Entity Details

Primary name SFRP4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ6FHJ7
EntryNameSFRP4_HUMAN
FullNameSecreted frizzled-related protein 4
TaxID9606
Evidenceevidence at protein level
Length346
SequenceStatuscomplete
DateCreated2005-03-15
DateModified2021-06-02

Ontological Relatives

GenesSFRP4

GO terms

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GOName
GO:0002092 positive regulation of receptor internalization
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0008285 negative regulation of cell population proliferation
GO:0009725 response to hormone
GO:0009986 cell surface
GO:0010628 positive regulation of gene expression
GO:0017147 Wnt-protein binding
GO:0030154 cell differentiation
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030510 regulation of BMP signaling pathway
GO:0043065 positive regulation of apoptotic process
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0045606 positive regulation of epidermal cell differentiation
GO:0055062 phosphate ion homeostasis
GO:0060070 canonical Wnt signaling pathway
GO:0060349 bone morphogenesis
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1902174 positive regulation of keratinocyte apoptotic process
GO:2000051 negative regulation of non-canonical Wnt signaling pathway
GO:2000119 negative regulation of sodium-dependent phosphate transport

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001134 Netrin domainDomainDomain
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-foldFamilyHomologous superfamily
IPR015526 Frizzled/secreted frizzled-related proteinFamilyFamily
IPR018933 Netrin module, non-TIMP typeDomainDomain
IPR020067 Frizzled domainDomainDomain
IPR026560 Secreted frizzled-related protein 4FamilyFamily
IPR036790 Frizzled cysteine-rich domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00606 CyclothiazideDrugbanksmall molecule
DB00790 PerindoprilDrugbanksmall molecule