct19295130 21145461 28514442 details
CUL3_HUMANKBTB6_HUMANBioGRID, IntAct19295130 21145461 25684205 28514442 details
CUL3_HUMANKLH11_HUMANBioGRID, IntAct21145461 23349464 28514442 33130828 details
CUL3_HUMANKBTB2_HUMANBioGRID, IntAct21145461 27708159 28514442 details
CUL3_HUMANANFY1_HUMANBioGRID, IntAct21145461 29038302 details
CUL3_HUMANP85A_HUMANBioGRID, IntAct21145461 27708159 details
CUL3_HUMANLZTR1_HUMANBioGRID, IntAct21145461 30442762 30442766 30481304 30872527 details
CUL3_HUMANERG_HUMANBioGRID26344095 details
CUL3_HUMANEGLN2_HUMANBioGRID28089830 details
CUL3_HUMANTNAP3_HUMANBioGRID28574503 details
CUL3_HUMANKBTBB_HUMANBioGRID30837587 details
CUL3_HUMANCSN1_HUMANBioGRID, DIP, HPRD, IntAct11337588 21145461 27029275 28514442 details
CUL3_HUMANKLH18_HUMANBioGRID, IntAct19295130 21145461 23213400 28514442 33130828 details
CUL3_HUMANKLHL7_HUMANBioGRID, IntAct, UniProt21145461 21828050 28514442 details
CUL3_HUMANCH60_HUMANBioGRID, IntAct12684064 21145461 details
CUL3_HUMANNSF1C_HUMANBioGRID18775313 details
CUL3_HUMANDDIT3_HUMANBioGRID23213463 details
CUL3_HUMANF193B_HUMANBioGRID26188516 details
CUL3_HUMANGLI2_HUMANBioGRID27477274 details
CUL3_HUMANRASK_HUMANBioGRID31337872 details
CUL3_HUMANUBXN7_HUMANBioGRID, DIP, IntAct18775313 22466964 details
CUL3_HUMANTR10A_HUMANBioGRID, IntAct19427028 23142077 details
CUL3_HUMANFUBP2_HUMANBioGRID, IntAct21145461 27899653 details
CUL3_HUMANKLH41_HUMANBioGRID15983046 details
CUL3_HUMANFAF2_HUMANBioGRID18775313 details
CUL3_HUMANFMOD_HUMANBioGRID25011449 details
CUL3_HUMANAURKA_HUMANBioGRID23213400 details
CUL3_HUMANPHLP2_HUMANBioGRID28859855 details
CUL3_HUMANEIF3D_HUMANBioGRID31280863 details
CUL3_HUMANRBM45_HUMANBioGRID, IntAct21145461 25939382 details
CUL3_HUMANNF2L2_HUMANBioGRID15367669 15601839 details
CUL3_HUMANAURKB_HUMANBioGRID17543862 26766443 details
CUL3_HUMANCSK2B_HUMANBioGRID31901862 details
CUL3_HUMANKLH15_HUMANBioGRID, IntAct21145461 23135275 27561354 28514442 33130828 details
CUL3_HUMANRHOA_HUMANBioGRID19782033 28499918 30287810 details
CUL3_HUMAN5HT7R_HUMANBioGRID22245496 details
CUL3_HUMANESR1_HUMANBioGRID18414007 details
CUL3_HUMANTR10B_HUMANBioGRID23142077 32313199 details
CUL3_HUMANCDC20_HUMANBioGRID27780719 details
CUL3_HUMANPD1L1_HUMANBioGRID29160310 details
CUL3_HUMANHS90A_HUMANBioGRID, IntAct21145461 22939624 details
CUL3_HUMANBCL6_HUMANBioGRID24863065 details
CUL3_HUMANUBP21_HUMANBioGRID27621083 details
CUL3_HUMANLNP_HUMANBioGRID27716508 32433973 details
CUL3_HUMANHS90B_HUMANBioGRID, IntAct21145461 22939624 details
