Entity Details

Primary name NTRK3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16288
EntryNameNTRK3_HUMAN
FullNameNT-3 growth factor receptor
TaxID9606
Evidenceevidence at protein level
Length839
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesNTRK3

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001933 negative regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0002039 p53 binding
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005030 neurotrophin receptor activity
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0007507 heart development
GO:0008284 positive regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0010863 positive regulation of phospholipase C activity
GO:0010976 positive regulation of neuron projection development
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030154 cell differentiation
GO:0030335 positive regulation of cell migration
GO:0030424 axon
GO:0032148 activation of protein kinase B activity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033674 positive regulation of kinase activity
GO:0043121 neurotrophin binding
GO:0043235 receptor complex
GO:0043410 positive regulation of MAPK cascade
GO:0050927 positive regulation of positive chemotaxis
GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway
GO:0051896 regulation of protein kinase B signaling
GO:0090630 activation of GTPase activity
GO:1990090 cellular response to nerve growth factor stimulus
GO:2000251 positive regulation of actin cytoskeleton reorganization

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR000372 Leucine-rich repeat N-terminal domainDomainDomain
IPR000483 Cysteine-rich flanking region, C-terminalDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001611 Leucine-rich repeatRepeatRepeat
IPR002011 Tyrosine-protein kinase, receptor class II, conserved siteSiteConserved site
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013098 Immunoglobulin I-setDomainDomain
IPR013151 ImmunoglobulinDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020446 Tyrosine-protein kinase, neurotrophic receptor, type 3FamilyFamily
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR020777 Tyrosine-protein kinase, neurotrophic receptorFamilyFamily
IPR031635 Tyrosine-protein kinase receptor NTRK, C2-Ig-like domainDomainDomain
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB11986 EntrectinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB14723 LarotrectinibDrugbanksmall molecule
DB15822 PralsetinibDrugbanksmall molecule

Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
NTRK3_HUMANPTN1_HUMANBioGRID, HPRD, MINT12237455 details
NTRK3_HUMANIRAK3_HUMANBioGRID, IntAct21988832 details
NTRK3_HUMANSORT_HUMANbhf-ucl, BioGRID21102451 details
NTRK3_HUMAN5HT2A_HUMANDIP, HPRD16537434 details
NTRK3_HUMANDOK6_HUMANBioGRID, IntAct20565848 details
NTRK3_HUMANNTF3_HUMANBioGRID, HPRD8621424 9488719 9973222 details
NTRK3_HUMANFRS2_HUMANBioGRID10092678 details
NTRK3_HUMANSHC1_HUMANBioGRID, HPRD10092678 7657612 details
NTRK3_HUMANPLCG1_HUMANBioGRID, HPRD10092678 7657612 details
NTRK3_HUMANA4_HUMANBioGRID21832049 details
NTRK3_HUMANERBB2_HUMANBioGRID30898150 details
NTRK3_HUMANNELFB_HUMANBioGRID24034695 details
NTRK3_HUMANHEY1_HUMANBioGRID24034695 details
NTRK3_HUMANWDR13_HUMANBioGRID24034695 details
NTRK3_HUMANIMA3_HUMANBioGRID24034695 details
NTRK3_HUMANNSD1_HUMANBioGRID24034695 details
NTRK3_HUMANBEX3_HUMANHPRD10764727 details
NTRK3_HUMANDOK5_HUMANHPRD16647839 details
NTRK3_HUMANSHC2_HUMANHPRD12006576 details
NTRK3_HUMANHS90B_HUMANIntAct22939624 details
NTRK3_HUMANPTPRS_HUMANBioGRID, IntAct25624497 28514442 details
NTRK3_HUMANSQSTM_HUMANBioGRID, HPRD12471037 details
NTRK3_HUMANHS90A_HUMANBioGRID22939624 details
NTRK3_HUMANACK1_HUMANBioGRID23598414 details
NTRK3_HUMANNFIP1_HUMANBioGRID29911254 details
NTRK3_HUMANMK01_HUMANHPRD11205744 9973222 details
NTRK3_HUMANIRAK1_HUMANHPRD12034707 details
NTRK3_HUMANDYL1_HUMANHPRD11157096 details
NTRK3_HUMANMK03_HUMANHPRD11205744 details
NTRK3_HUMANKDIS_HUMANHPRD15167895 details
NTRK3_HUMANJUN_HUMANHPRD9973222 details
NTRK3_HUMANRGRF1_HUMANHPRD15513915 details
NTRK3_HUMANTNR16_HUMANHPRD9927421 details