Entity Details

Primary name KEAP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14145
EntryNameKEAP1_HUMAN
FullNameKelch-like ECH-associated protein 1
TaxID9606
Evidenceevidence at protein level
Length624
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesKEAP1

GO terms

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GOName
GO:0001701 in utero embryonic development
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005884 actin filament
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0008134 transcription factor binding
GO:0010506 regulation of autophagy
GO:0016032 viral process
GO:0016234 inclusion body
GO:0016567 protein ubiquitination
GO:0016579 protein deubiquitination
GO:0030496 midbody
GO:0031463 Cul3-RING ubiquitin ligase complex
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034451 centriolar satellite
GO:0034599 cellular response to oxidative stress
GO:0042802 identical protein binding
GO:0042994 cytoplasmic sequestering of transcription factor
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043687 post-translational protein modification
GO:0045604 regulation of epidermal cell differentiation
GO:0071353 cellular response to interleukin-4
GO:0097718 disordered domain specific binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000210 BTB/POZ domainDomainDomain
IPR006652 Kelch repeat type 1RepeatRepeat
IPR011333 SKP1/BTB/POZ domain superfamilyFamilyHomologous superfamily
IPR011705 BTB/Kelch-associatedDomainDomain
IPR015915 Kelch-type beta propellerFamilyHomologous superfamily
IPR017096 BTB-kelch proteinFamilyFamily
IPR030563 Kelch-like ECH-associated protein 1FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB08908 Dimethyl fumarateDrugbanksmall molecule

