Entity Details

Primary name PRKCZ
Entity type gene
Source Source Link

Details

PrimaryID5590
RefseqGeneNG_029616
SymbolPRKCZ
Nameprotein kinase C zeta
Chromosome1
Location1p36.33
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1994-05-16
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsKPCZ_HUMAN

GO terms

Show/Hide Table
GOName
GO:0000226 microtubule cytoskeleton organization
GO:0001725 stress fiber
GO:0001954 positive regulation of cell-matrix adhesion
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004697 protein kinase C activity
GO:0004698 calcium-dependent protein kinase C activity
GO:0005524 ATP binding
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005923 bicellular tight junction
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007616 long-term memory
GO:0008284 positive regulation of cell population proliferation
GO:0014069 postsynaptic density
GO:0015459 potassium channel regulator activity
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0016363 nuclear matrix
GO:0016477 cell migration
GO:0018105 peptidyl-serine phosphorylation
GO:0019901 protein kinase binding
GO:0030010 establishment of cell polarity
GO:0030054 cell junction
GO:0031252 cell leading edge
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031584 activation of phospholipase D activity
GO:0031982 vesicle
GO:0032148 activation of protein kinase B activity
GO:0032733 positive regulation of interleukin-10 production
GO:0032736 positive regulation of interleukin-13 production
GO:0032753 positive regulation of interleukin-4 production
GO:0032754 positive regulation of interleukin-5 production
GO:0032869 cellular response to insulin stimulus
GO:0035556 intracellular signal transduction
GO:0035748 myelin sheath abaxonal region
GO:0043066 negative regulation of apoptotic process
GO:0043203 axon hillock
GO:0043274 phospholipase binding
GO:0043560 insulin receptor substrate binding
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0045179 apical cortex
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046872 metal ion binding
GO:0047496 vesicle transport along microtubule
GO:0048471 perinuclear region of cytoplasm
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051222 positive regulation of protein transport
GO:0051346 negative regulation of hydrolase activity
GO:0051899 membrane depolarization
GO:0060081 membrane hyperpolarization
GO:0060291 long-term synaptic potentiation
GO:0070062 extracellular exosome
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070528 protein kinase C signaling
GO:0071889 14-3-3 protein binding
GO:0072659 protein localization to plasma membrane
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
GO:0098978 glutamatergic synapse
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1990138 neuron projection extension
GO:2000463 positive regulation of excitatory postsynaptic potential
GO:2000553 positive regulation of T-helper 2 cell cytokine production

