Entity Details

Primary name CALRL_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16602
EntryNameCALRL_HUMAN
FullNameCalcitonin gene-related peptide type 1 receptor
TaxID9606
Evidenceevidence at protein level
Length461
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesCALCRL

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001605 adrenomedullin receptor activity
GO:0001635 calcitonin gene-related peptide receptor activity
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004930 G protein-coupled receptor activity
GO:0004948 calcitonin receptor activity
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006816 calcium ion transport
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007507 heart development
GO:0008528 G protein-coupled peptide receptor activity
GO:0015031 protein transport
GO:0031623 receptor internalization
GO:0045986 negative regulation of smooth muscle contraction
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0071329 cellular response to sucrose stimulus
GO:1903143 adrenomedullin receptor complex
GO:1990406 CGRP receptor complex
GO:1990408 calcitonin gene-related peptide receptor signaling pathway
GO:1990409 adrenomedullin binding
GO:1990410 adrenomedullin receptor signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000832 GPCR, family 2, secretin-likeFamilyFamily
IPR001879 GPCR, family 2, extracellular hormone receptor domainDomainDomain
IPR003287 GPCR, family 2, calcitonin receptor familyFamilyFamily
IPR003289 GPCR, family 2, calcitonin gene-related peptide, type 1 receptorFamilyFamily
IPR017981 GPCR, family 2-likeDomainDomain
IPR017983 GPCR, family 2, secretin-like, conserved siteSiteConserved site
IPR036445 GPCR family 2, extracellular hormone receptor domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB04869 OlcegepantDrugbanksmall molecule
DB12228 TelcagepantDrugbanksmall molecule
DB12457 RimegepantDrugbanksmall molecule
DB14039 ErenumabDrugbankbiotech
DB15328 UbrogepantDrugbanksmall molecule
DB15688 VazegepantDrugbanksmall molecule