Interactions

137 interactions

InteractorPartnerSourcesPublicationsLink
KEAP1_HUMANNF2L2_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt11439354 11909699 12145307 14517290 14585973 15475350 15572695 15601839 15985429 16006525 16449638 16790436 16888629 17015834 17462537 17822677 18387606 18417180 18757741 18981988 19706542 20027226 20421418 20463144 20484052 20486933 20599909 21262351 21383067 21988832 22215675 22245129 22302998 22331464 22558124 23066931 23382044 23645672 23722832 23727018 23857982 23986495 24011591 24130096 24322982 24512214 24704364 24844779 25582950 25628777 26078718 26536456 27091842 27212020 27621311 28186440 28416489 28533375 28534518 28617433 28638054 28939422 29033244 29255090 29423025 29792731 30122040 30126895 30383469 30465941 30473361 30576774 30692632 30765703 30778200 30793592 31169361 31257023 31262713 31541481 31695040 31891690 32057361 32159343 32206121 32605589 32854194 32911434 9887101 details
KEAP1_HUMANT22D4_HUMANBioGRID, IntAct19615732 21988832 23382044 26186194 details
KEAP1_HUMANPTMA_HUMANBioGRID, IntAct23318954 25416956 25582950 32296183 details
KEAP1_HUMANF117B_HUMANBioGRID, IntAct23382044 25416956 32296183 details
KEAP1_HUMANCB068_HUMANBioGRID, IntAct32296183 details
KEAP1_HUMANSTK4_HUMANBioGRID30765703 details
KEAP1_HUMANERF1_HUMANBioGRID, HPRD, IntAct16189514 19615732 25416956 29395067 32296183 details
KEAP1_HUMANSQSTM_HUMANBioGRID, IntAct, UniProt19615732 20173742 20378532 20421418 20452972 20495340 20562859 21482715 23117207 23242280 23795962 24011591 24322982 25416956 25505069 25910212 25939382 26043024 27554286 27631370 28380357 28416489 28617433 28820283 28846113 29033244 30126895 30581152 30907226 31169361 32296183 34079125 details
KEAP1_HUMANNF2L1_HUMANBioGRID, IntAct16687406 21262351 21988832 29255090 30126895 details
KEAP1_HUMANCUL3_HUMANBioGRID, IntAct15282312 15367669 15572695 15601839 15983046 16449638 16790436 17439941 17822677 18251510 18417180 19818716 20027226 20421418 20534351 20599909 21145461 21357422 22245129 22558124 22911784 23727018 24322982 24896564 25628777 25742418 26219975 26757824 28186440 30273379 30383469 30765703 32296183 32341456 32854194 33130828 details
KEAP1_HUMANZSC32_HUMANBioGRID, IntAct25416956 details
KEAP1_HUMANNUP50_HUMANBioGRID, IntAct32296183 details
KEAP1_HUMANKLHL2_HUMANBioGRID, IntAct15383316 28514442 30190310 32296183 details
KEAP1_HUMANAMER1_HUMANbhf-ucl, BioGRID17510365 22215675 24322982 details
KEAP1_HUMANRAF1_HUMANBioGRID, IntAct28205554 31980649 details
KEAP1_HUMANGRN_HUMANIntAct32814053 details
KEAP1_HUMANSPRE1_HUMANIntAct32814053 details
KEAP1_HUMANCPEB2_HUMANBioGRID22157746 details
KEAP1_HUMANDPP3_HUMANBioGRID, IntAct, MINT19615732 21516116 23382044 24322982 25416956 28416489 32296183 details
KEAP1_HUMANMABP1_HUMANBioGRID, IntAct25416956 details
KEAP1_HUMANWDR83_HUMANBioGRID, IntAct25416956 31515488 32296183 details
KEAP1_HUMANIQCC_HUMANBioGRID, IntAct32296183 details
KEAP1_HUMANEAF1_HUMANBioGRID, IntAct32296183 details
KEAP1_HUMANCO1A1_HUMANBioGRID, IntAct32296183 details
KEAP1_HUMANPALB2_HUMANBioGRID, DIP, IntAct22331464 25016020 26649820 28398198 28416489 30126895 31257023 32296183 details
KEAP1_HUMANICAM1_HUMANBioGRID, IntAct32296183 details
KEAP1_HUMANKEAP1_HUMANBioGRID12145307 15983046 16790436 17254749 20599909 24322982 25742418 28205554 30126895 30323285 30765703 details
KEAP1_HUMANUBC_HUMANBioGRID25505069 25742418 28190767 details
KEAP1_HUMANRSMN_HUMANBioGRID, IntAct21988832 details
KEAP1_HUMANKAD4_HUMANBioGRID, MINT21900206 details
KEAP1_HUMANIKKB_HUMANBioGRID, IntAct19818716 20600852 24322982 25926686 27387502 30126895 30500824 details
KEAP1_HUMANCDK6_HUMANBioGRID28205554 details
KEAP1_HUMANMCMBP_HUMANBioGRID, IntAct19615732 25036637 27621311 32296183 details
KEAP1_HUMANPDC6I_HUMANBioGRID, IntAct21988832 details
KEAP1_HUMANGLPA_HUMANBioGRID, IntAct25416956 25910212 31515488 32296183 details
KEAP1_HUMANZN121_HUMANBioGRID, IntAct32296183 details
KEAP1_HUMANASTN1_HUMANBioGRID, UniProt31169361 details
KEAP1_HUMANIRF1_HUMANBioGRID21903422 details
KEAP1_HUMANHS90A_HUMANBioGRID26517842 details
KEAP1_HUMANUB2D1_HUMANBioGRID33173725 details
KEAP1_HUMANCLUS_HUMANBioGRID, IntAct21988832 details
KEAP1_HUMANNUDT4_HUMANBioGRID, IntAct25416956 details
KEAP1_HUMANATG5_HUMANBioGRID, IntAct25416956 31515488 32296183 details
KEAP1_HUMANTBCD7_HUMANBioGRID, IntAct32296183 details
KEAP1_HUMANKLHL3_HUMANBioGRID, IntAct25416956 32296183 details
KEAP1_HUMANCAR10_HUMANBioGRID, IntAct32296183 details
KEAP1_HUMANMD2L1_HUMANBioGRID, IntAct19615732 23382044 25416956 31515488 32296183 details