CUL3_HUMANCCD22_HUMANBioGRID, UniProt23563313 details
CUL3_HUMANPMS1_HUMANBioGRID17148452 details
CUL3_HUMANSOX9_HUMANBioGRID33173725 details
CUL3_HUMANKLHL4_HUMANBioGRID, IntAct21145461 32753315 details
CUL3_HUMANHSP74_HUMANBioGRID, IntAct12684064 21145461 details
CUL3_HUMANPGAM5_HUMANBioGRID, IntAct17046835 21145461 details
CUL3_HUMANKTNA1_HUMANBioGRID19261606 26344197 details
CUL3_HUMANRHG07_HUMANBioGRID24082123 details
CUL3_HUMANARRB2_HUMANBioGRID27155323 details
CUL3_HUMANSUMO3_HUMANHPRD16620772 details
CUL3_HUMANCSN9_HUMANBioGRID, IntAct21145461 23776465 details
CUL3_HUMANPSA7_HUMANBioGRID17699672 details
CUL3_HUMANWNK4_HUMANBioGRID23453970 23576762 details
CUL3_HUMANKLHL6_HUMANBioGRID28807996 29695787 details
CUL3_HUMANMBD3_HUMANBioGRID33016927 details
CUL3_HUMANIKKB_HUMANBioGRID19818716 details
CUL3_HUMANSENP3_HUMANBioGRID26511642 details
CUL3_HUMANPML_HUMANIntAct21840486 details
CUL3_HUMANKAT5_HUMANBioGRID18397884 details
CUL3_HUMANFADD_HUMANBioGRID23142077 details
CUL3_HUMANMS18B_HUMANBioGRID24269809 details
CUL3_HUMANCAV1_HUMANBioGRID28499918 details
CUL3_HUMANPTC1_HUMANBioGRID26885983 details
CUL3_HUMANSHLD2_HUMANBioGRID30154076 details
CUL3_HUMANSQSTM_HUMANBioGRID20421418 26349538 28574503 details
CUL3_HUMAN2ABB_HUMANBioGRID23135275 details
CUL3_HUMANDRD4_HUMANBioGRID18303015 26717573 details
CUL3_HUMANDNM3B_HUMANBioGRID20847044 details
CUL3_HUMANGLMN_HUMANBioGRID22405651 details
CUL3_HUMANBRD4_HUMANBioGRID28805820 32416067 details
CUL3_HUMANNANOG_HUMANBioGRID30595538 details
CUL3_HUMANCASP1_HUMANBioGRID28247911 details
CUL3_HUMANCCND1_HUMANHPRD10500095 details
CUL3_HUMANCDC37_HUMANIntAct22939624 details
CUL3_HUMANNACC1_HUMANBioGRID17699672 details
CUL3_HUMANLLR1_HUMANBioGRID25011449 details
CUL3_HUMANRIT1_HUMANHPRD18303015 details
CUL3_HUMANNOTC1_HUMANBioGRID25401743 details
CUL3_HUMANPLK1_HUMANBioGRID31815296 details
CUL3_HUMANNCOA3_HUMANBioGRID22147914 details
CUL3_HUMANKBTBD_HUMANBioGRID22542517 details
CUL3_HUMANRPB1_HUMANBioGRID30349055 details
CUL3_HUMANIRS1_HUMANBioGRID31515271 details
CUL3_HUMANTDT_HUMANBioGRID18429817 details
CUL3_HUMANBMI1_HUMANBioGRID15897469 details
CUL3_HUMANDAXX_HUMANBioGRID16524876 details
CUL3_HUMANARRB1_HUMANBioGRID27155323 details
CUL3_HUMANANK1_HUMANBioGRID22573887 details
CUL3_HUMANRAB18_HUMANBioGRID28499918 details
CUL3_HUMANH2AY_HUMANBioGRID15897469 details
CUL3_HUMANHDAC6_HUMANBioGRID28599312 details
CUL3_HUMANLATS1_HUMANBioGRID32460168 details
CUL3_HUMANSUMO2_HUMANHPRD16620772 details