Entity Details

Primary name CAC1S_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13698
EntryNameCAC1S_HUMAN
FullNameVoltage-dependent L-type calcium channel subunit alpha-1S
TaxID9606
Evidenceevidence at protein level
Length1873
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesCACNA1S

GO terms

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GOName
GO:0005245 voltage-gated calcium channel activity
GO:0005516 calmodulin binding
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0006816 calcium ion transport
GO:0006936 muscle contraction
GO:0008331 high voltage-gated calcium channel activity
GO:0030315 T-tubule
GO:0031674 I band
GO:0034765 regulation of ion transmembrane transport
GO:0046872 metal ion binding
GO:0070509 calcium ion import
GO:0071313 cellular response to caffeine
GO:1990454 L-type voltage-gated calcium channel complex

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR002077 Voltage-dependent calcium channel, alpha-1 subunitFamilyFamily
IPR005446 Voltage-dependent calcium channel, L-type, alpha-1 subunitFamilyFamily
IPR005450 Voltage-dependent calcium channel, L-type, alpha-1S subunitFamilyFamily
IPR005821 Ion transport domainDomainDomain
IPR014873 Voltage-dependent calcium channel, alpha-1 subunit, IQ domainDomainDomain
IPR027359 Voltage-dependent channel domain superfamilyFamilyHomologous superfamily
IPR031649 Voltage-dependent L-type calcium channel, IQ-associated domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00153 ErgocalciferolDrugbanksmall molecule
DB00228 EnfluraneDrugbanksmall molecule
DB00243 RanolazineDrugbanksmall molecule
DB00252 PhenytoinDrugbanksmall molecule
DB00270 IsradipineDrugbanksmall molecule
DB00273 TopiramateDrugbanksmall molecule
DB00393 NimodipineDrugbanksmall molecule
DB00401 NisoldipineDrugbanksmall molecule
DB00421 SpironolactoneDrugbanksmall molecule
DB00568 CinnarizineDrugbanksmall molecule
DB00653 Magnesium sulfateDrugbanksmall molecule
DB00825 LevomentholDrugbanksmall molecule
DB00898 EthanolDrugbanksmall molecule
DB01023 FelodipineDrugbanksmall molecule
DB01054 NitrendipineDrugbanksmall molecule
DB01110 MiconazoleDrugbanksmall molecule
DB01115 NifedipineDrugbanksmall molecule
DB01118 AmiodaroneDrugbanksmall molecule
DB01388 MibefradilDrugbanksmall molecule
DB04855 DronedaroneDrugbanksmall molecule
DB04920 ClevidipineDrugbanksmall molecule
DB06712 NilvadipineDrugbanksmall molecule
DB09089 TrimebutineDrugbanksmall molecule
DB09090 PinaveriumDrugbanksmall molecule
DB09229 AranidipineDrugbanksmall molecule
DB09231 BenidipineDrugbanksmall molecule
DB09232 CilnidipineDrugbanksmall molecule
DB09236 LacidipineDrugbanksmall molecule
DB09238 ManidipineDrugbanksmall molecule
DB11093 Calcium citrateDrugbanksmall molecule
DB11148 ButambenDrugbanksmall molecule
DB11348 Calcium PhosphateDrugbanksmall molecule
DB13746 BioallethrinDrugbanksmall molecule
DB13961 Fish oilDrugbankbiotech
DB14481 Calcium phosphate dihydrateDrugbanksmall molecule