Entity Details

Primary name S39AE_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15043
EntryNameS39AE_HUMAN
FullNameMetal cation symporter ZIP14
TaxID9606
Evidenceevidence at protein level
Length492
SequenceStatuscomplete
DateCreated2007-12-04
DateModified2021-06-02

Ontological Relatives

GenesSLC39A14

GO terms

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GOName
GO:0002062 chondrocyte differentiation
GO:0005381 iron ion transmembrane transporter activity
GO:0005384 manganese ion transmembrane transporter activity
GO:0005385 zinc ion transmembrane transporter activity
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006094 gluconeogenesis
GO:0006882 cellular zinc ion homeostasis
GO:0008286 insulin receptor signaling pathway
GO:0010817 regulation of hormone levels
GO:0015086 cadmium ion transmembrane transporter activity
GO:0015093 ferrous iron transmembrane transporter activity
GO:0015296 anion:cation symporter activity
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0031901 early endosome membrane
GO:0031902 late endosome membrane
GO:0032869 cellular response to insulin stimulus
GO:0033212 iron import into cell
GO:0034755 iron ion transmembrane transport
GO:0045745 positive regulation of G protein-coupled receptor signaling pathway
GO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity
GO:0055071 manganese ion homeostasis
GO:0070574 cadmium ion transmembrane transport
GO:0071333 cellular response to glucose stimulus
GO:0071421 manganese ion transmembrane transport
GO:0071577 zinc ion transmembrane transport
GO:0071578 zinc ion import across plasma membrane
GO:0098739 import across plasma membrane

Subcellular Location

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Subcellular Location
Apical cell membrane
Basolateral cell membrane
Cell membrane
Early endosome membrane
Late endosome membrane
Lysosome membrane

Domains

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DomainNameCategoryType
IPR003689 Zinc/iron permeaseFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
S39AE_HUMANSEPT3_HUMANBioGRID, IntAct32296183 details
S39AE_HUMANLZTS2_HUMANBioGRID, IntAct32296183 details
S39AE_HUMANBKRB1_HUMANBioGRID, MINT28298427 details