Entity Details

Primary name HLA-E
Entity type gene
Source Source Link

Details

PrimaryID3133
RefseqGene
SymbolHLA-E
Namemajor histocompatibility complex, class I, E
Chromosome6
Location6p22.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1991-10-04
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsHLAE_HUMAN

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001815 positive regulation of antibody-dependent cellular cytotoxicity
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0002250 adaptive immune response
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib
GO:0002477 antigen processing and presentation of exogenous peptide antigen via MHC class Ib
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0002519 natural killer cell tolerance induction
GO:0002639 positive regulation of immunoglobulin production
GO:0002715 regulation of natural killer cell mediated immunity
GO:0002717 positive regulation of natural killer cell mediated immunity
GO:0002729 positive regulation of natural killer cell cytokine production
GO:0005102 signaling receptor binding
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016032 viral process
GO:0019731 antibacterial humoral response
GO:0030670 phagocytic vesicle membrane
GO:0030881 beta-2-microglobulin binding
GO:0031901 early endosome membrane
GO:0032398 MHC class Ib protein complex
GO:0032736 positive regulation of interleukin-13 production
GO:0032753 positive regulation of interleukin-4 production
GO:0032759 positive regulation of TRAIL production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032819 positive regulation of natural killer cell proliferation
GO:0036037 CD8-positive, alpha-beta T cell activation
GO:0042270 protection from natural killer cell mediated cytotoxicity
GO:0042288 MHC class I protein binding
GO:0042605 peptide antigen binding
GO:0042608 T cell receptor binding
GO:0042612 MHC class I protein complex
GO:0045087 innate immune response
GO:0045953 negative regulation of natural killer cell mediated cytotoxicity
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0046703 natural killer cell lectin-like receptor binding
GO:0050776 regulation of immune response
GO:0050830 defense response to Gram-positive bacterium
GO:0055038 recycling endosome membrane
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0070062 extracellular exosome
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation
GO:2001187 positive regulation of CD8-positive, alpha-beta T cell activation

Diseases

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Interactions

58 interactions

InteractorPartnerSourcesPublicationsLink
HLA-EPPP1R16AHPRD, IntAct16169070 details
HLA-ETRAPPC2BioGRID, IntAct23414517 details
HLA-EF2RL1BioGRID, MINT28298427 details
HLA-EKLRD1BioGRID, HPRD14734748 9486650 9815261 9886400 details
HLA-ECALRBioGRID15383281 9427624 details
HLA-EKLRC1HPRD, IntAct18083576 9486650 details
HLA-EKLRC2HPRD, IntAct18083576 9103421 9486650 details
HLA-EHLA-FBioGRID, IntAct20483783 26186194 28514442 details
HLA-EB2MBioGRID, HPRD, IntAct10064069 18332182 9605335 details
HLA-ETAP2BioGRID9427624 details
HLA-EHLA-EHPRD9605335 details
HLA-ECD8AHPRD10809759 details
HLA-EGALNT12BioGRID, IntAct26186194 28514442 details
HLA-EPLXNA3BioGRID, IntAct26186194 28514442 details
HLA-EATP23BioGRID, IntAct26186194 28514442 details
HLA-EBACE2BioGRID, IntAct26186194 28514442 details
HLA-EEIF2AK3BioGRID, IntAct26186194 28514442 details
HLA-ECNNM1BioGRID, IntAct26186194 28514442 details
HLA-ECNTNAP3BioGRID, IntAct26186194 28514442 details
HLA-EATF6BBioGRID, IntAct26186194 28514442 details
HLA-ELRIG1BioGRID, IntAct28514442 details
HLA-ETCTN2BioGRID, IntAct26186194 28514442 details
HLA-EPBXIP1BioGRID, IntAct26186194 28514442 details
HLA-EMR1BioGRID, IntAct26186194 28514442 details
HLA-EPTCD2BioGRID, IntAct26186194 28514442 details
HLA-EMETTL13BioGRID, IntAct26186194 28514442 details
HLA-EWDFY3BioGRID, IntAct26186194 28514442 details
HLA-ELRRC24BioGRID, IntAct28514442 details
HLA-EGAS6BioGRID, IntAct26186194 28514442 details
HLA-EASPHBioGRID, IntAct26186194 28514442 details
HLA-EMGAT5BioGRID, IntAct26186194 28514442 details
HLA-EFCGRTBioGRID, IntAct26186194 28514442 details
HLA-EEPHB4BioGRID, IntAct26186194 28514442 details
HLA-ENEK4BioGRID, IntAct26186194 28514442 details
HLA-EMAN2A2BioGRID, IntAct26186194 28514442 details
HLA-EITGA6BioGRID, IntAct26186194 28514442 details
HLA-EATF6BioGRID, IntAct26186194 28514442 details
HLA-EHLA-ABioGRID, IntAct26186194 28514442 details
HLA-EECEL1BioGRID, IntAct26186194 28514442 details
HLA-ERTL8CBioGRID, IntAct26186194 28514442 details
HLA-EHLA-BBioGRID, IntAct26186194 28514442 details
HLA-EHLA-GBioGRID, IntAct28514442 details
HLA-EHLA-CBioGRID, IntAct26186194 28514442 details
HLA-ENDST2BioGRID26186194 details
HLA-ENDST1BioGRID26186194 details
HLA-EARFGEF2BioGRID26186194 details
HLA-EHLA-DPB1BioGRID26186194 details
HLA-EABCA3BioGRID26186194 details
HLA-EPLXNB2BioGRID26186194 details
HLA-ETMEM131BioGRID26186194 details
HLA-EFAM189BBioGRID26186194 details
HLA-EKCNJ8BioGRID26186194 details
HLA-EMADDBioGRID26186194 details
HLA-EEDEM2BioGRID26186194 details
HLA-EHERC2BioGRID25476789 details
HLA-ECFTRBioGRID26618866 details
HLA-EPHBBioGRID27025967 details
HLA-EDDX58BioGRID32513696 details