Entity Details

Primary name CRY1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16526
EntryNameCRY1_HUMAN
FullNameCryptochrome-1
TaxID9606
Evidenceevidence at protein level
Length586
SequenceStatuscomplete
DateCreated2006-11-28
DateModified2021-06-02

Ontological Relatives

GenesCRY1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0006094 gluconeogenesis
GO:0006975 DNA damage induced protein phosphorylation
GO:0007623 circadian rhythm
GO:0009416 response to light stimulus
GO:0009785 blue light signaling pathway
GO:0009882 blue light photoreceptor activity
GO:0014823 response to activity
GO:0018298 protein-chromophore linkage
GO:0019901 protein kinase binding
GO:0019902 phosphatase binding
GO:0019915 lipid storage
GO:0031397 negative regulation of protein ubiquitination
GO:0031398 positive regulation of protein ubiquitination
GO:0032868 response to insulin
GO:0032922 circadian regulation of gene expression
GO:0033762 response to glucagon
GO:0042593 glucose homeostasis
GO:0042752 regulation of circadian rhythm
GO:0042754 negative regulation of circadian rhythm
GO:0042826 histone deacetylase binding
GO:0043153 entrainment of circadian clock by photoperiod
GO:0045721 negative regulation of gluconeogenesis
GO:0045744 negative regulation of G protein-coupled receptor signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0070888 E-box binding
GO:0071949 FAD binding
GO:2000001 regulation of DNA damage checkpoint
GO:2000323 negative regulation of glucocorticoid receptor signaling pathway
GO:2000850 negative regulation of glucocorticoid secretion

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR005101 Cryptochrome/DNA photolyase, FAD-binding domainDomainDomain
IPR006050 DNA photolyase, N-terminalDomainDomain
IPR014729 Rossmann-like alpha/beta/alpha sandwich foldFamilyHomologous superfamily
IPR036134 Cryptochrome/DNA photolyase, FAD-binding domain-like superfamilyFamilyHomologous superfamily
IPR036155 Cryptochrome/photolyase, N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

34 interactions

InteractorPartnerSourcesPublicationsLink
CRY1_HUMANPLS1_HUMANBioGRID, HPRD, IntAct16189514 21988832 details
CRY1_HUMANCBLB_HUMANBioGRID, HPRD, IntAct16189514 details
CRY1_HUMANMDFI_HUMANBioGRID, HPRD, IntAct16189514 details
CRY1_HUMANKR412_HUMANBioGRID, HPRD, IntAct16189514 details
CRY1_HUMANTRAF2_HUMANBioGRID, HPRD, IntAct16189514 details
CRY1_HUMANLTBP4_HUMANBioGRID, IntAct21988832 details
CRY1_HUMANSMD3_HUMANBioGRID, IntAct21988832 details
CRY1_HUMANGRN_HUMANBioGRID, IntAct21988832 details
CRY1_HUMANKC1E_HUMANBioGRID, HPRD, IntAct11875063 23455922 23555304 26496610 28514442 details
CRY1_HUMANFBXL3_HUMANBioGRID, IntAct17463251 24085301 25756610 26186194 27565346 28514442 details
CRY1_HUMANPER1_HUMANBioGRID, HPRD, IntAct10531061 12782655 23555304 25756610 26186194 28514442 details
CRY1_HUMANBMAL1_HUMANBioGRID, HPRD, IntAct10531061 23555304 25756610 28388406 details
CRY1_HUMANCLOCK_HUMANBioGRID, IntAct, MINT23555304 28388406 32538895 details
CRY1_HUMANPER2_HUMANBioGRID, HPRD10428031 10531061 11533252 23555304 25103245 25756610 27834218 30425162 details
CRY1_HUMANCRY1_HUMANBioGRID17073458 details
CRY1_HUMANUBP2_HUMANBioGRID22669941 details
CRY1_HUMANCSK2B_HUMANBioGRID23555304 26562092 details
CRY1_HUMANBHE41_HUMANBioGRID23555304 details
CRY1_HUMANNPAS2_HUMANBioGRID23555304 details
CRY1_HUMAN2A5E_HUMANBioGRID23555304 details
CRY1_HUMAN2AAB_HUMANBioGRID23555304 25756610 details
CRY1_HUMAN2A5D_HUMANBioGRID23555304 details
CRY1_HUMANNR1D2_HUMANBioGRID23555304 details
CRY1_HUMANUBP7_HUMANBioGRID25756610 details
CRY1_HUMANARI1_HUMANBioGRID27565346 details
CRY1_HUMANCSK21_HUMANBioGRID26562092 details
CRY1_HUMANANM5_HUMANBioGRID, IntAct23133559 25756610 details
CRY1_HUMANHNF4A_HUMANIntAct30530698 details
CRY1_HUMANFBW1A_HUMANBioGRID17463251 details
CRY1_HUMANFOXO1_HUMANBioGRID27412556 28790135 details
CRY1_HUMANDET1_HUMANBioGRID31155351 details
CRY1_HUMANMLXPL_HUMANBioGRID32246987 details
CRY1_HUMANTIM_HUMANHPRD10428031 details
CRY1_HUMANPER3_HUMANHPRD10428031 details