Diseases

Show/Hide Table

Interactions

277 interactions

InteractorPartnerSourcesPublicationsLink
PRKCZPARD6ABioGRID, HPRD, IntAct, MINT11260256 12813044 14676191 15254234 16189514 17057644 17335965 17350623 25852190 27143478 28514442 details
PRKCZPARD6BBioGRID, HPRD, IntAct11260256 12887891 14676191 25852190 26186194 27107012 28514442 29491746 31980649 32296183 details
PRKCZPARD6GBioGRID, HPRD, IntAct, MINT11260256 14676191 17057644 25852190 28514442 31980649 details
PRKCZRELABioGRID, HPRD, MINT11684013 12881425 21131967 details
PRKCZNUMBBioGRID, HPRD, MINT17203073 details
PRKCZPRKCQIntAct17588663 details
PRKCZAKT1BioGRID, HPRD, MINT10085094 11723139 14560023 18353613 18650932 details
PRKCZGABARAPBioGRID, IntAct20562859 31857374 details
PRKCZHSP90AA1BioGRID, IntAct20936779 22939624 29491746 details
PRKCZCCDC115BioGRID, MINT21900206 details
PRKCZDENND5ABioGRID, MINT21900206 details
PRKCZNMT2BioGRID, MINT21900206 details
PRKCZUTP14ABioGRID, MINT21900206 details
PRKCZYWHABBioGRID, HPRD, MINT10620507 21900206 details
PRKCZZNF71BioGRID, MINT21900206 details
PRKCZC1QBPBioGRID, HPRD, IntAct, UniProt10831594 23402259 25852190 29491746 31980649 details
PRKCZAKT3BioGRID, HPRD, IntAct12162751 25241761 9305920 9512493 details
PRKCZEGFRBioGRID, IntAct24658140 25402006 31980649 details
PRKCZSQSTM1BioGRID, HPRD, IntAct10356400 10747026 11755531 12813044 12887891 15143057 15870274 20974803 20979579 23023376 25852190 26187466 27143478 28514442 29491746 31980649 32354117 34079125 9566925 details
PRKCZNCF1BioGRID, HPRD, IntAct11145703 12056906 27040869 8089108 details
PRKCZWWC1BioGRID, HPRD, IntAct15081397 28514442 31980649 details
PRKCZPDPK1BioGRID, HPRD10357815 10764742 11222751 11781095 14500673 9748166 details
PRKCZADAP1BioGRID, HPRD12893243 details
PRKCZYWHAZBioGRID10620507 12893243 29491746 details
PRKCZNFATC2BioGRID, HPRD12021260 details
PRKCZDAPK3BioGRID, HPRD12242277 details
PRKCZNCLBioGRID, HPRD9388266 details
PRKCZYWHAQBioGRID10620507 details
PRKCZRAF1BioGRID, HPRD10620507 details
PRKCZTIAM1BioGRID10212259 details
PRKCZFEZ1BioGRID, HPRD9971736 details
PRKCZPAWRBioGRID, HPRD11755531 8797824 details
PRKCZMAP2K5BioGRID11158308 details
PRKCZSP1BioGRID16943418 18258854 details
PRKCZSTUB1BioGRID21911421 details
PRKCZPIAS4BioGRID21624955 27162139 details
PRKCZPRKCZBioGRID, HPRD17639074 21624955 29491746 31980649 7588787 8375396 9748166 details
PRKCZMBPBioGRID, HPRD10383403 17639074 21315177 details
PRKCZNCOA3BioGRID18313384 details
PRKCZLRRK2BioGRID20949042 details
PRKCZH1-1BioGRID12056906 details
PRKCZPPP1R14ABioGRID, HPRD15003508 details
PRKCZMARCKSBioGRID7588787 details
PRKCZH1-5BioGRID8663071 details
PRKCZMAPK7BioGRID20538799 details
PRKCZBLVRABioGRID17639074 details
PRKCZHDAC6BioGRID25860570 details
PRKCZMAPTBioGRID11104762 details
PRKCZMAP1LC3BBioGRID31857374 details
PRKCZFRS2HPRD10383403 details
PRKCZPRKCIBioGRID, IntAct, MINT11260256 24375676 25852190 28514442 29491746 31980649 details
