Entity Details

Primary name PDE3A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14432
EntryNamePDE3A_HUMAN
FullNamecGMP-inhibited 3',5'-cyclic phosphodiesterase A
TaxID9606
Evidenceevidence at protein level
Length1141
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesPDE3A

GO terms

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GOName
GO:0001556 oocyte maturation
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
GO:0005829 cytosol
GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0016021 integral component of membrane
GO:0019933 cAMP-mediated signaling
GO:0019934 cGMP-mediated signaling
GO:0040020 regulation of meiotic nuclear division
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0043116 negative regulation of vascular permeability
GO:0043117 positive regulation of vascular permeability
GO:0043951 negative regulation of cAMP-mediated signaling
GO:0046872 metal ion binding
GO:0060282 positive regulation of oocyte development
GO:0071321 cellular response to cGMP
GO:0071560 cellular response to transforming growth factor beta stimulus

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domainDomainDomain
IPR003607 HD/PDEase domainDomainDomain
IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved siteSiteConserved site
IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00201 CaffeineDrugbanksmall molecule
DB00235 MilrinoneDrugbanksmall molecule
DB00261 AnagrelideDrugbanksmall molecule
DB00277 TheophyllineDrugbanksmall molecule
DB00922 LevosimendanDrugbanksmall molecule
DB01166 CilostazolDrugbanksmall molecule
DB01223 AminophyllineDrugbanksmall molecule
DB01303 OxtriphyllineDrugbanksmall molecule
DB01427 AmrinoneDrugbanksmall molecule
DB04880 EnoximoneDrugbanksmall molecule
DB05266 IbudilastDrugbanksmall molecule
DB08811 TofisopamDrugbanksmall molecule
DB09283 TrapidilDrugbanksmall molecule