Entity Details

Primary name MC4R
Entity type gene
Source Source Link

Details

PrimaryID4160
RefseqGeneNG_016441
SymbolMC4R
Namemelanocortin 4 receptor
Chromosome18
Location18q21.32
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-05-13
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsMC4R_HUMAN

GO terms

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GOName
GO:0002024 diet induced thermogenesis
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004930 G protein-coupled receptor activity
GO:0004977 melanocortin receptor activity
GO:0004980 melanocyte-stimulating hormone receptor activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0006112 energy reserve metabolic process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007631 feeding behavior
GO:0016021 integral component of membrane
GO:0017046 peptide hormone binding
GO:0019222 regulation of metabolic process
GO:0031625 ubiquitin protein ligase binding
GO:0042923 neuropeptide binding
GO:0045780 positive regulation of bone resorption
GO:2000252 negative regulation of feeding behavior
GO:2000821 regulation of grooming behavior

Diseases

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Disease IDSourceNameDescription
601665 OMIMObesity (OBESITY)A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. The disease is caused by variants affecting the gene represented in this entry.