PRKCZF11RBioGRID, IntAct, MINT17057644 25241761 details
PRKCZVHLBioGRID, MINT10491320 17101696 17350623 details
PRKCZHSP90AB1BioGRID, IntAct22939624 29491746 details
PRKCZGSK3BBioGRID, HPRD, IntAct11481324 25241761 details
PRKCZGRM5BioGRID, HPRD, IntAct15894802 25241761 details
PRKCZBCL10IntAct25011391 details
PRKCZTRIM41BioGRID, IntAct17893151 28514442 details
PRKCZAGERIntAct21829704 details
PRKCZNPM1BioGRID, IntAct23402259 29491746 31980649 details
PRKCZCD44BioGRID, IntAct22610405 31980649 details
PRKCZCSNK2BBioGRID, HPRD, IntAct10764587 29491746 31980649 details
PRKCZPARD3BioGRID, IntAct12459187 31980649 details
PRKCZECT2BioGRID15254234 details
PRKCZFEZ2BioGRID, HPRD14697253 details
PRKCZIRAK1BioGRID, HPRD11937546 details
PRKCZTRAF6BioGRID, HPRD10747026 details
PRKCZGRB14BioGRID, HPRD12242277 details
PRKCZKRT10BioGRID, HPRD11585925 details
PRKCZRPS6KB1BioGRID16931574 details
PRKCZYWHAGBioGRID10620507 details
PRKCZYWHAHBioGRID10620507 details
PRKCZFADDBioGRID, HPRD11739185 details
PRKCZSRCBioGRID, HPRD10527887 details
PRKCZMSH6BioGRID15808853 details
PRKCZMSH2BioGRID15808853 details
PRKCZTLR4BioGRID21911421 details
PRKCZTLR9BioGRID21911421 details
PRKCZESR1BioGRID18313384 details
PRKCZAJUBABioGRID15870274 details
PRKCZCFL1BioGRID23402259 29491746 details
PRKCZAKT2BioGRID18353613 details
PRKCZABL1BioGRID16631755 details
PRKCZAPPL1BioGRID26583432 details
PRKCZRNF146BioGRID27521426 details
PRKCZPPP2CABioGRID29491746 details
PRKCZJAK1BioGRID, HPRD15526032 29491746 details
PRKCZPRKCABioGRID, HPRD10339425 12162751 31980649 8856079 details
PRKCZRIPK1BioGRID32354117 details
PRKCZUSP20BioGRID32354117 details
PRKCZPRKCDHPRD11381116 12162751 details
PRKCZCASP3HPRD11016947 details
PRKCZIKBKBHPRD10022904 10195894 10779355 9689078 details
PRKCZIRS4HPRD12774026 details
PRKCZPEBP1HPRD12551925 14654844 details
PRKCZADCY5HPRD8206971 details
PRKCZPRG2HPRD10357815 11222751 14500673 9748166 details
PRKCZAFAP1HPRD12134071 details
PRKCZPDLIM7HPRD8940095 details
PRKCZHABP4HPRD14699138 details
PRKCZBTKHPRD11788586 7522330 details
PRKCZPPP3CAHPRD12021260 details
PRKCZCDC42HPRD10733591 details
PRKCZGLRX3HPRD10636891 details
PRKCZCHATHPRD15381704 details
PRKCZMAPK3HPRD15721486 details
PRKCZMAPK1HPRD15721486 details
PRKCZHRASHPRD15721486 details
PRKCZIL4RHPRD15526032 details
PRKCZRHOAHPRD15210811 details
PRKCZMAP2K1HPRD11535599 details
PRKCZSTAT6HPRD15526032 details
PRKCZGSK3AHPRD11481324 details
PRKCZFYNHPRD8621384 details
PRKCZCASP9HPRD16287866 details
PRKCZCASP6HPRD11016947 details
PRKCZCASP8HPRD11016947 details
PRKCZCASP7HPRD11016947 details
PRKCZSLC39A1HPRD10477520 details
PRKCZIRS1HPRD11063744 details
PRKCZPSEN1HPRD14576165 details
PRKCZLLGL1BioGRID, IntAct24366813 25852190 28514442 29491746 31980649 details
PRKCZRICTORMINT24375676 details
PRKCZLLGL2BioGRID, IntAct24366813 25852190 28514442 29491746 31980649 details
PRKCZDYNLL1BioGRID, IntAct25852190 details
PRKCZPAK1IntAct23175184 unassigned1271 details