KEAP1_HUMANNIBA2_HUMANBioGRID, IntAct, UniProt19615732 28416489 31262713 details
KEAP1_HUMANPIDD1_HUMANBioGRID, IntAct21988832 31455821 details
KEAP1_HUMANLSM3_HUMANBioGRID, IntAct25416956 32296183 details
KEAP1_HUMANOXR1_HUMANBioGRID, IntAct25416956 details
KEAP1_HUMANCSK21_HUMANBioGRID, IntAct32296183 details
KEAP1_HUMANWFS1_HUMANIntAct32814053 details
KEAP1_HUMANBPTF_HUMANBioGRID, HPRD15379550 details
KEAP1_HUMANTET2_HUMANBioGRID30404004 details
KEAP1_HUMANNTAQ1_HUMANBioGRID, IntAct32296183 details
KEAP1_HUMANMCM3_HUMANBioGRID23382044 24322982 27621311 28416489 30108253 30126895 details
KEAP1_HUMANTET5A_HUMANBioGRID, HPRD15231748 details
KEAP1_HUMANRECK_HUMANBioGRID25416956 32296183 details
KEAP1_HUMANCIP1_HUMANBioGRID, IntAct25416956 31515488 details
KEAP1_HUMANTERF1_HUMANbhf-ucl, BioGRID21044950 details
KEAP1_HUMANWHRN_HUMANBioGRID, IntAct32296183 details
KEAP1_HUMANERIC5_HUMANBioGRID, IntAct32296183 details
KEAP1_HUMANSTK3_HUMANBioGRID30765703 details
KEAP1_HUMANGLRX5_HUMANBioGRID, IntAct21988832 details
KEAP1_HUMANUBP15_HUMANBioGRID23727018 details
KEAP1_HUMANLTOR5_HUMANBioGRID30692632 details
KEAP1_HUMANCATA_HUMANBioGRID, IntAct21988832 details
KEAP1_HUMANGP151_HUMANBioGRID, IntAct32296183 details
KEAP1_HUMANTF65_HUMANBioGRID, IntAct21262351 21988832 details
KEAP1_HUMANAAKG1_HUMANBioGRID, IntAct25416956 32296183 details
KEAP1_HUMANSTAP2_HUMANBioGRID, IntAct32296183 details
KEAP1_HUMANIFIH1_HUMANBioGRID, IntAct32296183 details
KEAP1_HUMANCADH1_HUMANBioGRID22302998 25468996 details
KEAP1_HUMANEGFR_HUMANBioGRID25628777 details
KEAP1_HUMANSRC8_HUMANBioGRID26602019 details
KEAP1_HUMANDDIT4_HUMANIntAct32814053 details
KEAP1_HUMANMYO7A_HUMANBioGRID, HPRD11921171 details
KEAP1_HUMANCO2A1_HUMANBioGRID, IntAct32296183 details
KEAP1_HUMANACY2_HUMANIntAct25910212 details
KEAP1_HUMANIMA7_HUMANBioGRID21383067 details
KEAP1_HUMANLAMC1_HUMANBioGRID31169361 details
KEAP1_HUMANTRI15_HUMANBioGRID25450970 details
KEAP1_HUMANIASPP_HUMANBioGRID29033244 details
KEAP1_HUMANITB2_HUMANIntAct32814053 details
KEAP1_HUMANIPO11_HUMANBioGRID21383067 details
KEAP1_HUMANPAQR4_HUMANBioGRID32206121 details
KEAP1_HUMANSMRD1_HUMANBioGRID, IntAct32296183 details
KEAP1_HUMANNUD4B_HUMANBioGRID25416956 details
KEAP1_HUMANHS90B_HUMANBioGRID26517842 details
KEAP1_HUMANBAD_HUMANBioGRID, IntAct21988832 details
KEAP1_HUMANANS1A_HUMANBioGRID32296183 details
KEAP1_HUMANMLP3A_HUMANBioGRID, IntAct20495340 20562859 24067654 details
KEAP1_HUMANFKBPL_HUMANIntAct25036637 details
KEAP1_HUMANNEIL2_HUMANBioGRID20534351 details
KEAP1_HUMANRAD51_HUMANBioGRID22331464 details
KEAP1_HUMANTERA_HUMANBioGRID30126895 details
KEAP1_HUMANSLK_HUMANBioGRID, IntAct19615732 23382044 24322982 details
KEAP1_HUMANRBX1_HUMANBioGRID15572695 15983046 16449638 20027226 20421418 22558124 details
KEAP1_HUMANRBM45_HUMANBioGRID, IntAct19615732 25939382 details
KEAP1_HUMANNEMO_HUMANBioGRID, IntAct20600852 30500824 details
KEAP1_HUMANSESN1_HUMANBioGRID, IntAct23274085 details
KEAP1_HUMANMCM2_HUMANBioGRID27621311 details
KEAP1_HUMANCUL2_HUMANBioGRID15572695 details
KEAP1_HUMANSOX9_HUMANBioGRID33173725 details
KEAP1_HUMANPGAM5_HUMANBioGRID, IntAct17046835 18387606 19615732 28416489 30126895 details
KEAP1_HUMANCASP1_HUMANBioGRID28247911 details
KEAP1_HUMANNOS3_HUMANBioGRID31491600 details
KEAP1_HUMANGABPA_HUMANBioGRID17439941 19424503 details
KEAP1_HUMANT22D2_HUMANBioGRID23382044 details
KEAP1_HUMANPAQR3_HUMANBioGRID27212020 details
KEAP1_HUMANBRCA2_HUMANBioGRID22331464 28416489 details
KEAP1_HUMANPSD10_HUMANBioGRID27091842 details
KEAP1_HUMANPSMD4_HUMANBioGRID30126895 details
KEAP1_HUMANWDR1_HUMANBioGRID23382044 details
KEAP1_HUMANPK3C3_HUMANBioGRID30126895 details
KEAP1_HUMANNUDC3_HUMANIntAct25036637 details
KEAP1_HUMANENC1_HUMANBioGRID19424503 details
KEAP1_HUMANBRCA1_HUMANBioGRID22331464 details
KEAP1_HUMANULK1_HUMANBioGRID30907226 details
KEAP1_HUMANRMP_HUMANBioGRID31541481 details
KEAP1_HUMANEGLN1_HUMANBioGRID31763849 details
KEAP1_HUMANCYBP_HUMANIntAct25036637 details
KEAP1_HUMANPTG3L_HUMANIntAct25036637 details
KEAP1_HUMANBCL2_HUMANBioGRID30126895 details
KEAP1_HUMANPSMD2_HUMANBioGRID30126895 details
KEAP1_HUMANFXL17_HUMANBioGRID30190310 details
KEAP1_HUMANSESN2_HUMANBioGRID, IntAct23274085 details
KEAP1_HUMANIKKA_HUMANBioGRID, IntAct20600852 30500824 details
KEAP1_HUMANAASD1_HUMANIntAct25036637 details
KEAP1_HUMANNBR1_HUMANBioGRID30126895 details
KEAP1_HUMANNEST_HUMANBioGRID31695040 details
KEAP1_HUMANDDIT3_HUMANBioGRID23213463 details
KEAP1_HUMANU17L2_HUMANBioGRID30778200 details
KEAP1_HUMANCDK20_HUMANBioGRID28534518 details
KEAP1_HUMANG3P_HUMANBioGRID31491600 details
KEAP1_HUMANEP300_HUMANBioGRID32057361 details