Entity Details

Primary name GRM2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14416
EntryNameGRM2_HUMAN
FullNameMetabotropic glutamate receptor 2
TaxID9606
Evidenceevidence at protein level
Length872
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesGRM2

GO terms

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GOName
GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity
GO:0001641 group II metabotropic glutamate receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0005246 calcium channel regulator activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007216 G protein-coupled glutamate receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0008066 glutamate receptor activity
GO:0010467 gene expression
GO:0014047 glutamate secretion
GO:0014048 regulation of glutamate secretion
GO:0014059 regulation of dopamine secretion
GO:0030424 axon
GO:0030425 dendrite
GO:0035095 behavioral response to nicotine
GO:0042220 response to cocaine
GO:0042734 presynaptic membrane
GO:0051896 regulation of protein kinase B signaling
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0090461 glutamate homeostasis
GO:0097110 scaffold protein binding
GO:0097449 astrocyte projection
GO:0099055 integral component of postsynaptic membrane
GO:2001023 regulation of response to drug

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection

Domains

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DomainNameCategoryType
IPR000162 GPCR, family 3, metabotropic glutamate receptorFamilyFamily
IPR000337 GPCR, family 3FamilyFamily
IPR001458 GPCR, family 3, metabotropic glutamate receptor 2FamilyFamily
IPR001828 Receptor, ligand binding regionDomainDomain
IPR011500 GPCR, family 3, nine cysteines domainDomainDomain
IPR017978 GPCR family 3, C-terminalDomainDomain
IPR017979 GPCR, family 3, conserved siteSiteConserved site
IPR028082 Periplasmic binding protein-like IFamilyHomologous superfamily
IPR038550 GPCR, family 3, nine cysteines domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB05096 LY2140023Drugbanksmall molecule

Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
GRM2_HUMANNADL2_HUMANBioGRID, IntAct25416956 details
GRM2_HUMANUBQL1_HUMANBioGRID, IntAct25416956 details
GRM2_HUMANPDZ1I_HUMANBioGRID, IntAct32296183 details
GRM2_HUMANCC107_HUMANBioGRID, IntAct32296183 details
GRM2_HUMANACBD5_HUMANBioGRID, IntAct32296183 details
GRM2_HUMANEMC5_HUMANBioGRID, IntAct32296183 details
GRM2_HUMANCLD9_HUMANBioGRID, IntAct32296183 details
GRM2_HUMANSTOM_HUMANBioGRID, IntAct32296183 details
GRM2_HUMANZNT8_HUMANBioGRID, IntAct32296183 details
GRM2_HUMANCPLX4_HUMANBioGRID, IntAct32296183 details
GRM2_HUMANSAR1A_HUMANBioGRID, IntAct32296183 details
GRM2_HUMANMF14B_HUMANBioGRID, IntAct32296183 details
GRM2_HUMANAQP6_HUMANBioGRID, IntAct32296183 details
GRM2_HUMANBIK_HUMANBioGRID, IntAct32296183 details
GRM2_HUMANS38A1_HUMANBioGRID, IntAct32296183 details
GRM2_HUMANTM237_HUMANBioGRID, IntAct32296183 details
GRM2_HUMANCLD2_HUMANBioGRID, IntAct32296183 details
GRM2_HUMANNB5R3_HUMANBioGRID, IntAct32296183 details
GRM2_HUMANTM130_HUMANBioGRID, IntAct32296183 details
GRM2_HUMANMGST3_HUMANBioGRID, IntAct32296183 details
GRM2_HUMANTM248_HUMANBioGRID, IntAct32296183 details
GRM2_HUMAN5HT2A_HUMANDIP18297054 details
GRM2_HUMANGRIP1_HUMANBioGRID11891216 details
GRM2_HUMANSDCB1_HUMANBioGRID11891216 details
GRM2_HUMANLMNA_HUMANBioGRID24623722 details
GRM2_HUMANTSN18_HUMANBioGRID32296183 details
GRM2_HUMANNHRF1_HUMANBioGRID28392297 details
GRM2_HUMANNHRF2_HUMANBioGRID28392297 details
GRM2_HUMANGRASP_HUMANHPRD11850456 details
GRM2_HUMANGNAQ_HUMANHPRD8863838 details
GRM2_HUMANRGS12_HUMANHPRD9651375 details
GRM2_HUMANGNA15_HUMANHPRD8863838 details