Entity Details

Primary name TIMP3
Entity type gene
Source Source Link

Details

PrimaryID7078
RefseqGeneNG_009117
SymbolTIMP3
NameTIMP metallopeptidase inhibitor 3
Chromosome22
Location22q12.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1995-03-14
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsTIMP3_HUMAN

GO terms

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GOName
GO:0002020 protease binding
GO:0002576 platelet degranulation
GO:0004857 enzyme inhibitor activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0007601 visual perception
GO:0008191 metalloendopeptidase inhibitor activity
GO:0009725 response to hormone
GO:0010033 response to organic substance
GO:0010951 negative regulation of endopeptidase activity
GO:0031012 extracellular matrix
GO:0031089 platelet dense granule lumen
GO:0034097 response to cytokine
GO:0046872 metal ion binding
GO:0051045 negative regulation of membrane protein ectodomain proteolysis
GO:0062023 collagen-containing extracellular matrix
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway
GO:1904684 negative regulation of metalloendopeptidase activity

Diseases

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Interactions

36 interactions

InteractorPartnerSourcesPublicationsLink
TIMP3AGTR2BioGRID, IntAct18344519 details
TIMP3MMP2BioGRID, HPRD, IntAct10196161 28514442 7782289 details
TIMP3ADAM17BioGRID, HPRD12044879 details
TIMP3MMP3BioGRID, HPRD, IntAct11827795 26186194 28514442 details
TIMP3MMP13HPRD9065415 details
TIMP3MMP14HPRD8663332 details
TIMP3MMP9HPRD11827795 details
TIMP3KDRHPRD12652295 details
TIMP3ADAMTS5matrixdb22406378 details
TIMP3JUNMINT25609649 details
TIMP3KLRG2BioGRID, IntAct28514442 details
TIMP3VWCEBioGRID, IntAct28514442 details
TIMP3FAM136ABioGRID, IntAct28514442 details
TIMP3APPBioGRID, IntAct28514442 details
TIMP3DEFA1BioGRID, IntAct28514442 details
TIMP3DEFA1BIntAct28514442 details
TIMP3NELL1BioGRID, IntAct28514442 details
TIMP3CRPBioGRID, IntAct28514442 details
TIMP3DKK3BioGRID, IntAct28514442 details
TIMP3ADPGKBioGRID, IntAct28514442 details
TIMP3IFI30BioGRID, IntAct26186194 28514442 details
TIMP3IGFBP1BioGRID, IntAct28514442 details
TIMP3TIMP2BioGRID, IntAct26186194 28514442 details
TIMP3ASGR2BioGRID, IntAct26186194 28514442 details
TIMP3CSN1S1BioGRID, IntAct28514442 details
TIMP3COLEC11BioGRID, IntAct26186194 28514442 details
TIMP3COLEC10BioGRID, IntAct26186194 28514442 details
TIMP3VIMBioGRID, IntAct30021884 details
TIMP3ZUP1BioGRID29576527 details
TIMP3CA9BioGRID28692057 details
TIMP3PLEKHA4BioGRID31091453 details
TIMP3EZH2IntAct22094255 details
TIMP3SIRT1IntAct22094255 details
TIMP3DNMT1IntAct22094255 details
TIMP3H2AXIntAct22094255 details
TIMP3DNMT3BIntAct22094255 details