PRKCZRALGDSIntAct23175184 unassigned1271 details
PRKCZCDC42BPBBioGRID, IntAct28514442 details
PRKCZNIPSNAP2BioGRID, IntAct28514442 31980649 details
PRKCZPRKAR1ABioGRID, IntAct31980649 details
PRKCZHUWE1BioGRID, IntAct31980649 details
PRKCZRPUSD4BioGRID, IntAct31980649 details
PRKCZIPO5BioGRID, IntAct31980649 details
PRKCZPOLRMTBioGRID, IntAct31980649 details
PRKCZDNAJA2BioGRID, IntAct31980649 details
PRKCZNPM3BioGRID, IntAct29491746 31980649 details
PRKCZFARP2BioGRID, IntAct31980649 details
PRKCZAP2A2BioGRID, IntAct31980649 details
PRKCZBAG2BioGRID, IntAct29491746 31980649 details
PRKCZAIFM1BioGRID, IntAct31980649 details
PRKCZADH1CBioGRID, IntAct31980649 details
PRKCZHSPB1BioGRID, IntAct29491746 31980649 details
PRKCZSLC25A5BioGRID, IntAct29491746 31980649 details
PRKCZTUBBBioGRID, IntAct31980649 details
PRKCZHSPA8BioGRID, IntAct31980649 details
PRKCZSLC25A6BioGRID, IntAct31980649 details
PRKCZSLC25A4BioGRID, IntAct31980649 details
PRKCZHSPA6BioGRID, IntAct31980649 details
PRKCZFBLBioGRID, IntAct31980649 details
PRKCZPRKACBBioGRID, IntAct31980649 details
PRKCZCADBioGRID, IntAct31980649 details
PRKCZPOLD1BioGRID, IntAct31980649 details
PRKCZDNAJA1BioGRID, IntAct31980649 details
PRKCZHADHABioGRID, IntAct31980649 details
PRKCZCPT1ABioGRID, IntAct31980649 details
PRKCZMRPL12BioGRID, IntAct29491746 31980649 details
PRKCZHADHBBioGRID, IntAct31980649 details
PRKCZNAP1L1BioGRID, IntAct29491746 31980649 details
PRKCZPSME3BioGRID, IntAct31980649 details
PRKCZTUBB4BBioGRID, IntAct31980649 details
PRKCZCSNK2A1BioGRID, IntAct31980649 details
PRKCZCSNK2A3BioGRID, IntAct31980649 details
PRKCZPKD1IntAct31980649 details
PRKCZSLC25A3BioGRID, IntAct29491746 31980649 details
PRKCZASPHBioGRID, IntAct31980649 details
PRKCZTRIM26BioGRID, IntAct31980649 details
PRKCZTRIM28BioGRID, IntAct31980649 details
PRKCZKEAP1BioGRID, IntAct29491746 31980649 details
PRKCZRCN2BioGRID, IntAct31980649 details
PRKCZNEDD8BioGRID, IntAct31980649 details
PRKCZDDB1BioGRID, IntAct31980649 details
PRKCZCDC37BioGRID, IntAct29491746 31980649 details
PRKCZSLC35G1BioGRID, IntAct31980649 details
PRKCZTIMM50BioGRID, IntAct31980649 details
PRKCZAP3S1BioGRID, IntAct31980649 details
PRKCZGLG1BioGRID, IntAct31980649 details
PRKCZAP2M1BioGRID, IntAct31980649 details
PRKCZMRPL53BioGRID, IntAct29491746 31980649 details
PRKCZNAP1L4BioGRID, IntAct31980649 details
PRKCZNIPSNAP1BioGRID, IntAct29491746 31980649 details
PRKCZTUBB6BioGRID, IntAct29491746 31980649 details
PRKCZDDA1BioGRID, IntAct31980649 details
PRKCZUBE2OBioGRID, IntAct31980649 details
PRKCZEPB41L4BBioGRID, IntAct31980649 details
PRKCZWDR26BioGRID, IntAct29491746 31980649 details
PRKCZITSN2BioGRID, IntAct31980649 details
PRKCZCAMSAP3BioGRID, IntAct31980649 details
PRKCZMRPS2BioGRID, IntAct31980649 details
PRKCZNOC2LBioGRID, IntAct31980649 details
PRKCZDCAF1BioGRID, IntAct31980649 details
PRKCZGTF3C5BioGRID, IntAct31980649 details
PRKCZPRKACAIntAct31980649 details
