Entity Details

Primary name OTP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ5XKR4
EntryNameOTP_HUMAN
FullNameHomeobox protein orthopedia
TaxID9606
Evidenceevidence at protein level
Length325
SequenceStatuscomplete
DateCreated2007-06-26
DateModified2021-06-02

Ontological Relatives

GenesOTP

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001650 fibrillar center
GO:0002052 positive regulation of neuroblast proliferation
GO:0003677 DNA binding
GO:0005654 nucleoplasm
GO:0016604 nuclear body
GO:0021879 forebrain neuron differentiation
GO:0021979 hypothalamus cell differentiation
GO:0021985 neurohypophysis development
GO:0030182 neuron differentiation

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000047 Helix-turn-helix motifSiteConserved site
IPR001356 Homeobox domainDomainDomain
IPR003654 OAR domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR017970 Homeobox, conserved siteSiteConserved site

Diseases

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Interactions

8 interactions