Entity Details

Primary name NOS1
Entity type gene
Source Source Link

Details

PrimaryID4842
RefseqGeneNG_011991
SymbolNOS1
Namenitric oxide synthase 1
Chromosome12
Location12q24.22
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1993-06-15
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsNOS1_HUMAN

GO terms

Show/Hide Table
GOName
GO:0001666 response to hypoxia
GO:0001917 photoreceptor inner segment
GO:0002028 regulation of sodium ion transport
GO:0004517 nitric-oxide synthase activity
GO:0005516 calmodulin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0006527 arginine catabolic process
GO:0006809 nitric oxide biosynthetic process
GO:0006936 muscle contraction
GO:0006941 striated muscle contraction
GO:0007263 nitric oxide mediated signal transduction
GO:0007520 myoblast fusion
GO:0009408 response to heat
GO:0009725 response to hormone
GO:0010181 FMN binding
GO:0010523 negative regulation of calcium ion transport into cytosol
GO:0012506 vesicle membrane
GO:0014069 postsynaptic density
GO:0016491 oxidoreductase activity
GO:0016529 sarcoplasmic reticulum
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0017080 sodium channel regulator activity
GO:0018119 peptidyl-cysteine S-nitrosylation
GO:0020037 heme binding
GO:0031284 positive regulation of guanylate cyclase activity
GO:0032496 response to lipopolysaccharide
GO:0032991 protein-containing complex
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033555 multicellular organismal response to stress
GO:0034617 tetrahydrobiopterin binding
GO:0034618 arginine binding
GO:0035066 positive regulation of histone acetylation
GO:0042136 neurotransmitter biosynthetic process
GO:0042311 vasodilation
GO:0042383 sarcolemma
GO:0042738 exogenous drug catabolic process
GO:0043197 dendritic spine
GO:0043267 negative regulation of potassium ion transport
GO:0044325 transmembrane transporter binding
GO:0045121 membrane raft
GO:0045202 synapse
GO:0045454 cell redox homeostasis
GO:0045776 negative regulation of blood pressure
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046870 cadmium ion binding
GO:0048306 calcium-dependent protein binding
GO:0048471 perinuclear region of cytoplasm
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
GO:0051346 negative regulation of hydrolase activity
GO:0051612 negative regulation of serotonin uptake
GO:0051926 negative regulation of calcium ion transport
GO:0055117 regulation of cardiac muscle contraction
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
GO:0071363 cellular response to growth factor stimulus
GO:0071944 cell periphery
GO:0097110 scaffold protein binding
GO:0098735 positive regulation of the force of heart contraction
GO:0098924 retrograde trans-synaptic signaling by nitric oxide
GO:1902307 positive regulation of sodium ion transmembrane transport
GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
GO:1903779 regulation of cardiac conduction

Diseases

Show/Hide Table

Interactions

38 interactions

InteractorPartnerSourcesPublicationsLink
NOS1VAC14HPRD, MINT17161399 details
NOS1ZDHHC23BioGRID, HPRD15105416 details
NOS1RASD1BioGRID, HPRD11086993 details
NOS1SYN1BioGRID11867766 details
NOS1SNTA1BioGRID, HPRD10221915 11747091 9412493 details
NOS1NOS1APBioGRID, HPRD9459447 details
NOS1DLG4BioGRID, HPRD10488080 8625413 9459447 details
NOS1DLG2BioGRID, HPRD8625413 8922396 details
NOS1STUB1BioGRID15466472 20729196 23109339 32591478 details
NOS1PRKD1BioGRID24740233 details
NOS1NOS1BioGRID8995432 details
NOS1SOX2BioGRID26607632 details
NOS1DYNLL1HPRD8864115 9808772 9837926 details
NOS1GRIN2ADIP17360663 details
NOS1BDKRB2BioGRID, HPRD10681501 details
NOS1PTPN6BioGRID, HPRD11511520 details
NOS1HSPA4BioGRID15466472 details
NOS1DMDBioGRID7545544 details
NOS1PRNPBioGRID11032878 details
NOS1HSP90AA1HPRD11284722 9880522 details
NOS1PFKMHPRD10187848 details
NOS1ATP2B4HPRD11591728 details
NOS1ADRA1AHPRD12184796 details
NOS1ADRA1DHPRD12184796 details
NOS1ADRA1BHPRD12184796 details
NOS1ADRB1HPRD12184796 details
NOS1ADRB2HPRD12184796 details
NOS1HMOX1HPRD11849436 details
NOS1PRKCAHPRD10400690 10874031 12630910 1375933 details
NOS1ARG1HPRD11849441 details
NOS1CAV3HPRD9353265 details
NOS1PRKACAHPRD10400690 10874031 12630910 1375933 details
NOS1PTPRNHPRD11043403 details
NOS1CTBP1HPRD11590170 details
NOS1CAMK1HPRD10400690 10874031 12630910 1375933 15251453 details
NOS1CAMK4HPRD10400690 10874031 12630910 1375933 details
NOS1NOSIPHPRD15548660 details
NOS1CKAP4BioGRID, IntAct30021884 details