PRKCZCALUBioGRID, IntAct31980649 details
PRKCZFAT1BioGRID, IntAct31980649 details
PRKCZPPFIBP1BioGRID, IntAct31980649 details
PRKCZCKAP4BioGRID25852190 details
PRKCZAPI5BioGRID27684187 details
PRKCZHSPA5BioGRID29491746 details
PRKCZKCTD5BioGRID29491746 details
PRKCZPPP1CCBioGRID29491746 details
PRKCZCAVIN2BioGRID29491746 details
PRKCZCHCHD2BioGRID29491746 details
PRKCZRPLP1BioGRID29491746 details
PRKCZMAP1BBioGRID29491746 details
PRKCZPRDX4BioGRID29491746 details
PRKCZEIF3EBioGRID29491746 details
PRKCZMRPL49BioGRID29491746 details
PRKCZTUBB3BioGRID29491746 details
PRKCZRPS12BioGRID29491746 details
PRKCZGID8BioGRID29491746 details
PRKCZPTPN14BioGRID29491746 details
PRKCZTRIM21BioGRID29491746 details
PRKCZVCPBioGRID29491746 details
PRKCZMRPL46BioGRID29491746 details
PRKCZTUBB4ABioGRID29491746 details
PRKCZMRPL19BioGRID29491746 details
PRKCZSTK38BioGRID29491746 details
PRKCZGRWD1BioGRID29491746 details
PRKCZEEF1DBioGRID29491746 details
PRKCZMRPL18BioGRID29491746 details
PRKCZMRPL37BioGRID29491746 details
PRKCZEEF1B2BioGRID29491746 details
PRKCZPSMC4BioGRID29491746 details
PRKCZTUBA1CBioGRID29491746 details
PRKCZLGALS1BioGRID29491746 details
PRKCZMRPL39BioGRID29491746 details
PRKCZCOPB1BioGRID29491746 details
PRKCZCCT2BioGRID29491746 details
PRKCZSNRPD1BioGRID29491746 details
PRKCZKIF11BioGRID29491746 details
PRKCZDNAJC13BioGRID29491746 details
PRKCZMRPL50BioGRID29491746 details
PRKCZMRPL54BioGRID29491746 details
PRKCZMRPL52BioGRID29491746 details
PRKCZTAB1BioGRID29491746 details
PRKCZEIF5ABioGRID29491746 details
PRKCZFLNCBioGRID29491746 details
PRKCZKCTD2BioGRID29491746 details
PRKCZANXA2BioGRID29491746 details
PRKCZCLTCBioGRID29491746 details
PRKCZPSMD1BioGRID29491746 details
PRKCZMRPL55BioGRID29491746 details
PRKCZCAVIN1BioGRID29491746 details
PRKCZRNH1BioGRID29491746 details
PRKCZPSMC5BioGRID29491746 details
PRKCZPRDX1BioGRID29491746 details
PRKCZPPIL4BioGRID29491746 details
PRKCZFLNABioGRID29491746 details
PRKCZTPRBioGRID29491746 details
PRKCZMRPL38BioGRID29491746 details
PRKCZTUBA4ABioGRID29491746 details
PRKCZGAPDHBioGRID29491746 details
PRKCZGSNBioGRID29491746 details
PRKCZNSRP1BioGRID29491746 details
PRKCZMRPL48BioGRID29491746 details
PRKCZMYCBPBioGRID29491746 details
PRKCZEIF3BBioGRID29491746 details
PRKCZEIF3LBioGRID29491746 details
PRKCZHSPA9BioGRID29491746 details
PRKCZIMMTBioGRID29491746 details
PRKCZSNRPD2BioGRID29491746 details
PRKCZEEF1GBioGRID29491746 details
PRKCZCCT5BioGRID29491746 details
PRKCZEEF1A1BioGRID29491746 details
PRKCZEIF3HBioGRID29491746 details
PRKCZPPIABioGRID29491746 details
PRKCZDDX3XBioGRID29491746 details
PRKCZEIF4A1BioGRID29491746 details
PRKCZMRPL1BioGRID29491746 details
PRKCZKCTD17BioGRID29491746 details
PRKCZPRPSAP2BioGRID29491746 details
PRKCZCCT6ABioGRID29491746 details
PRKCZPLEKHA4BioGRID31091453 details
PRKCZPRKD1BioGRID31980649 details
PRKCZHSPA1ABioGRID, IntAct31980649 details
PRKCZHSPA1BIntAct31980649 details
PRKCZHNRNPLBioGRID28611215 details